Practical Asymmetric Synthesis of Aprepitant, a Potent Human NK-1 Receptor Antagonist, via a Stereoselective Lewis Acid-Catalyzed Trans Acetalization Reaction

2002 ◽  
Vol 67 (19) ◽  
pp. 6743-6747 ◽  
Author(s):  
Matthew M. Zhao ◽  
James M. McNamara ◽  
Guo-Jie Ho ◽  
Khateeta M. Emerson ◽  
Zhiguo J. Song ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Asymmetric Synthesis ◽  
Lewis Acid ◽  
Acid Catalyzed ◽  
Acetalization Reaction

Practical Asymmetric Synthesis of Aprepitant (I), a Potent Human NK-1 Receptor Antagonist, via a Stereoselective Lewis Acid Catalyzed trans Acetalization Reaction.

ChemInform ◽  
2003 ◽  
Vol 34 (7) ◽  
Author(s):  
Matthew Zhao ◽  
James M. McNamara ◽  
Guo-Jie Ho ◽  
Khateeta M. Emerson ◽  
Zhiguo J. Song ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Asymmetric Synthesis ◽  
Lewis Acid ◽  
Acid Catalyzed ◽  
Acetalization Reaction

Asymmetric synthesis of N-phenylethyl-2-phenyldecahydroquinolin-4-ones via Lewis acid catalyzed imino-Diels–Alder reaction

2000 ◽  
Vol 11 (12) ◽  
pp. 2509-2523 ◽  
Author(s):  
Renée Paugam ◽  
Emmanuelle Valenciennes ◽  
Linda Le Coz-Bardol ◽  
Jean-Christophe Garde ◽  
Lya Wartski ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Lewis Acid ◽  
Alder Reaction ◽  
Diels Alder ◽  
Diels Alder Reaction ◽  
Acid Catalyzed

Glycosylation-Induced and Lewis Acid-Catalyzed Asymmetric Synthesis of β-N-Glycosidically Linked α-Aminophosphonic Acids Derivatives

2008 ◽  
Vol 350 (14-15) ◽  
pp. 2339-2344 ◽  
Author(s):  
Yadan Wang ◽  
Fei Wang ◽  
Yangyun Wang ◽  
Zhiwei Miao ◽  
Ruyu Chen
Keyword(s):  
Asymmetric Synthesis ◽  
Lewis Acid ◽  
Aminophosphonic Acids ◽  
Acid Catalyzed
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