Total Syntheses of [17]- and [18]Dehydrodesoxyepothilones B via a Concise Ring-Closing Metathesis-Based Strategy:  Correlation of Ring Size with Biological Activity in the Epothilone Series

2002 ◽  
Vol 67 (22) ◽  
pp. 7737-7740 ◽  
Author(s):  
Alexey Rivkin ◽  
Jon T. Njardarson ◽  
Kaustav Biswas ◽  
Ting-Chao Chou ◽  
Samuel J. Danishefsky
Keyword(s):  
Biological Activity ◽  
Ring Size ◽  
Ring Closing Metathesis ◽  
Total Syntheses

Enantioselective formal total syntheses of Clavukerin A and isoclavukerin A via a ring-closing metathesis reaction

2010 ◽  
Vol 21 (6) ◽  
pp. 746-750 ◽  
Author(s):  
Adusumilli Srikrishna ◽  
Vijendra H. Pardeshi ◽  
Gedu Satyanarayana
Keyword(s):  
Metathesis Reaction ◽  
Ring Closing Metathesis ◽  
Total Syntheses

Stereoselective Total Syntheses of (3R,5R)-Sonnerlactone and (3R,5S)-Sonnerlactone

2017 ◽  
Vol 12 (9) ◽  
pp. 1934578X1701200
Author(s):  
Supriya Ghanty ◽  
P. Rasvan Khan ◽  
B. V. Subba Reddy
Keyword(s):  
Malic Acid ◽  
Ring Closing Metathesis ◽  
Total Syntheses ◽  
Key Steps ◽  
Barbier Allylation

A highly convergent and concise total syntheses of (3 R,5 R)-Sonnerlactone and (3 R,5 S) Sonnerlactone from a readily available L-malic acid is described. The following series of reactions such as Barbier allylation, photochemical esterification and Ring Closing Metathesis (RCM) are utilized as key steps to accomplish their syntheses.

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