Enantiomerically Pure Isophorone Diamine [3-(Aminomethyl)-3,5,5-trimethylcyclohexylamine]:  A Chiral 1,4-Diamine Building Block Made Available on Large Scale

2006 ◽  
Vol 71 (25) ◽  
pp. 9312-9318 ◽  
Author(s):  
Albrecht Berkessel ◽  
Katrin Roland ◽  
Michael Schröder ◽  
Jörg M. Neudörfl ◽  
Johann Lex
Keyword(s):  
Building Block ◽  
Large Scale ◽  
Enantiomerically Pure

A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

2019 ◽  
Vol 17 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Iaroslav Baglai ◽  
Michel Leeman ◽  
Richard M. Kellogg ◽  
Willem L. Noorduin
Keyword(s):  
Building Block ◽  
Rational Design ◽  
Large Scale ◽  
Enantiomerically Pure ◽  
Ripening Process ◽  
Simple Route ◽  
Chiral Component ◽  
Design And Application

A simple route to enantiomerically pure (S)-2-aminobutyramide – the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening process. The practical potential of the process is demonstrated on a large scale.

scholarly journals (R)-α-Aminoadipic Acid: A Versatile Precursor for the Synthesis of D-Amino Acids

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Amina Sadiq ◽  
Norbert Sewald
Keyword(s):  
Amino Acids ◽  
Building Block ◽  
Large Scale ◽  
Starting Material ◽  
Pipecolic Acid ◽  
Cephalosporin C ◽  
Enzymatic Cleavage ◽  
Enantiomerically Pure ◽  
Unusual Amino Acids ◽  
Derivatives Of

The ready accessibility of (R)-α-aminoadipic acid by enzymatic cleavage of cephalosporin C (CephC) in the production of 7-aminocephalosporanic acid (7-ACA) on a large scale makes it a favorable chiral pool building block for the synthesis of unusual amino acids. A route for the synthesis of C-5-alkenyl and C-6-alkylidene derivatives of (R)-pipecolic acid is described which utilizes (R)-α-aminoadipic acid as the enantiomerically pure starting material. Moreover, the synthesis of azido and triazolyl derivatives of (R)-α-aminoadipic acid is reported.

scholarly journals Enantiomerically Pure [2.2]Paracyclophane-4-thiol: A Planar Chiral Sulfur-Based Building Block Readily Available by Resolution with an Amino Acid Chiral Auxiliary

2016 ◽  
Vol 81 (9) ◽  
pp. 3961-3966 ◽  
Author(s):  
Adrien Vincent ◽  
Damien Deschamps ◽  
Thomas Martzel ◽  
Jean-François Lohier ◽  
Christopher J. Richards ◽  
...  
Keyword(s):  
Amino Acid ◽  
Building Block ◽  
Chiral Auxiliary ◽  
Enantiomerically Pure

ChemInform Abstract: A Large-Scale Synthesis of Enantiomerically Pure γ-Hydroxyorganochalcogenides.

ChemInform ◽  
2010 ◽  
Vol 41 (23) ◽  
pp. no-no
Author(s):  
Jefferson L. Princival ◽  
Morilo S. C. de Oliveira ◽  
Alcindo A. Dos Santos ◽  
Joao V. Comasseto
Keyword(s):  
Large Scale ◽  
Enantiomerically Pure ◽  
Large Scale Synthesis

ChemInform Abstract: A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC.

ChemInform ◽  
2010 ◽  
Vol 32 (33) ◽  
pp. no-no
Author(s):  
Derek A. Pflum ◽  
H. Scott Wilkinson ◽  
Gerald J. Tanoury ◽  
Donald W. Kessler ◽  
Hali B. Kraus ◽  
...  
Keyword(s):  
Large Scale ◽  
Chiral Hplc ◽  
Enantiomerically Pure ◽  
Large Scale Synthesis

scholarly journals CharTeC-Net: An Efficient and Lightweight Character-Based Convolutional Network for Text Classification

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Aboubakar Nasser Samatin Njikam ◽  
Huan Zhao
Keyword(s):  
Text Classification ◽  
Building Block ◽  
Large Scale ◽  
State Of The Art ◽  
Building Blocks ◽  
Training Data ◽  
Superior Performance ◽  
Classification Problems ◽  
Computationally Efficient ◽  
Convolutional Network

This paper introduces an extremely lightweight (with just over around two hundred thousand parameters) and computationally efficient CNN architecture, named CharTeC-Net (Character-based Text Classification Network), for character-based text classification problems. This new architecture is composed of four building blocks for feature extraction. Each of these building blocks, except the last one, uses 1 × 1 pointwise convolutional layers to add more nonlinearity to the network and to increase the dimensions within each building block. In addition, shortcut connections are used in each building block to facilitate the flow of gradients over the network, but more importantly to ensure that the original signal present in the training data is shared across each building block. Experiments on eight standard large-scale text classification and sentiment analysis datasets demonstrate CharTeC-Net’s superior performance over baseline methods and yields competitive accuracy compared with state-of-the-art methods, although CharTeC-Net has only between 181,427 and 225,323 parameters and weighs less than 1 megabyte.

Synthesis of an Enantiomerically Pure Building Block for the Synthesis of Hydroporphyrins

2007 ◽  
Vol 2007 (2) ◽  
pp. 249-257 ◽  
Author(s):  
Genevieve Etornam Adukpo ◽  
Tobias Borrmann ◽  
René Manski ◽  
Rosa I. Sáez Díaz ◽  
Wolf-Dieter Stohrer ◽  
...  
Keyword(s):  
Building Block ◽  
Enantiomerically Pure
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