STUDIES IN SILICO-ORGANIC COMPOUNDS. XIV. ALKOXYL DERIVATIVES OF THE ISOMERIC CHLOROETHYLTRICHLOROSILANES

1951 ◽  
Vol 16 (3) ◽  
pp. 391-394 ◽  
Author(s):  
FREDERICK W. BOYE ◽  
HOWARD W. POST
Keyword(s):  
Organic Compounds ◽  
In Silico ◽  
Derivatives Of

Studies in Silico-Organic Compounds. XXVII. Derivatives of Methyltrichlorosilane

1952 ◽  
Vol 17 (10) ◽  
pp. 1400-1404 ◽  
Author(s):  
Christ Tamborski ◽  
Howard W. Post
Keyword(s):  
Organic Compounds ◽  
In Silico ◽  
Derivatives Of

Direct synthesis of organic derivatives of silicon using nonhalogenated organic compounds

1970 ◽  
Vol 9 (5) ◽  
pp. 1071-1075 ◽  
Author(s):  
William E. Newton ◽  
Eugene G. Rochow
Keyword(s):  
Organic Compounds ◽  
Direct Synthesis ◽  
Derivatives Of

scholarly journals Screening of Chloroquine, Hydroxychloroquine and Its Derivatives for Their Binding Affinity to Multiple SARS-CoV-2 Protein Drug Targets

2020 ◽  
Author(s):  
Mallikarjuna Nimgampalle ◽  
Vasudharani Devanthan ◽  
Ambrish Saxena
Keyword(s):  
Binding Affinity ◽  
In Silico ◽  
Drug Targets ◽  
Therapeutic Potential ◽  
Viral Proteins ◽  
Protein Drug ◽  
Potential Treatment ◽  
Health Authorities ◽  
Derivatives Of

Recently Chloroquine and its derivative Hydroxychloroquine have garnered enormous interest amongst the clinicians and health authorities’ world over as a potential treatment to contain COVID-19 pandemic. The present research aims at investigating the therapeutic potential of Chloroquine and its potent derivative Hydroxychloroquine against SARS-CoV-2 viral proteins. At the same time we have screened some chemically synthesized derivatives of Chloroquine and compared their binding efficacy with chemically synthesized Chloroquine derivatives through <i>in silico</i>approaches. For the purpose of the study, we have selected some essential viral proteins and enzymes implicated in SARS-CoV-2 replication and multiplication as putative drug targets.<br>

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