Magnesium Methyl Carbonate-Activated Alkylation of Methyl Ketones with an ω-Halo Nitrile, Esters, and Amides

1997 ◽  
Vol 62 (5) ◽  
pp. 1348-1355 ◽  
Author(s):  
Elli S. Hand ◽  
Stephen C. Johnson ◽  
David C. Baker
Keyword(s):  
Methyl Ketones ◽  
Methyl Carbonate

Acetyl Nitrate Mediated Conversion of Methyl Ketones to Diverse Carboxylic Acid Derivatives

2021 ◽  
Author(s):  
Joseph N. Capilato ◽  
Peter J Pellegrinelli ◽  
Josephine Bernard ◽  
Logan Schnorbus ◽  
Shane Philippi ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Methyl Ketones ◽  
Oxidative Conversion ◽  
Haloform Reaction ◽  
Acetyl Nitrate

The development of a novel acetyl nitrate mediated oxidative conversion of methyl ketones to carboxylic acid derivatives is described. By analogy to the haloform reaction and supported by experimental and...

Selective Synthesis of Ethyl Methyl Carbonate via Catalytic Reactive Distillation over Heterogeneous MgO/HZSM‐5

2019 ◽  
Vol 4 (24) ◽  
pp. 7366-7370
Author(s):  
Jianhua Lv ◽  
Huanhuan Cai ◽  
Yong Guo ◽  
Wenrui Liu ◽  
Ning Tao ◽  
...  
Keyword(s):  
Reactive Distillation ◽  
Selective Synthesis ◽  
Ethyl Methyl ◽  
Ethyl Methyl Carbonate ◽  
Methyl Carbonate

Facile Approach to Geminal Heterodihalogenation. One-Pot Synthesis of α-Bromo-α-Chloro Ketones

Synlett ◽  
2020 ◽  
Vol 31 (14) ◽  
pp. 1430-1434
Author(s):  
Ming Bian ◽  
Jin-feng Zhou ◽  
Dong-min Tang
Keyword(s):  
Drug Discovery ◽  
Dimethyl Sulfoxide ◽  
Functional Groups ◽  
Methyl Ketones ◽  
One Pot ◽  
One Pot Synthesis ◽  
Operational Simplicity

An efficient and practical protocol for the geminal heterodihalogenation of methyl ketones by using readily available dimethyl sulfoxide and a combination of HCl and HBr is reported. Control experiments suggested that the acidity of the solution, as well as the oxidizing ability and nucleophilicity of the dimethyl sulfoxide might work cooperatively in ensuring the success of the tandem substitution. Its operational simplicity, easy accessibility, and mild oxidative conditions suggest that the present strategy might be useful for the assembly of bromochloromethyl functional groups in drug discovery.

scholarly journals Innentitelbild: Chemoselective Oxidative C(CO)C(methyl) Bond Cleavage of Methyl Ketones to Aldehydes Catalyzed by CuI with Molecular Oxygen (Angew. Chem. 43/2013)

2013 ◽  
Vol 125 (43) ◽  
pp. 11384-11384
Author(s):  
Lin Zhang ◽  
Xihe Bi ◽  
Xiaoxue Guan ◽  
Xingqi Li ◽  
Qun Liu ◽  
...  
Keyword(s):  
Molecular Oxygen ◽  
Bond Cleavage ◽  
Methyl Ketones
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