Kinetic Study of the Aminolysis and Pyridinolysis ofO-Phenyl andO-EthylO-(2,4-Dinitrophenyl) Thiocarbonates. A Remarkable Leaving Group Effect

2004 ◽  
Vol 69 (7) ◽  
pp. 2411-2416 ◽  
Author(s):  
Enrique A. Castro ◽  
María Cubillos ◽  
Margarita Aliaga ◽  
Sandra Evangelisti ◽  
José G. Santos
Keyword(s):  
Kinetic Study ◽  
Group Effect ◽  
Leaving Group

scholarly journals Evidence for association-activation effects in reactions of papain from studies on its reactivity towards isomeric two-protonic-state reactivity probes

1979 ◽  
Vol 183 (2) ◽  
pp. 369-373 ◽  
Author(s):  
K Brocklehurst ◽  
J A L Herbert ◽  
R Norris ◽  
H Suschitzky
Keyword(s):  
Kinetic Study ◽  
Thiol Group ◽  
Probe Molecule ◽  
Leaving Group ◽  
Rate Maximum ◽  
Neutral Media ◽  
Imidazolium Ion

4-(N-Aminoethyl 4-pyridyl disulphide)-7-nitrobenzo-2-oxa-1,3-diazole was synthesized and evaluted as a two-protonic-state reactivity probe by kinetic study of its reactions with papain (EC 3.4.22.2) and with benzimidazol-2-ylmethanethiol. Evidence is presented to suggest that: (i) both this probe molecule and its 2-pyridyl isomer bind to papain; (ii) the binding is followed by a change in the environment of the thiol group of cysteine-25; (iii) the striking rate maximum in neutral media observed in the reaction of papain with the 2-pyridyl isomer but not with the 4-pyridyl isomer arises from association of the 2-pyridyl leaving group with the imidazolium ion of histidine-159.

Cis effect of dimethyl sulfide and the leaving group effect in reactions of the cationic complex chloro(dimethyl sulfide)(1,2-diaminoethane)platinum(II) chloride

1981 ◽  
Vol 20 (11) ◽  
pp. 3728-3730 ◽  
Author(s):  
Massimiliano. Bonivento ◽  
Luciano. Canovese ◽  
Lucio. Cattalini ◽  
Giampaolo. Marangoni ◽  
Gianni. Michelon ◽  
...  
Keyword(s):  
Dimethyl Sulfide ◽  
Group Effect ◽  
Cationic Complex ◽  
Leaving Group

Leaving group effect in the cleavage of picolinate esters catalyzed by hydroxy-functionalized metallomicelles

1994 ◽  
Vol 59 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Paolo Scrimin ◽  
Paolo Tecilla ◽  
Umberto Tonellato
Keyword(s):  
Group Effect ◽  
Leaving Group
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