Chemoenzymatic Synthesis of Hydrophobic Glycoprotein: Synthesis of Saposin C Carrying Complex-Type Carbohydrate

2012 ◽  
Vol 77 (21) ◽  
pp. 9437-9446 ◽  
Author(s):  
Hironobu Hojo ◽  
Hiromasa Tanaka ◽  
Masashi Hagiwara ◽  
Yuya Asahina ◽  
Akiharu Ueki ◽  
...  
Keyword(s):  
Chemoenzymatic Synthesis ◽  
Complex Type ◽  
Glycoprotein Synthesis ◽  
Saposin C

scholarly journals Endo-F3 Glycosynthase Mutants Enable Chemoenzymatic Synthesis of Core-fucosylated Triantennary Complex Type Glycopeptides and Glycoproteins

2016 ◽  
Vol 291 (17) ◽  
pp. 9356-9370 ◽  
Author(s):  
John P. Giddens ◽  
Joseph V. Lomino ◽  
Mohammed N. Amin ◽  
Lai-Xi Wang
Keyword(s):  
Chemoenzymatic Synthesis ◽  
Complex Type

Chemoenzymatic Synthesis of the Immunoglobulin Domain of Tim-3 Carrying a Complex-Type N-Glycan by Using a One-pot Ligation

2013 ◽  
Vol 52 (37) ◽  
pp. 9733-9737 ◽  
Author(s):  
Yuya Asahina ◽  
Shigehiro Kamitori ◽  
Toshifumi Takao ◽  
Nozomu Nishi ◽  
Hironobu Hojo
Keyword(s):  
Chemoenzymatic Synthesis ◽  
Complex Type ◽  
One Pot ◽  
Immunoglobulin Domain

Chemoenzymatic Synthesis of the Immunoglobulin Domain of Tim-3 Carrying a Complex-Type N-Glycan by Using a One-pot Ligation

2013 ◽  
Vol 125 (37) ◽  
pp. 9915-9919 ◽  
Author(s):  
Yuya Asahina ◽  
Shigehiro Kamitori ◽  
Toshifumi Takao ◽  
Nozomu Nishi ◽  
Hironobu Hojo
Keyword(s):  
Chemoenzymatic Synthesis ◽  
Complex Type ◽  
One Pot ◽  
Immunoglobulin Domain

A One-Pot Chemoenzymatic Synthesis of (2S,4R)-4-Methylproline Enables the First Total Synthesis of Antiviral Lipopeptide Cavinafungin B

2018 ◽  
Author(s):  
Christian R. Zwick ◽  
Hans Renata
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Complex Molecule ◽  
Molecular Target ◽  
Chemoenzymatic Synthesis ◽  
General Strategy ◽  
One Pot

We report an efficient ten-step synthesis of antiviral natural product cavinafungin B in 37% overall yield. By leveraging a one-pot chemoenzymatic synthesis of (2S,4R)-4-methylproline and oxazolidine-tethered (Rink-Boc-ATG-resin) SPPS methodology, the assembly of our molecular target could be conducted in an efficient manner.This general strategy could prove amenable to the construction of other natural and unnatural linear lipopeptides. The value of incorporating biocatalytic steps in complex molecule synthesis is highlighted by this work.

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