A New Class of ChiralP,N-Ligands and Their Application in Palladium-Catalyzed Asymmetric Allylic Substitution Reactions

2004 ◽  
Vol 69 (15) ◽  
pp. 5060-5064 ◽  
Author(s):  
Michael P. A. Lyle ◽  
Arun A. Narine ◽  
Peter D. Wilson
Keyword(s):  
Allylic Substitution ◽  
Substitution Reactions ◽  
New Class ◽  
Palladium Catalyzed

Chiral P,Olefin Ligands with Rotamers for Palladium-Catalyzed Asymmetric Allylic Substitution Reactions

Synlett ◽  
2020 ◽  
Author(s):  
Takashi Mino ◽  
Daiki Yamaguchi ◽  
Manami Kumada ◽  
Junpei Youda ◽  
Hironori Saito ◽  
...  
Keyword(s):  
Chiral Ligands ◽  
Allylic Substitution ◽  
Substitution Reactions ◽  
Palladium Catalyzed

We synthesized a series of phosphine–olefin-type chiral aminophosphines, and we confirmed that these each exists as two rotamers at the C(aryl)–N(amine) bond. We also investigated the ability of these aminophosphines to act as chiral ligands for Pd-catalyzed asymmetric allylic substitution reactions, such as the alkylation of allylic acetates with malonates or indoles, and we found they gave high enantio­selectivities (up to 98% ee).

Palladium-Catalyzed Asymmetric Allylic Substitution Reactions Using New Chiral Phosphinite−Oxazoline Ligands Derived fromd-Glucosamine

1999 ◽  
Vol 64 (26) ◽  
pp. 9374-9380 ◽  
Author(s):  
Koji Yonehara ◽  
Tomohiro Hashizume ◽  
Kenji Mori ◽  
Kouichi Ohe ◽  
Sakae Uemura
Keyword(s):  
Allylic Substitution ◽  
Substitution Reactions ◽  
Palladium Catalyzed ◽  
Oxazoline Ligands

ChemInform Abstract: Palladium Catalyzed Heck and Enantioselective Allylic Substitution Reactions Using Reverse Phase Silica Supports.

ChemInform ◽  
2010 ◽  
Vol 30 (49) ◽  
pp. no-no
Author(s):  
Michael S. Anson ◽  
Amin R. Mirza ◽  
Louise Tonks ◽  
Jonathan M. J. Williams
Keyword(s):  
Allylic Substitution ◽  
Substitution Reactions ◽  
Reverse Phase ◽  
Silica Supports ◽  
Palladium Catalyzed
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