Folding Pattern of a Succinyl and a Glutaric Glycine Derivative in Chloroform

1996 ◽  
Vol 61 (19) ◽  
pp. 6482-6483 ◽  
Author(s):  
Benjamin W. Gung ◽  
Zhaohai Zhu
Keyword(s):  
Folding Pattern ◽  
Glycine Derivative

Quasi-static Compressive Properties and Behavior of Single-cell Miura Origami Column Fabricated by 3D Printed PLA Material

2020 ◽  
Vol 3 (2) ◽  
pp. 66-73
Author(s):  
Farid Triawan ◽  
Geraldy Cahya Denatra ◽  
Djati Wibowo Djamari
Keyword(s):  
Single Cell ◽  
Peak Stress ◽  
Absorption Capacity ◽  
Compression Tests ◽  
Compressive Properties ◽  
Folding Pattern ◽  
Column Structure ◽  
Thin Walled ◽  
And Behavior ◽  
Initial Peak

The study of a thin-walled column structure has gained much attention due to its potential in many engineering applications, such as the crash box of a car. A thin-walled square column usually exhibits high initial peak force, which may become very dangerous to the driver or passenger. To address this issue, introducing some shape patterns, e.g., origami folding pattern, to the column may become a solution. The present work investigates the compressive properties and behavior of a square box column structure which adopts the Miura origami folding pattern. Several test pieces of single-cell Miura origami column with varying folding angle and layer height are fabricated by a 3D printer. The filament is made of Polylactic Acid (PLA), which is a brittle material. Then, compression tests are carried out to understand its compressive mechanical properties and behavior. The results show that introducing a Miura origami pattern to form a thin-walled square column can dramatically lower down the initial peak stress by 96.82% and, at the same time, increase its ductility, which eventually improves the energy absorption capacity by 61.68% despite the brittle fracture behavior.

scholarly journals IN SILICO STUDIES ON FUNCTIONALIZED AZAGLYCINE DERIVATIVES CONTAINING 2, 4-THIAZOLIDINEDIONE SCAFFOLD ON MULTIPLE TARGETS

2017 ◽  
Vol 9 (8) ◽  
pp. 209 ◽  
Author(s):  
Arifa Begum ◽  
Shaheen Begum ◽  
Prasad Kvsrg ◽  
Bharathi K.
Keyword(s):  
Molecular Docking ◽  
Oral Bioavailability ◽  
In Silico ◽  
Viral Infections ◽  
Target Prediction ◽  
Docking Studies ◽  
Antidiabetic Activity ◽  
Molecular Docking Studies ◽  
In Silico Studies ◽  
Glycine Derivative

Objective: The 2, 4-thiazolidinedione containing compounds could lead to most promising scaffolds with higher efficiency toward the targets recognized for its antidiabetic activity when combined with azaglycine moiety. The objective of the present work was to merge functionalized aza glycines with 2, 4-thiazolidinediones, perform in silico evaluation by molecular properties prediction and undertake the molecular docking studies with targets relevant to diabetes, bacterial and viral infections using Swiss Dock programme for unraveling the target identification which can be used for further designing.Methods: (i) In silico studies were performed using Molinspiration online tool, Swiss ADME website and Swiss Target Prediction websites to compute the physicochemical descriptors, oral bioavailability and brain penetration. (ii) Molecular docking studies were performed using Swiss Dock web service for enumeration of binding affinities and assess their biological potentiality.Results: The results predicted good drug likeness, solubility, permeability and oral bioavailability for the compounds. All the compounds showed good docking scores as compared to the reference drugs. The N-oleoyl functionalized aza glycine derivative demonstrated superior binding properties towards all the studied target reference proteins, suggesting its significance in pharmacological actions.Conclusion: The binding interactions observed in the molecular docking studies suggest good binding affinity of the oleoyl functionalized aza glycine derivative, indicating that this derivative would be a promising lead for further investigations of anti-viral, anti-inflammatory and anti-diabetic activities.

Mixed Helices—A General Folding Pattern in Homologous Peptides?

2004 ◽  
Vol 43 (12) ◽  
pp. 1594-1597 ◽  
Author(s):  
Carsten Baldauf ◽  
Robert Günther ◽  
Hans-Jörg Hofmann
Keyword(s):  
Folding Pattern
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