Design, Synthesis, and Conformational Analysis of Trispyrimidonamides as α-Helix Mimetics

2014 ◽  
Vol 79 (4) ◽  
pp. 1582-1593 ◽  
Author(s):  
Lukas Spanier ◽  
Emanuele Ciglia ◽  
Finn K. Hansen ◽  
Krystina Kuna ◽  
Walter Frank ◽  
...  
Keyword(s):  
Conformational Analysis ◽  
Design Synthesis ◽  
Helix Mimetics ◽  
Α Helix

scholarly journals Design, Synthesis, and Conformational Analysis of Oligobenzanilides as Multifacial α-Helix Mimetics

2019 ◽  
Vol 21 (12) ◽  
pp. 4433-4438 ◽  
Author(s):  
Theo Flack ◽  
Charles Romain ◽  
Andrew J. P. White ◽  
Peter R. Haycock ◽  
Anna Barnard
Keyword(s):  
Conformational Analysis ◽  
Design Synthesis ◽  
Helix Mimetics ◽  
Α Helix

Design, synthesis, and conformational analysis of 3-cyclo-butylcarbamoyl hydantoins as novel hydrogen bond driven universal peptidomimetics

2018 ◽  
Vol 16 (4) ◽  
pp. 521-525 ◽  
Author(s):  
M. C. Bellucci ◽  
M. Frigerio ◽  
C. Castellano ◽  
F. Meneghetti ◽  
A. Sacchetti ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Molecular Modeling ◽  
Conformational Analysis ◽  
Secondary Structures ◽  
Nmr Studies ◽  
Design Synthesis ◽  
X Ray ◽  
Α Helix

3-cyclo-Butylcarbamoyl hydantoins are able to mimic α-helix and β-turn secondary structures as assessed by molecular modeling, NMR studies, and X-ray analysis.

Synthesis of Pyridazine-Based Scaffolds as α-Helix Mimetics

2007 ◽  
Vol 9 (19) ◽  
pp. 3733-3736 ◽  
Author(s):  
Alessandro Volonterio ◽  
Lionel Moisan ◽  
Julius Rebek
Keyword(s):  
Helix Mimetics ◽  
Α Helix

Expedient route to functionalized and water soluble 5-6-5 imidazole-phenyl-thiazole based α-helix mimetics

Tetrahedron ◽  
2013 ◽  
Vol 69 (5) ◽  
pp. 1663-1668 ◽  
Author(s):  
Christopher G. Cummings ◽  
Andrew D. Hamilton
Keyword(s):  
Water Soluble ◽  
Helix Mimetics ◽  
Α Helix

Synthesis of α-helix mimetics with four side-chains

2008 ◽  
Vol 18 (22) ◽  
pp. 5909-5911 ◽  
Author(s):  
Per Restorp ◽  
Julius Rebek
Keyword(s):  
Side Chains ◽  
Helix Mimetics ◽  
Α Helix

scholarly journals Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

2009 ◽  
Vol 49 (4) ◽  
pp. 736-739 ◽  
Author(s):  
Ishu Saraogi ◽  
James A. Hebda ◽  
Jorge Becerril ◽  
Lara A. Estroff ◽  
Andrew D. Miranker ◽  
...  
Keyword(s):  
Islet Amyloid Polypeptide ◽  
Islet Amyloid ◽  
Helix Mimetics ◽  
Α Helix

scholarly journals Towards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold

2015 ◽  
Vol 13 (32) ◽  
pp. 8642-8646 ◽  
Author(s):  
M. E. Lanning ◽  
P. T. Wilder ◽  
H. Bailey ◽  
B. Drennen ◽  
M. Cavalier ◽  
...  
Keyword(s):  
Helix Mimetics ◽  
Α Helix ◽  
Key Residues

Key residues on opposing faces of the Bak-BH3 α-helix were recapitulated by the 2,6,9-tri-substitution of a purine scaffold.

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