Synthesis of Annulated 2H-Indazoles and 1,2,3- and 1,2,4-Triazoles via a One-Pot Palladium-Catalyzed Alkylation/Direct Arylation Reaction

2008 ◽  
Vol 73 (22) ◽  
pp. 9164-9167 ◽  
Author(s):  
Benoît Laleu ◽  
Mark Lautens
Keyword(s):  
One Pot ◽  
Direct Arylation ◽  
Palladium Catalyzed

scholarly journals Room temperature Palladium-Catalyzed C─H Functionalization of Benzothiazole with Iodo(Hetero)Arenes

2020 ◽  
Author(s):  
Yuvraj Bhujbal ◽  
kamlesh vadagaonkar ◽  
santosh kori ◽  
Anant Kapdi
Keyword(s):  
Room Temperature ◽  
Antitumor Agent ◽  
One Pot ◽  
Direct Arylation ◽  
Palladium Catalyzed

A versatile synthetic protocol involving the room temperature direct arylation of benzothiazole with a wide variety of iodo(hetero)arenes under palladium-catalyzed conditions and promoted by HFIP as the reaction solvent has been presented herewith. An in-situ one-pot sequential HFIP promoted selective iodination of (hetero)arenes followed by Pd-catalyzed direct arylation of benzothiazole has also been disclosed. Synthesis of PMX 610 (antitumor agent) analog has been disclosed and also CJM 126 (antitumor agent) has been synthesized.

scholarly journals Room temperature Palladium-Catalyzed C─H Functionalization of Benzothiazole with Iodo(Hetero)Arenes

2020 ◽  
Author(s):  
Yuvraj Bhujbal ◽  
kamlesh vadagaonkar ◽  
santosh kori ◽  
Anant Kapdi
Keyword(s):  
Room Temperature ◽  
Antitumor Agent ◽  
One Pot ◽  
Direct Arylation ◽  
Palladium Catalyzed

A versatile synthetic protocol involving the room temperature direct arylation of benzothiazole with a wide variety of iodo(hetero)arenes under palladium-catalyzed conditions and promoted by HFIP as the reaction solvent has been presented herewith. An in-situ one-pot sequential HFIP promoted selective iodination of (hetero)arenes followed by Pd-catalyzed direct arylation of benzothiazole has also been disclosed. Synthesis of PMX 610 (antitumor agent) analog has been disclosed and also CJM 126 (antitumor agent) has been synthesized.

Preparation of Annulated Nitrogen-Containing Heterocycles via a One-Pot Palladium-Catalyzed Alkylation/Direct Arylation Sequence

2006 ◽  
Vol 8 (10) ◽  
pp. 2043-2045 ◽  
Author(s):  
Christophe Blaszykowski ◽  
Evangelos Aktoudianakis ◽  
Cyril Bressy ◽  
Dino Alberico ◽  
Mark Lautens
Keyword(s):  
One Pot ◽  
Direct Arylation ◽  
Palladium Catalyzed

scholarly journals Preparation of Annulated Nitrogen-Containing Heterocycles via a One-Pot Palladium-Catalyzed Alkylation/Direct Arylation Sequence.

ChemInform ◽  
2006 ◽  
Vol 37 (37) ◽  
Author(s):  
Christophe Blaszykowski ◽  
Evangelos Aktoudianakis ◽  
Cyril Bressy ◽  
Dino Alberico ◽  
Mark Lautens
Keyword(s):  
One Pot ◽  
Direct Arylation ◽  
Palladium Catalyzed

Improved Synthesis of Symmetrical 2,5-Diarylimidazoles by One-Pot Palladium-Catalyzed Direct Arylation Tailored on the Electronic Features of the Aryl Halide

Synthesis ◽  
2017 ◽  
Vol 49 (20) ◽  
pp. 4676-4686 ◽  
Author(s):  
Marco Lessi ◽  
Gianmarco Panzetta ◽  
Giulia Marianetti ◽  
Fabio Bellina
Keyword(s):  
Aryl Halide ◽  
One Pot ◽  
Direct Arylation ◽  
One Pot Synthesis ◽  
Aryl Bromides ◽  
Palladium Catalyzed ◽  
The One

Two methods for the one-pot synthesis of 2,5-diarylimidazoles by palladium-catalyzed direct C–H arylation of 1-substituted imidazoles with aryl bromides have been devised. The first method, promoted by copper(I) iodide, is best suited for electron-poor aryl bromides, and also allows the 2,5-diarylation of thiazole and oxazole. The use of xylene instead of DMA is the key for the efficiency of the second method, which gives the best results with electron-rich aryl bromides.

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