scholarly journals Reductions, Reductive Alkylations, and Intramolecular Cyclizations of Acyl Silanes with Samarium Diiodide or Tributyltin Hydride

1996 ◽  
Vol 61 (5) ◽  
pp. 1794-1805 ◽  
Author(s):  
Tsung-Hsun Chuang ◽  
Jim-Min Fang ◽  
Weir-Torn Jiaang ◽  
Yeun-Min Tsai
Keyword(s):  
Samarium Diiodide ◽  
Tributyltin Hydride ◽  
Intramolecular Cyclizations

Desulfonylation of Amides using Tributyltin Hydride, Samarium Diiodide or Zinc/Titanium Tetrachloride. A Comparison of Methods

Tetrahedron ◽  
2000 ◽  
Vol 56 (7) ◽  
pp. 979-988 ◽  
Author(s):  
Haydn S Knowles ◽  
Andrew F Parsons ◽  
Robert M Pettifer ◽  
Stéphane Rickling
Keyword(s):  
Titanium Tetrachloride ◽  
Samarium Diiodide ◽  
Comparison Of Methods ◽  
Tributyltin Hydride

scholarly journals Synthesis of Aminocyclitols by Intramolecular Reductive Coupling of Carbohydrate Derived δ- and ε-Functionalized Oxime Ethers Promoted by Tributyltin Hydride or Samarium Diiodide†

1997 ◽  
Vol 62 (21) ◽  
pp. 7397-7412 ◽  
Author(s):  
José Marco-Contelles ◽  
Pilar Gallego ◽  
Mercedes Rodríguez-Fernández ◽  
Noureddine Khiar ◽  
Christine Destabel ◽  
...  
Keyword(s):  
Samarium Diiodide ◽  
Reductive Coupling ◽  
Tributyltin Hydride

scholarly journals Synthesis and Antiproliferative Evaluation of 2-Deoxy-N-glycosylbenzotriazoles/imidazoles

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3742
Author(s):  
Caleigh S. Garton ◽  
Noelle K. DeRose ◽  
Dylan Dominguez ◽  
Maria L. Turbi-Henderson ◽  
Ashley L. Lehr ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Addition Reaction ◽  
Protecting Group ◽  
Human Breast ◽  
Lung Cancer Cell ◽  
Subsequent Removal ◽  
Anticancer Properties ◽  
Tributyltin Hydride ◽  
High Yields

A series of 2-deoxy-2-iodo-α-d-mannopyranosylbenzotriazoles was synthesized using the benzyl, 4,6-benzylidene and acetyl protected D-glucal in the presence of N-iodosuccinimide (NIS). Subsequent removal of the iodine at the C-2 position using tributyltin hydride under free radical conditions afforded the 2-deoxy-α-d-glucopyranosylbenzotriazoles in moderate to high yields. This method was extended to the preparation of substituted 2-deoxy-β-d-glucopyranosylimidazoles as well. The stereoselectivity of the addition reaction and the effect of the protecting group and temperature on anomer distribution of the benzotriazole series were also investigated. The anticancer properties of the newly synthesized compounds were evaluated in a series of viability studies using HeLa (human cervical adenocarcinoma), human breast and lung cancer cell lines. The N-[3,4,6-tri-O-benzyl-2-deoxy-α-d-glucopyranosyl]-1H-benzotriazole and the N-[3,4,6-tri-O-acetyl-2-deoxy-α-d-glucopyranosyl]-2H-benzotriazole were found to be the most potent cancer cell inhibitors at 20 µM concentrations across all four cell lines.

Intramolecular cyclizations leading to bridgehead bicyclics2. 5,5-dialkylhydantoin derivatives

1977 ◽  
Vol 14 (3) ◽  
pp. 511-513 ◽  
Author(s):  
Katsuhide Okada ◽  
James A. Kelley ◽  
John. S. Driscoll
Keyword(s):  
Intramolecular Cyclizations
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