Recent Advances in Asymmetric Catalytic Methods for the Formation of Acyclic α,α-Disubstituted α-Amino Acids

2014 ◽  
Vol 80 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Alison E. Metz ◽  
Marisa C. Kozlowski
Keyword(s):  
Amino Acids ◽  
Asymmetric Catalytic ◽  
Recent Advances

scholarly journals Recent Advances in Rapid Synthesis of Non-proteinogenic Amino Acids from Proteinogenic Amino Acids Derivatives via Direct Photo-Mediated C–H Functionalization

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5270
Author(s):  
Zhenbo Yuan ◽  
Xuanzhong Liu ◽  
Changmei Liu ◽  
Yan Zhang ◽  
Yijian Rao
Keyword(s):  
Amino Acids ◽  
Direct Synthesis ◽  
Environmentally Friendly ◽  
Powerful Method ◽  
Rapid Synthesis ◽  
Conservation Of Energy ◽  
Mild Conditions ◽  
Recent Advances ◽  
Recent Developments

Non-proteinogenic amino acids have attracted tremendous interest for their essential applications in the realm of biology and chemistry. Recently, rising C–H functionalization has been considered an alternative powerful method for the direct synthesis of non-proteinogenic amino acids. Meanwhile, photochemistry has become popular for its predominant advantages of mild conditions and conservation of energy. Therefore, C–H functionalization and photochemistry have been merged to synthesize diverse non-proteinogenic amino acids in a mild and environmentally friendly way. In this review, the recent developments in the photo-mediated C–H functionalization of proteinogenic amino acids derivatives for the rapid synthesis of versatile non-proteinogenic amino acids are presented. Moreover, postulated mechanisms are also described wherever needed.

Recent Advances in the Pharmacology of Excitatory Amino Acids in the Mammalian Central Nervous System

Excitotoxins ◽  
1983 ◽  
pp. 43-54 ◽  
Author(s):  
J. Davies ◽  
R. H. Evans ◽  
A. W. Jones ◽  
K. N. Mewett ◽  
D. A. S. Smith ◽  
...  
Keyword(s):  
Amino Acids ◽  
Central Nervous System ◽  
Nervous System ◽  
Excitatory Amino Acids ◽  
Mammalian Central Nervous System ◽  
Recent Advances

scholarly journals Catalytic asymmetric cycloaddition reactions of enoldiazo compounds

2019 ◽  
Vol 17 (17) ◽  
pp. 4183-4195 ◽  
Author(s):  
Kostiantyn O. Marichev ◽  
Michael P. Doyle
Keyword(s):  
Cycloaddition Reactions ◽  
Asymmetric Catalytic ◽  
Recent Advances ◽  
Catalytic Asymmetric

Review of recent advances in asymmetric catalytic cycloaddition reactions of silyl-protected enoldiazo compounds.

scholarly journals Recent Advances in Affinity MOF-Based Sorbents with Sample Preparation Purposes

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4216
Author(s):  
Héctor Martínez Pérez-Cejuela ◽  
José Manuel Herrero-Martínez ◽  
Ernesto F. Simó-Alfonso
Keyword(s):  
Amino Acids ◽  
Sample Preparation ◽  
Metal Organic Frameworks ◽  
Selective Extraction ◽  
Real Samples ◽  
Recent Advances ◽  
Different Types ◽  
Metal Organic

This review summarizes the recent advances concerning metal–organic frameworks (MOFs) modified with several biomolecules (e.g., amino acids, nucleobases, proteins, antibodies, aptamers, etc.) as ligands to prepare affinity-based sorbents for application in the sample preparation field. The preparation and incorporation strategies of these MOF-based affinity materials were described. Additionally, the different types of ligands that can be employed for the synthesis of these biocomposites and their application as sorbents for the selective extraction of molecules and clean-up of complex real samples is reported. The most important features of the developed biocomposites will be discussed throughout the text in different sections, and several examples will be also commented on in detail.

scholarly journals Asymmetric catalytic construction of fully substituted carbon stereocenters using acyclic α-branched β-ketocarbonyls: the “Methyl Rule” widely exists

2020 ◽  
Vol 7 (21) ◽  
pp. 3557-3577
Author(s):  
Deqian Sun ◽  
Shuang Yang ◽  
Xinqiang Fang
Keyword(s):  
General Principle ◽  
Asymmetric Catalytic ◽  
Recent Advances ◽  
Catalytic Asymmetric

This review illustrates the recent advances in catalytic asymmetric α-functionalization of acyclic β-ketocarbonyls. A thorough survey of all these reactions indicates the existance of a general principle which is called the “Methyl Rule”.

Recent Advances in Photoredox Catalysis Enabled Functionalization of α-Amino Acids and Peptides: Concepts, Strategies and Mechanisms

Synthesis ◽  
2019 ◽  
Vol 51 (14) ◽  
pp. 2759-2791 ◽  
Author(s):  
Jian-Quan Liu ◽  
Andrey Shatskiy ◽  
Bryan S. Matsuura ◽  
Markus D. Kärkäs
Keyword(s):  
Amino Acids ◽  
Visible Light ◽  
Hypervalent Iodine ◽  
Amino Acid Residues ◽  
Photoredox Catalysis ◽  
Metal Catalysis ◽  
Specific Amino Acid ◽  
Recent Advances ◽  
Redox Active ◽  
Decarboxylative Coupling

The selective modification of α-amino acids and peptides constitutes a pivotal arena for accessing new peptide-based materials and therapeutics. In recent years, visible light photoredox catalysis has appeared as a powerful platform for the activation of small molecules via single-electron transfer events, allowing previously inaccessible reaction pathways to be explored. This review outlines the recent advances, mechanistic underpinnings, and opportunities of applying photoredox catalysis to the expansion of the synthetic repertoire for the modification of specific amino acid residues.1 Introduction2 Visible-Light-Mediated Functionalization of α-Amino Acids2.1 Decarboxylative Functionalization Involving Redox-Active Esters2.2 Direct Decarboxylative Coupling Strategies2.3 Hypervalent Iodine Reagents2.4 Dual Photoredox and Transition-Metal Catalysis2.5 Amination and Deamination Strategies3 Photoinduced Peptide Diversification3.1 Gese-Type Bioconjugation Methods3.2 Peptide Macrocyclization through Photoredox Catalysis3.3 Biomolecule Conjugation through Arylation3.4 C–H Functionalization Manifolds4 Conclusions and Outlook

Recent Advances in Stereoselective Synthesis and Application of β-Amino Acids

2009 ◽  
Vol 41 (6) ◽  
pp. 429-478 ◽  
Author(s):  
Brad E. Sleebs ◽  
T. T. Van Nguyen ◽  
Andrew B. Hughes
Keyword(s):  
Amino Acids ◽  
Stereoselective Synthesis ◽  
Recent Advances
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