Formal Total Synthesis of the Potent Renin Inhibitor Aliskiren:  Application of a SmI2-Promoted Acyl-like Radical Coupling

2006 ◽  
Vol 71 (13) ◽  
pp. 4766-4777 ◽  
Author(s):  
Karl B. Lindsay ◽  
Troels Skrydstrup
Keyword(s):  
Total Synthesis ◽  
Renin Inhibitor ◽  
Radical Coupling

ChemInform Abstract: Total Synthesis of “Aliskiren” (IV): The First Renin Inhibitor in Clinical Practice for Hypertension.

ChemInform ◽  
2010 ◽  
Vol 41 (36) ◽  
pp. no-no
Author(s):  
Stephen Hanessian ◽  
Sebastien Guesne ◽  
Etienne Chenard
Keyword(s):  
Clinical Practice ◽  
Total Synthesis ◽  
Renin Inhibitor

Unified Total Synthesis of Polyoxins J, L, and Fluorinated Analogues on the Basis of Decarbonylative Radical Coupling Reactions

2017 ◽  
Vol 129 (39) ◽  
pp. 12027-12031 ◽  
Author(s):  
Haruka Fujino ◽  
Masanori Nagatomo ◽  
Atmika Paudel ◽  
Suresh Panthee ◽  
Hiroshi Hamamoto ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Coupling Reactions ◽  
Radical Coupling

Total Synthesis of “Aliskiren”: The First Renin Inhibitor in Clinical Practice for Hypertension

2010 ◽  
Vol 12 (8) ◽  
pp. 1816-1819 ◽  
Author(s):  
Stephen Hanessian ◽  
Sébastien Guesné ◽  
Etienne Chénard
Keyword(s):  
Clinical Practice ◽  
Total Synthesis ◽  
Renin Inhibitor

Unified Total Synthesis of Polyoxins J, L, and Fluorinated Analogues on the Basis of Decarbonylative Radical Coupling Reactions

2017 ◽  
Vol 56 (39) ◽  
pp. 11865-11869 ◽  
Author(s):  
Haruka Fujino ◽  
Masanori Nagatomo ◽  
Atmika Paudel ◽  
Suresh Panthee ◽  
Hiroshi Hamamoto ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Coupling Reactions ◽  
Radical Coupling

Total synthesis of Δ9(12)-capnellene-8α,10α-diol

1982 ◽  
Vol 23 (52) ◽  
pp. 5471-5474
Author(s):  
G Pattenden
Keyword(s):  
Total Synthesis

Total synthesis of melleumins A and B and their analogs: Determination of stereochemistry and Wnt signal inhibitory activity

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
M Ishibashi ◽  
S Hanazawa ◽  
Y Uchino ◽  
X Li ◽  
MA Arai
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Wnt Signal
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