Utility of purinyl radicals in the synthesis of base-modified nucleosides and alkylpurines: 6-amino group replacement by hydrogen, chlorine, bromine, and iodine

1980 ◽  
Vol 45 (20) ◽  
pp. 3969-3974 ◽  
Author(s):  
Vasu Nair ◽  
Stephen G. Richardson
Keyword(s):  
Modified Nucleosides ◽  
Amino Group

Synthesis and properties of some gelatin derivatives with substituents at the amino group

1965 ◽  
Vol 15 (10) ◽  
pp. 479-488
Author(s):  
R. C. Clark ◽  
W. G. Cobbett ◽  
J. A. Gibbs ◽  
R. T. Jones ◽  
A. A. Leach ◽  
...  
Keyword(s):  
Amino Group

Aminocoumarins: A Privileged Precursor for the Synthesis of Fused Heterocycles

2019 ◽  
Vol 23 (9) ◽  
pp. 1045-1075 ◽  
Author(s):  
Saigal ◽  
Sumbulunnisan Shareef ◽  
Habibur Rahman ◽  
Md. Musawwer Khan
Keyword(s):  
Chemical Reactivity ◽  
Structural Systems ◽  
Natural Occurrence ◽  
Amino Group ◽  
Active Compounds ◽  
The Past ◽  
Fused Heterocycles

Aminocoumarins are one of the important core structural systems, present in several biologically and medicinally active compounds. Owing to its natural occurrence, potential pharmacological applications and remarkable versatility as a privileged precursor, several proficient synthetic protocols have been reported in the literature over the past years. The presence of an amino group and enamine carbon enhances its chemical reactivity and thus such functionality is repeatedly used for the construction of various fused and simple heterocycles. This review highlights the preparation of different aminocoumarins and their applications for the construction of a variety of five, six and eight membered fused heterocycles.

Substituent Effects on the Basicity of ortho-, meta- and para-substituted N1,N1-Dimethyl-N2-phenylformamidines in Ethanol and in Water

1992 ◽  
Vol 57 (1) ◽  
pp. 113-118
Author(s):  
Ewa Daniela Raczyńska
Keyword(s):  
Quantitative Analysis ◽  
Aqueous Ethanol ◽  
Substituent Effects ◽  
Amino Group

The relative δpKa values of ortho-, meta-, and para-substituted N1,N1-dimethyl-N2-phenylformamidines obtained in 95.6% aqueous ethanol have been compared with those in water. The comparison shows only some differences in the ortho substituent effects. The meta and para substituent effects in ethanol are not very different from those in water. Quantitative analysis of the experimental δpKa values based on the Taft equation has led to separation of the total electromeric effects into the inductive and mesomeric effects. As compared to the amino group in anilines, the formamidine group is more sensitive to the transmission of the inductive than the mesomeric effects.

Sign in / Sign up

Export Citation Format

Share Document