scholarly journals Sigmatropic Rearrangements as Tools for Amino Acid and Peptide Modification:  Application of the Allylic Sulfur Ylide Rearrangement to the Preparation of Neoglycoconjugates and Other Conjugates

2006 ◽  
Vol 71 (24) ◽  
pp. 9172-9177 ◽  
Author(s):  
David Crich ◽  
Yekui Zou ◽  
Franck Brebion
Keyword(s):  
Amino Acid ◽  
Sigmatropic Rearrangements ◽  
Peptide Modification ◽  
Sulfur Ylide

scholarly journals Tetrazine-Containing Amino Acid for Peptide Modification and Live Cell Labeling

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0141918 ◽  
Author(s):  
Zhongqiu Ni ◽  
Lanxia Zhou ◽  
Xu Li ◽  
Jing Zhang ◽  
Shouliang Dong
Keyword(s):  
Amino Acid ◽  
Live Cell ◽  
Cell Labeling ◽  
Peptide Modification ◽  
Live Cell Labeling

α-(Disilylallenyl) α-amino acid derivatives from the Claisen rearrangement of propargyl glycinates

2009 ◽  
Vol 74 (6) ◽  
pp. 927-934 ◽  
Author(s):  
Mustafa Mohamed ◽  
Michael A. Brook
Keyword(s):  
Crystal Structure ◽  
Amino Acid ◽  
Good Yield ◽  
Claisen Rearrangement ◽  
Crystal Structure Analysis ◽  
Amino Acid Derivatives ◽  
X Ray ◽  
Sigmatropic Rearrangements ◽  
Acid Methyl ◽  
Glycine Derivatives

Silylpropargyl glycinate esters undergo [3,3]-sigmatropic rearrangements to give 2-(disilylallenyl)glycine derivatives, interesting highly functional synthons, in moderate to good yield (30 to 85%) and in high diastereoselectivity when directed by a large silylpropargyl group (9:1 to 22:1). The highly functional amino acid, methyl (R)-2-(Boc-amino)-3,5-bis(trimethylsilyl)hexa-3,4-dienoate was isolated and characterized by X-ray crystal structure analysis.

scholarly journals Hexafluoraceton als Schutzgruppen- und Aktivierungsreagenz in der Aminosäure- und Peptidchemie N-Substituierte Glycinderivate aus Iminodiessigsäure/Application of Hexafluoroacetone as Protecting and Activating Reagent in Amino Acid and Peptide Chemistry N -Substituted Glycine Derivatives from Iminodiacetic Acid

1993 ◽  
Vol 48 (1) ◽  
pp. 107-120 ◽  
Author(s):  
Klaus Burger ◽  
Horst Neuhauser ◽  
Anteneh Worku
Keyword(s):  
Amino Acid ◽  
Dicarboxylic Acid ◽  
Iminodiacetic Acid ◽  
Peptide Chemistry ◽  
Peptide Modification ◽  
Glycine Derivatives ◽  
Derivatives Of

3-Carboxymethyl-2,2-bis(trifluoromethyl)-oxazolidin-5-one 2, obtained on reaction of iminodiacetic acid 1 and hexafluoroacetone, represents a preparatively useful intermediate for the synthesis of unsymmetrically substituted derivatives of the dicarboxylic acid 1. The N-substituted glycine derivatives obtained are interesting candidates for peptide modification.

The staining pattern of the tropomyosin sequence is displayed in a new paracrystal

1986 ◽  
Vol 44 ◽  
pp. 150-151
Author(s):  
M.K. Lamvik ◽  
L.L. Klatt
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Staining Pattern ◽  
Banding Patterns ◽  
Mass Thickness ◽  
New Form

Tropomyosin paracrystals have been used extensively as test specimens and magnification standards due to their clear periodic banding patterns. The paracrystal type discovered by Ohtsuki1 has been of particular interest as a test of unstained specimens because of alternating bands that differ by 50% in mass thickness. While producing specimens of this type, we came across a new paracrystal form. Since this new form displays aligned tropomyosin molecules without the overlaps that are characteristic of the Ohtsuki-type paracrystal, it presents a staining pattern that corresponds to the amino acid sequence of the molecule.

Electron probe x-ray microanalysis and electron microscopy of amino acid absorption and transport by the small intestine: inhibition by chemical poisons and correlation to the elemental composition of the epithelial cells

1986 ◽  
Vol 44 ◽  
pp. 134-135
Author(s):  
A. J. Tousimis
Keyword(s):  
Small Intestine ◽  
Amino Acid ◽  
Epithelial Cells ◽  
Elemental Composition ◽  
Isotope Labeling ◽  
Structural Components ◽  
X Ray ◽  
Human Small Intestine ◽  
Transport Studies

The elemental composition of amino acids is similar to that of the major structural components of the epithelial cells of the small intestine and other tissues. Therefore, their subcellular localization and concentration measurements are not possible by x-ray microanalysis. Radioactive isotope labeling: I131-tyrosine, Se75-methionine and S35-methionine have been successfully employed in numerous absorption and transport studies. The latter two have been utilized both in vitro and vivo, with similar results in the hamster and human small intestine. Non-radioactive Selenomethionine, since its absorption/transport behavior is assumed to be the same as that of Se75- methionine and S75-methionine could serve as a compound tracer for this amino acid.

Immunoelectron microscope detection of C-type natriuretic peptide in normal human atrial tissue

1993 ◽  
Vol 51 ◽  
pp. 388-389
Author(s):  
Chi-Ming Wei ◽  
Margaret Hukee ◽  
Christopher G.A. McGregor ◽  
John C. Burnett
Keyword(s):  
Amino Acid ◽  
Natriuretic Peptide ◽  
Vascular Tone ◽  
Cardiac Tissue ◽  
Ring Structure ◽  
Terminal Amino Acid ◽  
Amino Acid Peptide ◽  
Normal Human ◽  
Terminal Amino ◽  
The Brain

C-type natriuretic peptide (CNP) is a newly identified peptide that is structurally related to atrial (ANP) and brain natriuretic peptide (BNP). CNP exists as a 22-amino acid peptide and like ANP and BNP has a 17-amino acid ring formed by a disulfide bond. Unlike these two previously identified cardiac peptides, CNP lacks the COOH-terminal amino acid extension from the ring structure. ANP, BNP and CNP decrease cardiac preload, but unlike ANP and BNP, CNP is not natriuretic. While ANP and BNP have been localized to the heart, recent investigations have failed to detect CNP mRNA in the myocardium although small concentrations of CNP are detectable in the porcine myocardium. While originally localized to the brain, recent investigations have localized CNP to endothelial cells consistent with a paracrine role for CNP in the control of vascular tone. While CNP has been detected in cardiac tissue by radioimmunoassay, no studies have demonstrated CNP localization in normal human heart by immunoelectron microscopy.

Amino Acid Metabolism

1979 ◽  
Vol 7 (1) ◽  
pp. 261-262
Author(s):  
E. V. ROWSELL
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

Increased expression of an amino acid transporter LAT1 in healing of acetic acid-induced chronic gastric ulcer in rats

2001 ◽  
Vol 120 (5) ◽  
pp. A153-A153
Author(s):  
S MIYAMOTO ◽  
K KATO ◽  
Y ISHII ◽  
S ASAI ◽  
T NAGAISHI ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Amino Acid ◽  
Amino Acid Transporter ◽  
Chronic Gastric Ulcer ◽  
Acid Transporter
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