Single-pass zone refining preparation of an enantiomerically pure compound

1967 ◽  
Vol 32 (9) ◽  
pp. 2901-2903 ◽  
Author(s):  
Lowell G. Tensmeyer ◽  
P. W. Landis ◽  
Frederick J. Marshall
Keyword(s):  
Zone Refining ◽  
Pure Compound ◽  
Enantiomerically Pure ◽  
Single Pass

Synthetic Access to a Novel Binaphthyl Ligand Bearing a Phosphine and a Triazole Donor Site

2009 ◽  
Vol 64 (11-12) ◽  
pp. 1438-1448 ◽  
Author(s):  
Claudia May ◽  
Yu Sun ◽  
Gotthelf Wolmershäuser ◽  
Werner R. Thiel
Keyword(s):  
Crystal Structure ◽  
Coordination Chemistry ◽  
Structure Analysis ◽  
Donor Site ◽  
Crystal Structure Analysis ◽  
Pure Compound ◽  
Enantiomerically Pure ◽  
X Ray ◽  
First Time

The combination of a diphenylphospinyl and a triazol-3-yl unit was realized for the first time at a 1,1'-binaphthyl backbone. This novel type of P,N-ligand is accessible as an enantiomerically pure compound in just a few steps. First experiments on the coordination chemistry with palladium(II) chloride have been carried out. A series of intermediates and a binuclear palladium(II) complex could be characterized by X-ray crystal structure analysis

scholarly journals Microbial Synthesis of the Forskolin Precursor Manoyl Oxide in an Enantiomerically Pure Form

2014 ◽  
Vol 80 (23) ◽  
pp. 7258-7265 ◽  
Author(s):  
Morten T. Nielsen ◽  
Johan Andersen Ranberg ◽  
Ulla Christensen ◽  
Hanne Bjerre Christensen ◽  
Scott J. Harrison ◽  
...  
Keyword(s):  
Process Optimization ◽  
Microbial Cell ◽  
Pure Compound ◽  
Plant Metabolites ◽  
Microbial Synthesis ◽  
Enantiomerically Pure ◽  
Medicinal Compound ◽  
Microbial Cell Factories ◽  
Cell Factories ◽  
Unreliable Supply

ABSTRACTForskolin is a promising medicinal compound belonging to a plethora of specialized plant metabolites that constitute a rich source of bioactive high-value compounds. A major obstacle for exploitation of plant metabolites is that they often are produced in small amounts and in plants difficult to cultivate. This may result in insufficient and unreliable supply leading to fluctuating and high sales prices. Hence, substantial efforts and resources have been invested in developing sustainable and reliable supply routes based on microbial cell factories. Here, we report microbial synthesis of (13R)-manoyl oxide, a proposed intermediate in the biosynthesis of forskolin and other medically important labdane-type terpenoids. Process optimization enabled synthesis of enantiomerically pure (13R)-manoyl oxide as the sole metabolite, providing a pure compound in just two steps with a yield of 10 mg/liter. The work presented here demonstrates the value of a standardized bioengineering pipeline and the large potential of microbial cell factories as sources for sustainable synthesis of complex biochemicals.

High-resolution EM investigation about effect of stress on formation of ω-phase crystals in β-tttanium alloys

1996 ◽  
Vol 54 ◽  
pp. 1006-1007
Author(s):  
E. Sukedai ◽  
M. Shimoda ◽  
A. Fujita ◽  
H. Nishizawa ◽  
H. Hashimoto
Keyword(s):  
High Resolution ◽  
Titanium Alloys ◽  
High Resolution Electron Microscopy ◽  
Dark Field ◽  
Zone Refining ◽  
Ω Phase ◽  
Α Phase ◽  
Nucleation Sites ◽  
Resolution Electron ◽  
Bcc Structure

ω-phase particles formed in β-titanium alloys (bcc structure) act important roles to their mechanical properties such as ductility and hardness. About the ductility, fine ω-phase particles in β–titanium alloys improve the ductility, because ω-phase crystals becomes nucleation sites of α-phase and it is well known that (β+α) duplex alloys have higher ductility. In the present study, the formation sites and the formation mechanism of ω-phase crystals due to external stress and aging are investigated using the conventional and high resolution electron microscopy.A β-titanium alloy (Til5Mo5Zr) was supplied by Kobe Steel Co., and a single crystal was prepared by a zone refining method. Plates with {110} surface were cut from the crystal and were pressured hydrostatically, and stressed by rolling and tensile testing. Specimens for aging with tensile stress were also prepared from Ti20Mo polycrystals. TEM specimens from these specimens were prepared by a twin-jet electron-polishing machine. A JEM 4000EX electron microscope operated at 400k V was used for taking dark field and HREM images.

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