Reactions of Hydro(pero)xy Derivatives of Polyunsaturated Fatty Acids/Esters with Nitrite Ions under Acidic Conditions. Unusual Nitrosative Breakdown of Methyl 13-Hydro(pero)xyoctadeca-9,11-dienoate to a Novel 4-Nitro-2-oximinoalk-3-enal Product

2002 ◽  
Vol 67 (4) ◽  
pp. 1125-1132 ◽  
Author(s):  
Alessandra Napolitano ◽  
Emanuela Camera ◽  
Mauro Picardo ◽  
Marco d'Ischia
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Acidic Conditions ◽  
Derivatives Of

ChemInform Abstract: Synthesis of Hydroperoxide and Perketal Derivatives of Polyunsaturated Fatty Acids as Potential Antimalarial Agents.

ChemInform ◽  
2010 ◽  
Vol 29 (36) ◽  
pp. no-no
Author(s):  
M. J. PITT ◽  
C. J. EASTON ◽  
T. A. ROBERTSON ◽  
L. M. KUMARATILAKE ◽  
A. FERRANTE ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Antimalarial Agents ◽  
Derivatives Of

Synthesis of hydroperoxide and perketal derivatives of polyunsaturated fatty acids as potential antimalarial agents

1998 ◽  
Vol 39 (24) ◽  
pp. 4401-4404 ◽  
Author(s):  
Michael J. Pitt ◽  
Christopher J. Easton ◽  
Thomas A. Robertson ◽  
Lakshmi M. Kumaratilake ◽  
Antonio Ferrante ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Antimalarial Agents ◽  
Derivatives Of

scholarly journals High Epoxidation Yields of Vegetable Oil Hydrolyzates and Methyl Esters by Selected Fungal Peroxygenases

2021 ◽  
Vol 8 ◽  
Author(s):  
Alejandro González-Benjumea ◽  
Gisela Marques ◽  
Owik M. Herold-Majumdar ◽  
Jan Kiebist ◽  
Katrin Scheibner ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
Methyl Esters ◽  
Saturated Fatty Acids ◽  
Industrial Applications ◽  
Monooxygenase Activity ◽  
Acidic Conditions ◽  
Oil Hydrolysis ◽  
Derivatives Of ◽  
Environmentally Friendly Production

Epoxides of vegetable oils and free and methylated fatty acids are of interest for several industrial applications. In the present work, refined rapeseed, sunflower, soybean, and linseed oils, with very different profiles of mono- and poly-unsaturated fatty acids, were saponified and transesterified, and the products treated with wild unspecific peroxygenases (UPOs, EC 1.11.2.1) from the ascomycete Chaetomium globosum (CglUPO) and the basidiomycete Marasmius rotula (MroUPO), as well as with recombinant UPO of the ascomycete Humicola insolens (rHinUPO), as an alternative to chemical epoxidation that is non-selective and requires strongly acidic conditions. The three enzymes were able of converting the free fatty acids and the methyl esters from the oils into epoxide derivatives, although significant differences in the oxygenation selectivities were observed between them. While CglUPO selectively produced “pure” epoxides (monoepoxides and/or diepoxides), MroUPO formed also hydroxylated derivatives of these epoxides, especially in the case of the oil hydrolyzates. Hydroxylated derivatives of non-epoxidized unsaturated fatty acids were practically absent in all cases, due to the preference of the three UPOs selected for this study to form the epoxides. Moreover, rHinUPO, in addition to forming monoepoxides and diepoxides of oleic and linoleic acid (and their methyl esters), respectively, like the other two UPOs, was capable of yielding the triepoxides of α-linolenic acid and its methyl ester. These enzymes appear as promising biocatalysts for the environmentally friendly production of reactive fatty-acid epoxides given their self-sufficient monooxygenase activity with selectivity toward epoxidation, and the ability to epoxidize, not only isolated pure fatty acids, but also complex mixtures from oil hydrolysis or transesterification containing different combinations of unsaturated (and saturated) fatty acids.

A randomized, double-blind, placebo-controlled study of polyunsaturated fatty acids efficacy in adolescents with anorexia nervosa

2020 ◽  
Vol 36 (2) ◽  
pp. 95-106
Author(s):  
Agnieszka M. Piróg-Balcerzak ◽  
Anna K. Bażyńska ◽  
Katarzyna Biernacka ◽  
Joanna Brągoszewska ◽  
Lidia Popek ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Anorexia Nervosa ◽  
Polyunsaturated Fatty Acids ◽  
Small Sample Size ◽  
Small Sample ◽  
Female Adolescent ◽  
Eating Attitude ◽  
Controlled Study ◽  
Omega 3 ◽  
Eat 26

Objective. Omega–3 polyunsaturated fatty acids (PUFAs) were tested in adolescent depression and in several neurodevelopmental disorders with partial success. Anorexia nervosa (AN) is characterised by deficiencies in fatty food intake and frequent comorbidity, including depressive and cognitive symptoms. Thus supplementation with PUFAs may be beneficial in this group of patients. The aim of the study was to assess whether PUFAs as an add-on treatment is associated with better improvement of body mass index (BMI) and psychopathological symptoms than placebo in patients with AN. Method. 61 female adolescent inpatients with AN were randomly allocated to omega–3 PUFAs supplementation or placebo for 10 weeks. Patients also participated in the behavioural programme and eclectic psychotherapy (treatment as usual, TAU). At baseline and follow-up visits, patients’ BMI and psychopathology were assessed with Clinical Global Impression Scale (CGI), Patient Global Impression Scale (PGI), and Eating Attitude Test (EAT-26). Results. After 10 weeks, both groups showed improvement in all parameters. Improvement in CGI scores was observed greater in placebo vs. PUFA-s group (p = 0.015) while other differences were not statistically significant. Omega–3 PUFAs supplementation appears not to be effective as an add-on treatment in inpatient adolescent girls with anorexia nervosa. Conclusions. The results should be analysed with caution due to small sample size and heterogeneity in TAU. As the TAU turned out to be highly effective, additional therapeutic effect of PUFA might not be visible. Nevertheless, that does not explain the tendency for better improvement in the placebo group.

Polyunsaturated fatty acids and phytoestrogens modulate osteoclastogenesis and bone resorption in raw 264.7 macrophages

2013 ◽  
Author(s):  
Natalie Shepherd ◽  
Jager Cassandre De ◽  
Abe Kasonga ◽  
Sumari Marais ◽  
Yuko Tousen ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Bone Resorption ◽  
Polyunsaturated Fatty Acids ◽  
Raw 264.7 ◽  
Raw 264.7 Macrophages
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