An Efficient Enantioselective Approach to Cyclic β-Amino Acid Derivatives via Olefin Metathesis Reactions

2006 ◽  
Vol 71 (8) ◽  
pp. 3317-3320 ◽  
Author(s):  
Giordano Lesma ◽  
Bruno Danieli ◽  
Alessandro Sacchetti ◽  
Alessandra Silvani
Keyword(s):  
Amino Acid ◽  
Olefin Metathesis ◽  
Amino Acid Derivatives ◽  
Metathesis Reactions

scholarly journals An Efficient Enantioselective Approach to Cyclic β-Amino Acid Derivatives via Olefin Metathesis Reactions.

ChemInform ◽  
2006 ◽  
Vol 37 (37) ◽  
Author(s):  
Giordano Lesma ◽  
Bruno Danieli ◽  
Alessandro Sacchetti ◽  
Alessandra Silvani
Keyword(s):  
Amino Acid ◽  
Olefin Metathesis ◽  
Amino Acid Derivatives ◽  
Metathesis Reactions

ChemInform Abstract: Synthesis of Fluorine-Containing Cyclic Amino Acid Derivatives via Ring Closing Olefin Metathesis.

ChemInform ◽  
2010 ◽  
Vol 30 (2) ◽  
pp. no-no
Author(s):  
S. N. OSIPOV ◽  
C. BRUNEAU ◽  
M. PICQUET ◽  
A. F. KOLOMIETS ◽  
P. H. DIXNEUF
Keyword(s):  
Amino Acid ◽  
Olefin Metathesis ◽  
Amino Acid Derivatives

Synthesis of fluorine-containing cyclic amino acid derivatives via ring closing olefin metathesis

1998 ◽  
pp. 2053-2054 ◽  
Author(s):  
Sergey N. Osipov ◽  
Alexey F. Kolomiets ◽  
Christian Bruneau ◽  
Michel Picquet ◽  
Pierre H. Dixneuf
Keyword(s):  
Amino Acid ◽  
Olefin Metathesis ◽  
Amino Acid Derivatives

Olefin-Bond Chemodifferentiation through Cross-Metathesis Reactions: A Stereocontrolled Approach to Functionalized β2,3 -Amino Acid Derivatives

2017 ◽  
Vol 2017 (14) ◽  
pp. 1894-1901 ◽  
Author(s):  
Márton Kardos ◽  
Loránd Kiss ◽  
Matti Haukka ◽  
Santos Fustero ◽  
Ferenc Fülöp
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Cross Metathesis ◽  
Metathesis Reactions

scholarly journals Application of Metathesis Reactions in the Synthesis and Transformations of Functionalized β-Amino Acid Derivatives

Synthesis ◽  
2018 ◽  
Vol 50 (18) ◽  
pp. 3571-3588 ◽  
Author(s):  
Loránd Kiss ◽  
Márton Kardos ◽  
Csaba Vass ◽  
Ferenc Fülöp
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Ring Opening ◽  
Amino Acid Derivatives ◽  
Ring Closing Metathesis ◽  
Ring Systems ◽  
Bond Functionalization ◽  
Cross Metathesis ◽  
Stereocontrolled Synthesis ◽  
Metathesis Reactions

Because of their biological relevance, cyclic β-amino acids have generated increasing interest and had significant impact in drug research over the past two decades. Their preparation and further functionalization towards new types of molecular entities have received large interest in synthetic and medicinal chemistry. Various types of metathesis reactions, such as ring-opening (ROM), ring-closing (RCM), or cross metathesis (CM) are used widely for access to either alicyclic β-amino acids or other densely functionalized derivatives of this group of compounds. This account intends to provide an insight into the most relevant synthetic routes to this class of derivatives with the application of metathesis reactions. The review focuses on the presentation of selective and stereocontrolled methodologies in view of versatility, robustness, limitations and efficiency.1 Introduction2 Synthesis and Transformation of Cyclic β-Amino Acids through Metathesis Reactions2.1 Synthesis of Five- and Six-Membered Cyclic β-Amino Acids by Ring-Closing Metathesis2.2 Synthesis of Five- and Six-Membered Cyclic β-Amino Acids by Cross Metathesis2.3 Synthesis of β-Amino Acids with Larger Ring Systems by Ring- Closing Metathesis2.4 Synthesis of β-Amino Acids with Condensed Ring Systems by Ring-Rearrangement Metathesis2.5 Stereocontrolled One-Step Synthesis of Functionalized Cispentacin and Transpentacin Derivatives2.5.1 Stereocontrolled Synthesis of Functionalized Cispentacin and Transpentacin Derivatives through Ring-Opening Metathesis of Norbornene β-Amino Acid Derivatives2.5.2 Stereocontrolled Synthesis of Functionalized Azetidinones and β-Amino Acid Derivatives from Condensed Ring β-Lactams by Ring-Opening Metathesis2.5.3 Carbon–Carbon Double Bond Functionalization of β-Amino Acid Derivatives and β-Lactams with α,β-Unsaturated Carbonyl Compounds through Cross Metathesis2.5.4 Synthesis of Functionalized β-Amino Acid Derivatives and β-Lactams through Chemoselective Cross Metathesis3 Conclusions and Outlook

Chemodiscrimination of Olefin Bonds Through Cross-Metathesis Reactions - Synthesis of Functionalized β-Lactam and β-Amino Acid Derivatives

2019 ◽  
Vol 2019 (31-32) ◽  
pp. 5285-5293 ◽  
Author(s):  
Melinda Nonn ◽  
Zsanett Benke ◽  
Santos Fustero ◽  
Ferenc Fülöp ◽  
Loránd Kiss
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Cross Metathesis ◽  
Metathesis Reactions
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