Concerning the Hydrolytic Stability of 8-Aryl-2′-deoxyguanosine Nucleoside Adducts: Implications for Abasic Site Formation at Physiological pH

2009 ◽  
Vol 74 (16) ◽  
pp. 5793-5802 ◽  
Author(s):  
Katherine M. Schlitt ◽  
Ke-wen M. Sun ◽  
Robert J. Paugh ◽  
Andrea L. Millen ◽  
Lex Navarro-Whyte ◽  
...  
Keyword(s):  
Hydrolytic Stability ◽  
Site Formation ◽  
Abasic Site ◽  
Nucleoside Adducts

Influence of Chlorine Substitution on the Hydrolytic Stability of Biaryl Ether Nucleoside Adducts Produced by Phenolic Toxins

2013 ◽  
Vol 78 (14) ◽  
pp. 7176-7185 ◽  
Author(s):  
Michael S. Kuska ◽  
Mohadeseh Majdi Yazdi ◽  
Aaron A. Witham ◽  
Heidi A. Dahlmann ◽  
Shana J. Sturla ◽  
...  
Keyword(s):  
Hydrolytic Stability ◽  
Chlorine Substitution ◽  
Biaryl Ether ◽  
Nucleoside Adducts

ChemInform Abstract: Derivatization of Oligonucleotides Through Abasic Site Formation

ChemInform ◽  
2010 ◽  
Vol 22 (43) ◽  
pp. no-no
Author(s):  
J. J. VASSEUR ◽  
D. PEOC'H ◽  
B. RAYNER ◽  
J. L. IMBACH
Keyword(s):  
Site Formation ◽  
Abasic Site

scholarly journals Histone tails decrease N7-methyl-2′-deoxyguanosine depurination and yield DNA–protein cross-links in nucleosome core particles and cells

2018 ◽  
Vol 115 (48) ◽  
pp. E11212-E11220 ◽  
Author(s):  
Kun Yang ◽  
Daeyoon Park ◽  
Natalia Y. Tretyakova ◽  
Marc M. Greenberg
Keyword(s):  
Alkylating Agents ◽  
Histone Variants ◽  
Site Formation ◽  
Abasic Site ◽  
Histone Tails ◽  
Nucleosome Core ◽  
Nucleosome Core Particles ◽  
Cross Links ◽  
Positively Charged ◽  
Core Particles

Monofunctional alkylating agents preferentially react at the N7 position of 2′-deoxyguanosine in duplex DNA. Methylated DNA, such as that produced by methyl methanesulfonate (MMS) and temozolomide, exists for days in organisms. The predominant consequence of N7-methyl-2′-deoxyguanosine (MdG) is widely believed to be abasic site (AP) formation via hydrolysis, a process that is slow in free DNA. Examination of MdG reactivity within nucleosome core particles (NCPs) provided two general observations. MdG depurination rate constants are reduced in NCPs compared with when the identical DNA sequence is free in solution. The magnitude of the decrease correlates with proximity to the positively charged histone tails, and experiments in NCPs containing histone variants reveal that positively charged amino acids are responsible for the decreased rate of abasic site formation from MdG. In addition, the lysine-rich histone tails form DNA–protein cross-links (DPCs) with MdG. Cross-link formation is reversible and is ascribed to nucleophilic attack at the C8 position of MdG. DPC and retarded abasic site formation are observed in NCPs randomly damaged by MMS, indicating that these are general processes. Histone–MdG cross-links were also detected by mass spectrometry in chromatin isolated from V79 Chinese hamster lung cells treated with MMS. The formation of DPCs following damage by a monofunctional alkylating agent has not been reported previously. These observations reveal the possibility that such DPCs may contribute to the cytotoxicity of monofunctional alkylating agents, such as MMS, N-methyl-N-nitrosourea, and temozolomide.

scholarly journals Kinetics of DNA Adducts and Abasic Site Formation in Tissues of Mice Treated with a Nitrogen Mustard

2020 ◽  
Vol 33 (4) ◽  
pp. 988-998
Author(s):  
Haoqing Chen ◽  
Ziyou Cui ◽  
Leila Hejazi ◽  
Lihua Yao ◽  
Scott J. Walmsley ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Nitrogen Mustard ◽  
Site Formation ◽  
Abasic Site ◽  
Kinetics Of

scholarly journals HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation

Cell Reports ◽  
2020 ◽  
Vol 31 (9) ◽  
pp. 107705 ◽  
Author(s):  
Kavi P.M. Mehta ◽  
Courtney A. Lovejoy ◽  
Runxiang Zhao ◽  
Darren R. Heintzman ◽  
David Cortez
Keyword(s):  
Replication Fork ◽  
Double Strand Breaks ◽  
Site Formation ◽  
Abasic Site ◽  
Strand Breaks ◽  
Replication Fork Progression

Quantitative One Step Derivatization of Oligonucleotides by a Fluorescent Label Through Abasic Site Formation

1997 ◽  
Vol 16 (10-11) ◽  
pp. 2069-2077 ◽  
Author(s):  
Didier Boturyn ◽  
Eric Defrancq ◽  
Veacute; onique Ducros ◽  
Catherine Fontaine ◽  
Jean Lhomme
Keyword(s):  
Fluorescent Label ◽  
Site Formation ◽  
Abasic Site ◽  
One Step

Derivatization of Oligonucleotides Through Abasic Site Formation

1991 ◽  
Vol 10 (1-3) ◽  
pp. 107-117 ◽  
Author(s):  
J.-J. Vasseur ◽  
D. Peoc'h ◽  
B. Rayner ◽  
J.-L. Imbach
Keyword(s):  
Site Formation ◽  
Abasic Site

ChemInform Abstract: Quantitative One Step Derivatization of Oligonucleotides by a Fluorescent Label Through Abasic Site Formation.

ChemInform ◽  
2010 ◽  
Vol 29 (15) ◽  
pp. no-no
Author(s):  
D. BOTURYN ◽  
E. DEFRANCQ ◽  
V. DUCROS ◽  
C. FONTAINE ◽  
J. LHOMME
Keyword(s):  
Fluorescent Label ◽  
Site Formation ◽  
Abasic Site ◽  
One Step
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