Expedited Approach to the Vitamin Dtrans-Hydrindane Building Block from the Hajos Dione. Comparative Study on Various Methods for the Selective Deoxygenation of One of the Hydroxy Groups in a Diol

2007 ◽  
Vol 72 (14) ◽  
pp. 5276-5284 ◽  
Author(s):  
Paweł Chochrek ◽  
Jerzy Wicha
Keyword(s):  
Comparative Study ◽  
Building Block ◽  
Hydroxy Groups ◽  
Selective Deoxygenation

scholarly journals Changed reactivity of secondary hydroxy groups in C8-modified adenosine – lessons learned from silylation

2020 ◽  
Vol 16 ◽  
pp. 2854-2861
Author(s):  
Jennifer Frommer ◽  
Sabine Müller
Keyword(s):  
Building Block ◽  
Rna Structure ◽  
Building Blocks ◽  
Structure And Function ◽  
Lessons Learned ◽  
Modified Oligonucleotides ◽  
Synthetic Pathway ◽  
Protection Scheme ◽  
And Function ◽  
Hydroxy Groups

Synthesis of site-specifically modified oligonucleotides has become a major tool for RNA structure and function studies. Reporter groups or specific functional entities are required to be attached at a pre-defined site of the oligomer. An attractive strategy is the incorporation of suitably functionalized building blocks that allow post-synthetic conjugation of the desired moiety. A C8-alkynyl-modified adenosine derivative was synthesized, reviving an old synthetic pathway for iodination of purine nucleobases. Silylation of the C8-alkynyl-modified adenosine revealed unexpected selectivity of the two secondary sugar hydroxy groups, with the 3'-O-isomer being preferentially formed. Optimization of the protection scheme lead to a new and economic route to the desired C8-alkynylated building block and its incorporation in RNA.

Hexamethylenediamine (HMDA) from fossil- vs. bio-based routes: an economic and life cycle assessment comparative study

2015 ◽  
Vol 17 (10) ◽  
pp. 4760-4772 ◽  
Author(s):  
A. B. Dros ◽  
O. Larue ◽  
A. Reimond ◽  
F. De Campo ◽  
M. Pera-Titus
Keyword(s):  
Life Cycle Assessment ◽  
Life Cycle ◽  
Comparative Study ◽  
Building Block

A series of biobased routes are critically scrutinized for the production of hexamethylenediamine (HMDA) using 5-hydroxymethylene furfural (HMF) as intermediate building block.

Building Block Syntheses of Gallic Acid Monomers and Tris-(O-gallyl)-gallic Acid Dendrimers Chemically Attached to Graphite Powder: A Comparative Study of Their Uptake of Al(III) Ions

Langmuir ◽  
2010 ◽  
Vol 26 (3) ◽  
pp. 1776-1785 ◽  
Author(s):  
Junju Ye ◽  
Poobalasingam Abiman ◽  
Alison Crossley ◽  
John H. Jones ◽  
Gregory G. Wildgoose ◽  
...  
Keyword(s):  
Comparative Study ◽  
Gallic Acid ◽  
Building Block ◽  
Graphite Powder

scholarly journals A Taxonomy of Blockchain Technologies: Principles of Identification and Classification

Ledger ◽  
2019 ◽  
Vol 4 ◽  
Author(s):  
Paolo Tasca ◽  
Claudio J. Tessone
Keyword(s):  
Comparative Study ◽  
Building Block ◽  
Building Blocks ◽  
Bottom Up ◽  
Navigation Tool

A comparative study across the most widely known blockchain technologies is conducted with a bottom-up approach. Blockchains are deconstructed into their building blocks. Each building block is then hierarchically classified into main and subcomponents. Then, varieties of the subcomponents are identified and compared. A taxonomy tree is used to summarise the study and provide a navigation tool across different blockchain architectural configurations.

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