Conformational analysis of N-acyl derivatives of 1-aza-3-cyclohexanone

1979 ◽  
Vol 44 (18) ◽  
pp. 3225-3229 ◽  
Author(s):  
Jerry A. Hirsch
Keyword(s):  
Conformational Analysis ◽  
Derivatives Of ◽  
Acyl Derivatives

Conformational analysis about the N-N bond by N.M.R. spectroscopy: N'-sulphonyl derivatives of N-Aminobicyclo[2,2,1]hept-5-ene-endo-2,3-dicarboximide

1974 ◽  
Vol 27 (6) ◽  
pp. 1227 ◽  
Author(s):  
SM Verma ◽  
Rao C Koteswara
Keyword(s):  
Conformational Analysis ◽  
Conformational Changes ◽  
Ground States ◽  
Spectral Changes ◽  
Rotational Barriers ◽  
Tosyl Group ◽  
Derivatives Of ◽  
Acyl Derivatives

A series of N'-sulphonyl and N'-acyl derivatives of N-aminobicyclo[2,2,1]hept-5-ene-endo-2,3-dicarboximide have been synthesized and their conformations have been investigated by N.M.R.spectroscopy. The effect of the sulphonyl group at the exocyclic nitrogen on the conformational process about the N-N bond has been studied. Existence of non-planar ground states about the N-N bond in the N',N?-disulphonyl and N'-sulphonyl-N'-acyl derivatives has been demonstrated.Temperature-dependent spectral changes have been related to the conformational changes about the N-N bond. It has been shown that the N'-tosyl substituent assumes a preferred conformation about the N-SO2 bond; the aryl part of the tosyl group lies exo to the cage-moiety. The N'-tosyl-N'-aroyl derivatives also show a preferred conformation about the N'-aroyl bond, the aryl part of the aroyl group lying endo to the cage-moiety. The N'-acetyl-N'-aroyl derivatives have been shown toexhibit low rotational barriers about the N'-aroyl bond.

scholarly journals Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1608
Author(s):  
Stephen Lo ◽  
Euphemia Leung ◽  
Bruno Fedrizzi ◽  
David Barker
Keyword(s):  
Antiproliferative Activity ◽  
Biological Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Breast Cancer Cell Lines ◽  
Scavenging Activity ◽  
Plant Materials ◽  
Wide Range ◽  
Derivatives Of ◽  
Acyl Derivatives

Quercetin is a flavonoid that is found in many plant materials, including commonly eaten fruits and vegetables. The compound is well known for its wide range of biological activities. In this study, 5-O-acyl derivatives of quercetin were synthesised and assessed for their antiproliferative activity against the HCT116 colon cancer and MDA-MB-231 breast cancer cell lines; and their radical scavenging activity against the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical species. Four derivatives were found to have improved the antiproliferative activity compared to quercetin whilst retaining radical scavenging activity.

ChemInform Abstract: O-ACYL DERIVATIVES OF 2-PYRIDINALDOXIME

1978 ◽  
Vol 9 (52) ◽  
Author(s):  
P. YA. ROMANOVSKII ◽  
A. YU. KRIKIS ◽  
G. I. CHIPENS
Keyword(s):  
Derivatives Of ◽  
Acyl Derivatives
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