Revision and Confirmation of the Regiochemistry of Isoxazoles Derived from Methyl Oleanonate and Lanost-8-en-3-one. Synthesis of a New Lanostane Triterpenoid with a Cyano-enone Functionality in Ring A

2003 ◽  
Vol 68 (12) ◽  
pp. 4991-4993 ◽  
Author(s):  
Yukiko Honda ◽  
Tadashi Honda ◽  
Sujata Roy ◽  
Gordon W. Gribble
Keyword(s):  
Lanostane Triterpenoid

A lanostane triterpenoid from Poria cocos

1992 ◽  
Vol 31 (7) ◽  
pp. 2548-2549 ◽  
Author(s):  
Tetsuro Shingu ◽  
Takaaki Tai ◽  
Akira Akahori
Keyword(s):  
Poria Cocos ◽  
Lanostane Triterpenoid

scholarly journals Lanostane Triterpenoid Metabolites from a Penares sp. Marine Sponge Protect Neuro-2a Cells against Paraquat Neurotoxicity

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5397
Author(s):  
Ekaterina A. Yurchenko ◽  
Sophia A. Kolesnikova ◽  
Ekaterina G. Lyakhova ◽  
Ekaterina S. Menchinskaya ◽  
Evgeny A. Pislyagin ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Cell Damage ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Neuroprotective Activity ◽  
Hsp70 Expression ◽  
Protective Effects ◽  
Intracellular Level ◽  
Intracellular Ros ◽  
Lanostane Triterpenoid

The results of an investigation of the protective effects of five lanostane triterpenoids: 3β-acetoxy-7β,8β-epoxy-5α-lanost-24-en-30,9α-olide (1), 3β-hydroxy-7β,8β-epoxy-5α-lanost-24-en- 30,9α-olide (2), 29-nor-penasterone (3), penasterone (4), and acetylpenasterol (5), from a marine sponge, Penares sp., against paraquat-induced neuroblastoma Neuro-2a cell damage, are described. The influence of all compounds on viability of the Neuro-2a cells treated with paraquat (PQ) was studied with MTT and fluorescein diacetate assays as well as propidium iodide straining. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of the compounds as well as their influence on reactive oxygen species (ROS) level and mitochondrial membrane potential in PQ-treated neuronal cells were analyzed. Finally, the effect of the compounds on intracellular level of heat shock protein 70 kDa (Hsp70) and neurite outgrowth in PQ-treated Neuro-2a cells were studied. Studied triterpenoids demonstrated protective effects against PQ-induced neurotoxicity associated with the ability to reduce ROS intracellular level and diminish mitochondrial dysfunction. Acetylpenasterol (5), as a more promising neuroprotective compound, significantly increased the viability of Neuro-2a cells incubated with PQ as well as decreased intracellular ROS level in these cells. Moreover, acetylpenasterol induced Hsp70 expression in PQ-treated cells. It was also shown to inhibit PQ-induced neurite loss and recovered the number of neurite-bearing cells. The relationship between neuroprotective activity of the investigated compounds 1–5 and their chemical structure was also discussed.

A New Cytotoxic Lanostane Triterpenoid from the Basidiomycete Hebeloma versipelle.

ChemInform ◽  
2006 ◽  
Vol 37 (23) ◽  
Author(s):  
Hong-Jun Shao ◽  
Chen Qing ◽  
Fei Wang ◽  
Yan-Li Zhang ◽  
Du-Qiang Luo ◽  
...  
Keyword(s):  
Lanostane Triterpenoid

Anti-allergic effect of inotodiol, a lanostane triterpenoid from Chaga mushroom, via selective inhibition of mast cell function

2020 ◽  
Vol 81 ◽  
pp. 106244 ◽  
Author(s):  
Thi Minh Nguyet Nguyen ◽  
Hong Son Le ◽  
Ba Vinh Le ◽  
Young Ho Kim ◽  
Inkyu Hwang
Keyword(s):  
Mast Cell ◽  
Cell Function ◽  
Selective Inhibition ◽  
Lanostane Triterpenoid ◽  
Allergic Effect

ChemInform Abstract: Schisanlactone G (I), a New 3,4-seco-Lanostane Triterpenoid from Schisandra sphenanthera.

ChemInform ◽  
2009 ◽  
Vol 40 (38) ◽  
Author(s):  
Rong Ren ◽  
Guo Jun Luo ◽  
Hong Mei Li ◽  
Zhao Yuan Wu ◽  
Hai Zhou Li ◽  
...  
Keyword(s):  
Schisandra Sphenanthera ◽  
Lanostane Triterpenoid

Schisanlactone G, a new 3,4-seco-lanostane triterpenoid from Schisandra sphenanthera

2009 ◽  
Vol 20 (5) ◽  
pp. 601-603 ◽  
Author(s):  
Rong Ren ◽  
Guo Jun Luo ◽  
Hong Mei Li ◽  
Zhao Yuan Wu ◽  
Hai Zhou Li ◽  
...  
Keyword(s):  
Schisandra Sphenanthera ◽  
Lanostane Triterpenoid

Synergistic use of NMR computation and quantitative interproton distance analysis in the structural determination of neokadcoccitane A, a rearranged triterpenoid featuring an aromatic ring D from Kadsura coccinea

2019 ◽  
Vol 6 (10) ◽  
pp. 1619-1626 ◽  
Author(s):  
Hou-Chao Xu ◽  
Kun Hu ◽  
Xiao-Huo Shi ◽  
Jian-Wei Tang ◽  
Xiao-Nian Li ◽  
...  
Keyword(s):  
Aromatic Ring ◽  
Structural Determination ◽  
Distance Analysis ◽  
Interproton Distance ◽  
Kadsura Coccinea ◽  
Lanostane Triterpenoid

A novel lanostane triterpenoid possessing an aromatic ring D, along with two novel norlanostane triterpenoids, were isolated from Kadsura coccinea.

Hyfraxins A and B, cytotoxic ergostane-type steroid and lanostane triterpenoid glycosides from the invasive ash dieback ascomycete Hymenoscyphus fraxineus

Steroids ◽  
2018 ◽  
Vol 135 ◽  
pp. 92-97 ◽  
Author(s):  
Frank Surup ◽  
Sandra Halecker ◽  
Manfred Nimtz ◽  
Sara Rodrigo ◽  
Barbara Schulz ◽  
...  
Keyword(s):  
Ash Dieback ◽  
Hymenoscyphus Fraxineus ◽  
Lanostane Triterpenoid ◽  
Triterpenoid Glycosides

A new lanostane triterpenoid from Ganoderma resinaceum

2019 ◽  
Vol 22 (11) ◽  
pp. 1095-1099
Author(s):  
Qiaofen Yang ◽  
Kejun He ◽  
Shiyu Qiu ◽  
Aoyi Zheng ◽  
Qiuyue Hu ◽  
...  
Keyword(s):  
Lanostane Triterpenoid
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