Organocatalytic Asymmetric Friedel−Crafts Alkylation/Cyclization Cascade Reaction of 1-Naphthols and α,β-Unsaturated Aldehydes: An Enantioselective Synthesis of Chromanes and Dihydrobenzopyranes

2009 ◽  
Vol 74 (17) ◽  
pp. 6881-6884 ◽  
Author(s):  
Liang Hong ◽  
Lei Wang ◽  
Wangsheng Sun ◽  
Kwokyin Wong ◽  
Rui Wang
Keyword(s):  
Cascade Reaction ◽  
Enantioselective Synthesis ◽  
Unsaturated Aldehydes

Assembly of Fluorinated Chromanones via Enantioselective Tandem Reaction

2021 ◽  
Author(s):  
Mengxue Lu ◽  
Zongli Xiong ◽  
Yuqiao Zhou ◽  
Xin Wang ◽  
Xiaoyi Li ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Tandem Reaction ◽  
Unsaturated Aldehydes ◽  
Stereogenic Centers ◽  
First Time

The enantioselective synthesis of fluorinated tricyclic chromanones with multiple vicinal stereogenic centers has been realized for the first time, through the tandem reaction between 2-fluorinated 1-(2-hydroxyaryl)-1,3-diketones and α,β-unsaturated aldehydes. In...

Asymmetric Organocatalytic Michael Addition–Cyclization Cascade of Cyclopentane-1,2-dione with Substituted α,β-Unsaturated Aldehydes

Synthesis ◽  
2017 ◽  
Vol 49 (14) ◽  
pp. 3118-3125 ◽  
Author(s):  
Margus Lopp ◽  
Gert Preegel ◽  
Estelle Silm ◽  
Sandra Kaabel ◽  
Ivar Järving ◽  
...  
Keyword(s):  
Michael Addition ◽  
Cascade Reaction ◽  
One Pot ◽  
Unsaturated Aldehydes ◽  
Michael Acceptors

An asymmetric organocatalytic Michael addition–cyclization cascade reaction has been developed using cyclopentane-1,2-dione as a Michael donor and α,β-unsaturated aldehydes as Michael acceptors. Bicyclic hemiacetals were obtained in excellent yields and enantioselectivities. On the basis of the results, a one-pot reaction has been developed to obtain chiral 3-substituted cyclopentane-1,2-diones and substituted dihydropyrans in good yields and excellent enantioselectivity.

Cascade bio-hydroxylation and dehalogenation for one-pot enantioselective synthesis of optically active β-halohydrins from halohydrocarbons

2019 ◽  
Vol 21 (16) ◽  
pp. 4324-4328 ◽  
Author(s):  
Hai-Bo Cui ◽  
Ling-Zhi Xie ◽  
Nan-Wei Wan ◽  
Qing He ◽  
Zhi Li ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Optically Active ◽  
Enantioselective Synthesis ◽  
One Pot

A stereoselective hydroxylation and enantioselective dehalogenation cascade reaction was developed for the synthesis of optically active β-haloalcohols from halohydrocarbons.

One-pot asymmetric synthesis of a hexahydrophenanthridine scaffold containing five stereocenters via an organocatalytic quadruple-cascade reaction

2021 ◽  
Author(s):  
Xiao-Long Zhang ◽  
Kai-Xiang Feng ◽  
Jian-Liang Hu ◽  
Qiao-Yu Shen ◽  
Wang-Sheng Huang ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Cascade Reaction ◽  
One Pot ◽  
Unsaturated Aldehydes ◽  
Aldol Cyclization

An organocatalytic enantioselective aza-Michael-Michael-Michael/aldol cyclization quadruple-cascade reaction of 2-amino-β-nitrostyrenes and α,β-unsaturated aldehydes has been developed for the construction of fully substituted hexahydrophenanthridine.

Enantioselective Synthesis of Trifluoromethyl-Substituted 2-Isoxazolines: Asymmetric Hydroxylamine/Enone Cascade Reaction

2010 ◽  
Vol 49 (33) ◽  
pp. 5762-5766 ◽  
Author(s):  
Kazutaka Matoba ◽  
Hiroyuki Kawai ◽  
Tatsuya Furukawa ◽  
Akihiro Kusuda ◽  
Etsuko Tokunaga ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Enantioselective Synthesis
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