The Aminomethylation of Electron-Rich Aromatics with anN-Silyl-N,O-Acetal Catalyzed by a Metal Triflate-TMSCl System:  Facile Synthesis of Aromatic Primary Amines, 1-Aryl-trichloroethylamines

2003 ◽  
Vol 68 (2) ◽  
pp. 483-488 ◽  
Author(s):  
Norio Sakai ◽  
Maki Hirasawa ◽  
Toshihiro Hamajima ◽  
Takeo Konakahara
Keyword(s):  
Primary Amines ◽  
Facile Synthesis

ChemInform Abstract: A Facile Synthesis of β-Substituted α-Allenyl Primary Amines.

ChemInform ◽  
1987 ◽  
Vol 18 (45) ◽  
Author(s):  
J. R. MCCARTHY ◽  
C. L. BARNEY ◽  
D. P. MATTHEWS ◽  
T. M. BARGAR
Keyword(s):  
Primary Amines ◽  
Facile Synthesis

Electrooxidative rearrangement of tosylamino group: Facile synthesis of α-amino aldehydes from primary amines

1986 ◽  
Vol 27 (50) ◽  
pp. 6083-6086 ◽  
Author(s):  
Tatsuya Shono ◽  
Yoshihiro Matsumura ◽  
Susumu Katoh ◽  
Kenji Inoue ◽  
Yonetatsu Matsumoto
Keyword(s):  
Primary Amines ◽  
Facile Synthesis ◽  
Amino Aldehydes

Combining the incompatible: Block copolymers consecutively displaying activated esters and amines and their use as protein-repellent surface modifiers with multivalent biorecognition

2015 ◽  
Vol 6 (3) ◽  
pp. 476-486 ◽  
Author(s):  
Daniel Hoenders ◽  
Thomas Tigges ◽  
Andreas Walther
Keyword(s):  
Block Copolymers ◽  
Diblock Copolymers ◽  
Primary Amines ◽  
Facile Synthesis ◽  
Activated Esters ◽  
Surface Modifiers

We present the facile synthesis and orthogonal functionalization of diblock copolymers consisting of two incompatible segments, i.e. primary amines and activated esters, and demonstrate their use as protein-repellent brush layers with multivalent biorecognition.

scholarly journals Facile synthesis of N-doped graphene encapsulated Pd@N/C catalyst and its efficient application in cascade flow synthesis of amines

2021 ◽  
Author(s):  
Jianguo Liu ◽  
Jiangmin Sun ◽  
Yanpei Song ◽  
Shanshan Lin ◽  
Longlong Ma
Keyword(s):  
Heterogeneous Catalyst ◽  
Primary Amine ◽  
Flow Reactor ◽  
Building Blocks ◽  
Primary Amines ◽  
Facile Synthesis ◽  
Flow Synthesis ◽  
Nitrogen Doped ◽  
Doped Graphene ◽  
Excellent Stability

Abstract N-methylamines, as an important class of chemicals, crucial building blocks, have been widely used in pharmaceutical companies and materials synthesis. Transition metal-catalyzed synthesis of N-methylamines, especially the heterogeneous catalyzed N-methylation of amines via different C1 sources has become the most promising methodology, due to the environmentally friendlier process and the recyclable and easily accessible catalysts. However, these reactions generally require activated toxic methyl iodide or dimethyl sulfoxide, and homogeneous catalysts or Raney nickel catalyst. The synthesis of amines still suffering from narrow scopes of amines, harsh reaction conditions, low selectivity of the desired products, and against the requirements of atomic economy and sustainable green environment. Herein, we developed a novel facile synthesis of nitrogen-doped graphene encapsulated Pd@NC nanocatalysts. The resulting heterogeneous catalyst was active for the synthesis of amines (more than 83 examples, yield up to 99%). The nitrogen-doped effect was unlike the previous report that poisoned the metal, it could increase the interaction with the active metal resulting in excellent stability. As far as we know, for the first time, the developed N-doped graphene encapsulated Pd@NC nanocatalyst showed excellent stability and activity of amines synthesis in the 20 times’ recycling test, industrially applicable flow reactor 2880 minutes’ test, and 99% purity of primary amine and tertiary amines product preparation test. Moreover, we have also shown the high atomic economy and environmentally friendlier tandem flow synthesis of N, N-dimethylamine products via the combination of reduction of nitrobenzene and N-methylation of amines, using the single one Pd@NC nanocatalyst with H2O as the only by-product. Upon our knowledge, this is a novel example of primary amine and tertiary amine synthesis methodology with the combined cascade reaction and flow process of nitrobenzene reduction and primary amines N-methylation with a single heterogeneous catalyst.

A base-mediated self-propagative Lossen rearrangement of hydroxamic acids for the efficient and facile synthesis of aromatic and aliphatic primary amines

2016 ◽  
Vol 14 (38) ◽  
pp. 9046-9054 ◽  
Author(s):  
Naoya Ohtsuka ◽  
Moriaki Okuno ◽  
Yujiro Hoshino ◽  
Kiyoshi Honda
Keyword(s):  
Hydroxamic Acids ◽  
Primary Amines ◽  
Facile Synthesis

A variety of aromatic and aliphatic hydroxamic acids were converted to the corresponding primary amines via base-mediated rearrangement.

ChemInform Abstract: THE FACILE SYNTHESIS OF N-SUBSTITUTED PIPERIDINES FROM GLUTARALDEHYDE AND PRIMARY AMINES WITH TETRACARBONYLHYDRIDOFERRATE

1976 ◽  
Vol 7 (48) ◽  
pp. no-no
Author(s):  
Y. WATANABE ◽  
S. C. SHIM ◽  
T. MITSUDO ◽  
M. YAMASHITA ◽  
Y. TAKEGAMI
Keyword(s):  
Primary Amines ◽  
Facile Synthesis
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