Synthesis of 1-Amino-3-[(dihydroxyboryl)methyl]- cyclobutanecarboxylic Acid as a Potential Therapy Agent

2004 ◽  
Vol 69 (24) ◽  
pp. 8280-8286 ◽  
Author(s):  
George W. Kabalka ◽  
Min-Liang Yao
Keyword(s):  
Cyclobutanecarboxylic Acid

The vibrational spectra of cyclobutanecarboxylic acid

1972 ◽  
Vol 11 (3) ◽  
pp. 347-360 ◽  
Author(s):  
J.E. Katon ◽  
Roscoe O. Carter ◽  
Wilbur Yellin
Keyword(s):  
Vibrational Spectra ◽  
Cyclobutanecarboxylic Acid

Synthesis and Antiproliferative Activity of Spirocyclic Cyclodipeptides, Derivatives of 1-Amino-1-cyclobutanecarboxylic Acid

1993 ◽  
Vol 58 (12) ◽  
pp. 2987-2993 ◽  
Author(s):  
Jarmila Vinšová ◽  
Karel Kosař ◽  
Evžen Kasafírek
Keyword(s):  
Amino Acids ◽  
General Formula ◽  
Antiproliferative Activity ◽  
Screening Test ◽  
Proliferative Activity ◽  
Lower Activity ◽  
Chick Embryos ◽  
Cyclobutanecarboxylic Acid ◽  
Derivatives Of

A series of chiral spirocyclic cyclodipeptides of the general formula I was synthesized; the aim was to determine how the substitution of cyclobutane for cyclopentane in cyclo(-alanyl-1-amino-1-cyclopentanecarbonyl-) would influence the inhibition of the proliferative activity of the caudal morphogenic system (CMS) of Chick embryos. Spirocyclic cyclodipeptides Ia - Il were obtained by cyclization of linear dipeptides IIa - IIf, prepared by condensation of protected amino acids by DCCI method. The inhibition was investigated by the Chick Embryotoxicity Screening Test. The results show generally lower activity in the tested series, as compared with derivatives containing 1-amino-1-cyclopentanecarboxylic acid.

THE PREPARATION OF CYCLOBUTANECARBOXYLIC ACID

1949 ◽  
Vol 14 (6) ◽  
pp. 1036-1038 ◽  
Author(s):  
JAMES CASON ◽  
CHARLES F. ALLEN
Keyword(s):  
Cyclobutanecarboxylic Acid

scholarly journals Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Oxidative phosphorylation and mitochondrial oxidation of pyruvate, 3-hydroxybutyrate and tricarboxylic acid-cycle intermediates

1968 ◽  
Vol 110 (3) ◽  
pp. 499-509 ◽  
Author(s):  
A. E. Senior ◽  
H. S. A. Sherratt
Keyword(s):  
Oxidative Phosphorylation ◽  
Tricarboxylic Acid Cycle ◽  
Time Lag ◽  
Liver Mitochondria ◽  
Enoic Acid ◽  
Rat Liver Mitochondria ◽  
Pentanoic Acid ◽  
Low Concentrations ◽  
Cyclobutanecarboxylic Acid ◽  
Tricarboxylic Acid Cycle Intermediates

1. The effects of the hypoglycaemic compound pent-4-enoic acid, and of four structurally related non-hypoglycaemic compounds (pent-2-enoic acid, pentanoic acid, cyclopropanecarboxylic acid and cyclobutanecarboxylic acid), on several reactions in rat liver mitochondria were determined. 2. The use of manometric techniques for measurements of oxidations and of phosphorylation is critically discussed. 3. Pent-4-enoic acid and pentanoic acid uncoupled oxidative phosphorylation at low concentrations, but usually by not more than about 50%. 4. All the compounds, except cyclobutanecarboxylic acid, strongly inhibited the oxidation of pyruvate and 2-oxoglutarate, but the oxidations of succinate, citrate and 3-hydroxybutyrate were not strongly inhibited. 5. All the compounds, except cyclobutanecarboxylic acid, inhibited decarboxylation of [1−14C]pyruvate with ferricyanide as electron acceptor. 6. All the compounds, except pent-2-enoic acid, caused mitochondrial swelling after a time-lag.

Spirocyclic Dipeptides of 1-Amino-1-cyclohexanecarboxylic Acid

1994 ◽  
Vol 59 (1) ◽  
pp. 195-202 ◽  
Author(s):  
Jarmila Vinšová ◽  
Karel Kosař ◽  
Evžen Kasafírek
Keyword(s):  
General Formula ◽  
Screening Test ◽  
Methyl Esters ◽  
Cyclohexanecarboxylic Acid ◽  
Cyclobutanecarboxylic Acid

Spirocyclic cyclodipeptides with 1-amino-1-cyclohexanecarboxylic acid of the general formula cyclo(-Ach-A-), where A is Gly, L-Ala, D-Ala, L-Val, D-Val, L-Leu, D-Leu, D-Pgl, L-Phe or D-Phe, have been prepared by cyclization of the corresponding linear dipeptide methyl esters. The peptides cyclo(-L- or D-Ala-Ach-), cyclo(-L-Val-Ach-) and cyclo(-D-Leu-Ach-) show higher activity in the Chick Embryotoxicity Screening Test when compared with derivatives containing 1-amino-1-cyclopentanecarboxylic acid or 1-amino-1-cyclobutanecarboxylic acid.

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