Highly Regio- and Stereoselective Synthesis of Polysubstituted Cyclopropane Compounds via the Pd(0)-Catalyzed Coupling−Cyclization Reaction of 2-(2‘,3‘-Allenyl)malonates with Organic Halides

2004 ◽  
Vol 69 (19) ◽  
pp. 6463-6466 ◽  
Author(s):  
Shengming Ma ◽  
Ning Jiao ◽  
Qing Yang ◽  
Zilong Zheng
Keyword(s):  
Stereoselective Synthesis ◽  
Cyclization Reaction ◽  
Organic Halides

Stereoselective synthesis of O-tosyl azabicyclic derivatives via aza Prins reaction of endocyclic N-acyliminium ions: application to the total synthesis of (±)-epi-indolizidine 167B and 209D

2014 ◽  
Vol 12 (36) ◽  
pp. 7026-7035 ◽  
Author(s):  
Anil K. Saikia ◽  
Kiran Indukuri ◽  
Jagadish Das
Keyword(s):  
Total Synthesis ◽  
Stereoselective Synthesis ◽  
Cyclization Reaction ◽  
Diastereoselective Synthesis ◽  
Prins Reaction ◽  
Prins Cyclization ◽  
Acyliminium Ions

A diastereoselective synthesis of 4-O-tosyl piperidine containing azabicyclic derivatives has been established via Prins cyclization reaction. This protocol has been applied for the total synthesis of (±)-epi-indolizidine 167B and 209D.

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