Lewis Acid Promoted Carbon−Carbon Double-Bond Formation via Organozinc Reagents and Carbonyl Compounds

2009 ◽  
Vol 74 (17) ◽  
pp. 6855-6858 ◽  
Author(s):  
Zhi-Yong Peng ◽  
Fang-Fang Ma ◽  
Lv-Feng Zhu ◽  
Xiao-Min Xie ◽  
Zhaoguo Zhang
Keyword(s):  
Double Bond ◽  
Lewis Acid ◽  
Carbonyl Compounds ◽  
Bond Formation ◽  
Carbon Double Bond ◽  
Organozinc Reagents

ChemInform Abstract: Lewis Acid Promoted Carbon—Carbon Double-Bond Formation via Organozinc Reagents and Carbonyl Compounds.

ChemInform ◽  
2010 ◽  
Vol 41 (3) ◽  
Author(s):  
Zhi-Yong Peng ◽  
Fang-Fang Ma ◽  
Lv-Feng Zhu ◽  
Xiao-Min Xie ◽  
Zhaoguo Zhang
Keyword(s):  
Double Bond ◽  
Lewis Acid ◽  
Carbonyl Compounds ◽  
Bond Formation ◽  
Carbon Double Bond ◽  
Organozinc Reagents

Neodymium-Promoted Highly Selective Carbon–Carbon Double Bond Formation of Ketones with Allyl Halides in the Presence of Diethyl Phosphite

Synthesis ◽  
2020 ◽  
Vol 52 (22) ◽  
pp. 3446-3451
Author(s):  
Songlin Zhang ◽  
Dengbing Xie ◽  
Yiqiong Wang ◽  
Bo Yang
Keyword(s):  
Double Bond ◽  
Bond Formation ◽  
Point Of View ◽  
Diethyl Phosphite ◽  
Reaction Conditions ◽  
One Pot ◽  
Mild Conditions ◽  
Carbon Double Bond ◽  
Allyl Halides ◽  
First Time

The carbon–carbon double bond formation via neodymium-mediated Barbier-type reaction of ketones and allyl halides in the presence of diethyl phosphite is reported for the first time. The reaction is highly α-regioselective and was conveniently carried out under mild conditions in a one-pot fashion. From a synthetic point of view, a series of conjugated alkenes were obtained in moderate to good yields in this one-pot reaction with feasible reaction conditions.

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