Heterogeneous Diazo-Transfer Reaction:  A Facile Unmasking of Azide Groups on Amine-Functionalized Insoluble Supports for Solid-Phase Synthesis

2006 ◽  
Vol 71 (26) ◽  
pp. 9791-9796 ◽  
Author(s):  
A. K. Oyelere ◽  
P. C. Chen ◽  
L. P. Yao ◽  
N. Boguslavsky
Keyword(s):  
Transfer Reaction ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Amine Functionalized ◽  
Diazo Transfer Reaction

scholarly journals Mono-amine Functionalized Phthalocyanines: Microwave-Assisted Solid-Phase Synthesis and Bioconjugation Strategies

2009 ◽  
Vol 74 (24) ◽  
pp. 9280-9286 ◽  
Author(s):  
S. Sibel Erdem ◽  
Irina V. Nesterova ◽  
Steven A. Soper ◽  
Robert P. Hammer
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Microwave Assisted ◽  
Amine Functionalized

Synthesis and Screening of A DNA-Encoded Library of Non-Peptidic Macrocycles

2020 ◽  
Author(s):  
Eric Koesema ◽  
Animesh Roy ◽  
Nicholas G. Paciaroni ◽  
Thomas Kodadek
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Cell Permeability ◽  
Phase Synthesis ◽  
Protein Ligands ◽  
High Affinity ◽  
Scaffold Diversity

There is considerable interest in the development of libraries of non-peptidic macrocycles as a source of ligands for difficult targets. We report here the solid-phase synthesis of a DNA-encoded library of several hundred thousand thioether-linked macrocycles. The library was designed to be highly diverse with respect to backbone scaffold diversity and to minimize the number of amide N-H bonds, which compromise cell permeability. The utility of the library as a source of protein ligands is demonstrated through the isolation of compounds that bind streptavidin, a model target, with high affinity.

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