Rational Design, Synthesis, and Pharmacological Evaluation of 2-Azanorbornane-3-exo,5-endo-dicarboxylic Acid:  A Novel Conformationally Restricted Glutamic Acid Analogue

2003 ◽  
Vol 68 (4) ◽  
pp. 1489-1495 ◽  
Author(s):  
Lennart Bunch ◽  
Tommy Liljefors ◽  
Jeremy R. Greenwood ◽  
Karla Frydenvang ◽  
Hans Bräuner-Osborne ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Dicarboxylic Acid ◽  
Rational Design ◽  
Design Synthesis ◽  
Conformationally Restricted ◽  
Pharmacological Evaluation ◽  
Acid Analogue

In silico design, synthesis, characterization and pharmacological evaluation of captopril conjugates in the treatment of renal fibrosis

2019 ◽  
Vol 43 (1) ◽  
pp. 504-513 ◽  
Author(s):  
Swapnil Dashrath Jadhav ◽  
Prafulla Balkrishna Choudhari ◽  
Manish Sudesh Bhatia
Keyword(s):  
Glutamic Acid ◽  
In Silico ◽  
Renal Fibrosis ◽  
Design Synthesis ◽  
In Silico Design ◽  
Pharmacological Evaluation ◽  
P Application

Application of glutamic acid and taurine conjugates of captopril for kidney targeting.

Conformationally restricted glutamic acid analogues: stereoisomers of 1-aminospiro[3.3]heptane-1,6-dicarboxylic acid

RSC Advances ◽  
2014 ◽  
Vol 4 (21) ◽  
pp. 10894 ◽  
Author(s):  
Anton V. Chernykh ◽  
Dmytro S. Radchenko ◽  
Oleksandr O. Grygorenko ◽  
Dmitriy M. Volochnyuk ◽  
Svitlana V. Shishkina ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Dicarboxylic Acid ◽  
Conformationally Restricted

Synthesis of Unsaturated Analogues of Glutamic Acid: Amination of Trianions From Unsaturated Dicarboxylic Acids With Chloramine

1996 ◽  
Vol 49 (7) ◽  
pp. 785 ◽  
Author(s):  
RD Allan ◽  
RK Duke ◽  
TW Hambley ◽  
GAR Johnston ◽  
KN Mewett ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Double Bond ◽  
Glutamic Acid ◽  
Dicarboxylic Acid ◽  
Dicarboxylic Acids ◽  
Space Group ◽  
Conformationally Restricted ◽  
Convenient Synthesis

Trianions can be formed from dicarboxylic acids which contain a β,γ -double bond, and amination with chloramine yields β,γ-unsaturated α-amino acids. This methodology provides a convenient synthesis of amino acids that are inaccessible by other routes. (Z)-3-Phenylthiopent-2-enedioic acid and all four stable unsaturated analogues of the conformationally restricted glutamate analogue 1-aminocyclopentane-1,3-dicarboxylic acid have been synthesized to demonstrate the applicability of the method. The structure of one of the amino acid products, (�)-cis-1-aminocyclopent-4-ene-1,3-dicarboxylic acid (7), has been determined; it crystallizes in the space group P21/c, a 9.245(24), b 8.455(2), c 9.311(3) Ǻ, β 95.00(2)°, and the structure was refined to R 0.035 for 980 F.

scholarly journals Design, synthesis and pharmacological evaluation of conformationally restricted N-arylsulfonyl-3-aminoalkoxy indoles as a potential 5-HT6 receptor ligands

2011 ◽  
Vol 26 (3) ◽  
pp. 341-349 ◽  
Author(s):  
Ramakrishna V.S. Nirogia ◽  
Ramasastri Kambhampati ◽  
Anand V. Daulatabad ◽  
Parandhama Gudla ◽  
Mohammad Shaikh ◽  
...  
Keyword(s):  
Receptor Ligands ◽  
Design Synthesis ◽  
Conformationally Restricted ◽  
Pharmacological Evaluation

Design, synthesis, and pharmacological evaluation of potent xanthone dicarboxylic acid leukotriene B4 receptor antagonists

1993 ◽  
Vol 36 (12) ◽  
pp. 1726-1734 ◽  
Author(s):  
William T. Jackson ◽  
Robert J. Boyd ◽  
Larry L. Froelich ◽  
D. Mark Gapinski ◽  
Barbara E. Mallett ◽  
...  
Keyword(s):  
Dicarboxylic Acid ◽  
Leukotriene B4 ◽  
Receptor Antagonists ◽  
Design Synthesis ◽  
Pharmacological Evaluation ◽  
Leukotriene B4 Receptor
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