Desymmetrization of a Centrosymmetric Diepoxide:  Efficient Synthesis of a Key Intermediate in a Total Synthesis of Hemibrevetoxin B

2003 ◽  
Vol 68 (3) ◽  
pp. 747-753 ◽  
Author(s):  
Joanne M. Holland ◽  
Mark Lewis ◽  
Adam Nelson
Keyword(s):  
Total Synthesis ◽  
Efficient Synthesis ◽  
Hemibrevetoxin B

scholarly journals A Convergent Total Synthesis of Hemibrevetoxin B.

ChemInform ◽  
2003 ◽  
Vol 34 (45) ◽  
Author(s):  
Armen Zakarian ◽  
Alexandre Batch ◽  
Robert A. Holton
Keyword(s):  
Total Synthesis ◽  
Hemibrevetoxin B

Toward the Total Synthesis of Phorboxazole B (II): An Efficient Synthesis of the C20?C46 Segment (I).

ChemInform ◽  
2005 ◽  
Vol 36 (12) ◽  
Author(s):  
De Run Li ◽  
Cai Yun Sun ◽  
Ce Su ◽  
Guo-Qiang Lin ◽  
Wei-Shan Zhou
Keyword(s):  
Total Synthesis ◽  
Efficient Synthesis ◽  
Phorboxazole B

Formal Total Synthesis of Hemibrevetoxin B via the Intramolecular Allylation Followed by Ring-Closing Metathesis

Heterocycles ◽  
2007 ◽  
Vol 74 (1) ◽  
pp. 617 ◽  
Author(s):  
Isao Kadota ◽  
Takashi Abe ◽  
Yukako Ishitsuka ◽  
Abeda S. Touchy ◽  
Ryoko Nagata ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Ring Closing Metathesis ◽  
Hemibrevetoxin B

Total synthesis of (+)-herboxidiene/GEX 1A

2017 ◽  
Vol 15 (8) ◽  
pp. 1842-1862 ◽  
Author(s):  
Alejandro Gómez-Palomino ◽  
Miquel Pellicena ◽  
Katrina Krämer ◽  
Pedro Romea ◽  
Fèlix Urpí ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Aldol Reactions ◽  
Efficient Synthesis

An efficient synthesis of herboxidiene is granted from highly stereoselective aldol reactions from two lactate-derived ketones and an oxa-Michael cyclization.

scholarly journals A Concise and Efficient Total Synthesis of α-Mangostin and β-Mangostin from Garcinia Mangostana

2013 ◽  
Vol 8 (8) ◽  
pp. 1934578X1300800
Author(s):  
Dandan Xu ◽  
Ying Nie ◽  
Xizhou Liang ◽  
Ling Ji ◽  
Songyuan Hu ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Wittig Reaction ◽  
Claisen Rearrangement ◽  
Practical Approach ◽  
Efficient Synthesis ◽  
Garcinia Mangostana ◽  
Diverse Groups

The concise, efficient synthesis of α-mangostin is described in eight simple steps with 8.3% overall yield. Highlights include a practical approach to construct the isopentene groups and other diverse groups at C–2 and C–8 of the xanthene skeleton through Claisen rearrangement and Wittig reaction. Meanwhile the first total synthesis of β-mangostin is presented with a similar approach.

scholarly journals Study on the total synthesis of velbanamine: Chemoselective dioxygenation of alkenes with PIFA via a stop-and-flow strategy

2013 ◽  
Vol 9 ◽  
pp. 983-990 ◽  
Author(s):  
Huili Liu ◽  
Kuan Zheng ◽  
Xiang Lu ◽  
Xiaoxia Wang ◽  
Ran Hong
Keyword(s):  
Total Synthesis ◽  
Synthetic Approach ◽  
Efficient Synthesis

A “stop-and-flow” strategy was developed for the chemoselective dioxygenation of alkenes with a PIFA-initiated cyclization. This method is conceived for the desymmetrization of seco-diene, and a series of substituted 5-hydroxymethyl-γ-lactones were constructed after hydrolysis. This strategy also differentiates terminally substituted alkenes and constitutes a potentially novel synthetic approach for the efficient synthesis toward velbanamine.

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