STUDIES ON THE CHEMISTRY OF HETEROCYCLICS. XXIX.1BIAROMATICS IN THE THIOPHENE SERIES. II. THE SYNTHESIS OF BIPHENYL TYPE COMPOUNDS CONTAINING THE THIOPHENE RING.2

1955 ◽  
Vol 20 (10) ◽  
pp. 1363-1369 ◽  
Author(s):  
GEORGE N. JEAN ◽  
F. F. NORD
Keyword(s):  
Thiophene Ring ◽  
Thiophene Series

Tuning the luminescence efficiency by perfluorination of side chains in Eu3+ complexes with β-diketones of thiophene series

2021 ◽  
Author(s):  
Evgeniya Varaksina ◽  
Mikhail A. Kiskin ◽  
Konstantin A. Lyssenko ◽  
Lada N. Puntus ◽  
Vladislav Korshunov ◽  
...  
Keyword(s):  
Comparative Study ◽  
Thiophene Ring ◽  
Luminescent Properties ◽  
Side Chains ◽  
Side Group ◽  
Luminescence Efficiency ◽  
Thiophene Series ◽  
Gadolinium Complexes

A series of europium and gadolinium complexes comprising β-diketone moiety modified with a fluorinated side-group and thiophene ring have been designed, synthesized and a comparative study of their luminescent properties...

Reversible Oxidative-Addition and Reductive-Elimination of Thiophene from a Titanium Complex and Its Thermally-Induced Hydrodesulfurization Chemistry

2019 ◽  
Author(s):  
Alejandra Gomez-Torres ◽  
J. Rolando Aguilar-Calderón ◽  
Carlos Saucedo ◽  
Aldo Jordan ◽  
Alejandro J. Metta-Magaña ◽  
...  
Keyword(s):  
Dft Calculations ◽  
Ring Opening ◽  
Thiophene Ring ◽  
Oxidative Addition ◽  
Reductive Elimination ◽  
Thermally Induced ◽  
Titanium Complex

<p>The masked Ti(II) synthon (<sup>Ket</sup>guan)(<i>η</i><sup>6</sup>-Im<sup>Dipp</sup>N)Ti (<b>1</b>) oxidatively adds across thiophene to give ring-opened (<sup>Ket</sup>guan)(Im<sup>Dipp</sup>N)Ti[<i>κ</i><sup>2</sup>-<i>S</i>(CH)<sub>3</sub><i>C</i>H] (<b>2</b>). Complex <b>2</b> is photosensitive, and upon exposure to light, reductively eliminates thiophene to regenerate <b>1</b> – a rare example of early-metal mediated oxidative-addition/reductive-elimination chemistry. DFT calculations indicate strong titanium π-backdonation to the thiophene π*-orbitals leads to the observed thiophene ring opening across titanium, while a proposed photoinduced LMCT promotes the reverse thiophene elimination from <b>2</b>. Finally, pressurizing solutions of <b>2 </b>with H<sub>2</sub> (150 psi) at 80 °C leads to the hydrodesulfurization of thiophene to give the Ti(IV) sulfide (<sup>Ket</sup>guan)(Im<sup>Dipp</sup>N)Ti(S) (<b>3</b>) and butane. </p>

(Substituted)-benzo[b]thiophene-4-carboxamide Synthesis and Antiproliferative Activity Study

2020 ◽  
Vol 17 (5) ◽  
pp. 563-573 ◽  
Author(s):  
Chandrakant Dhondiram Pawar ◽  
Dattatraya Navnath Pansare ◽  
Devanand Baburao Shinde
Keyword(s):  
Anticancer Activity ◽  
Cell Lines ◽  
Proliferative Activity ◽  
Thiophene Ring ◽  
Amide Group ◽  
Peptide Coupling ◽  
Ic50 Value ◽  
Important Building Block ◽  
Mcf 7

Background: Thiophene ring forms important building block in medicinal chemistry. Literature reveals that thiophene ring in combination with different groups shows different activity. By keeping these things in mind we have designed and synthesized a new series of amide and sulfonamide coupled thiophene. A series of novel substituted 3-sulfamoylbenzo[b]thiophene-4- carboxamide molecules containing sulfonamide and amide group were designed, synthesized and used for anti-proliferative activity study. Methods: The final compounds 16-36 were synthesized by using series of reactions comprising sulfonation, sulfonamide coupling, hydrolysis and peptide coupling. The yields of compounds 16- 36 are in the range of 90-98%. The structures of the synthesized compounds were elucidated and confirmed by 1H NMR, 13C NMR, LCMS and the purity was checked through HPLC analysis. The compounds were further tested for their in vitro anticancer activity against a series of cell lines A549, HeLa, MCF-7 and Du-145. Results: The intermediates 8-13, 15 and final compounds 16-36 were synthesized in good yields. The synthesized compounds were further tested for their anticancer activity and most of compounds showed moderate to good anticancer activity against all four cell lines. Conclusion: We have synthesized 21 compounds and were screened for anticancer activity against MCF-7, HeLa, A-549 and Du-145 cancer cell lines. Most of the compounds were active for tested cell lines with IC50 value in the range of 1.81 to 9.73 μM. The compounds 18, 19, 21, 25, 30, 31 and 33 are most active in cell line data with IC50 value in the range of 1.81 to 2.52 μM.

Studies in the thiophene series. III. Anodic oxidation of 2-thenyl alcohol

1972 ◽  
Vol 37 (8) ◽  
pp. 2584-2588 ◽  
Author(s):  
M. Janda ◽  
J. Šrogl ◽  
M. Synáčková
Keyword(s):  
Anodic Oxidation ◽  
Thiophene Series

Transfer of inductive effect in thiophene series

1976 ◽  
Vol 41 (5) ◽  
pp. 1541-1550 ◽  
Author(s):  
M. Janda ◽  
J. Šrogl ◽  
M. Němec ◽  
K. Kalfus
Keyword(s):  
Inductive Effect ◽  
Thiophene Series

scholarly journals Thiophene-Based Trimers and Their Bioapplications: An Overview

Polymers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 1977
Author(s):  
Lorenzo Vallan ◽  
Emin Istif ◽  
I. Jénnifer Gómez ◽  
Nuria Alegret ◽  
Daniele Mantione
Keyword(s):  
Optical Properties ◽  
Medical Research ◽  
Turning Point ◽  
State Of The Art ◽  
Thiophene Ring ◽  
Functional Polymers ◽  
Direct Application ◽  
Synthetic Methods ◽  
Scientific Interest ◽  
Chemical Modifications

Certainly, the success of polythiophenes is due in the first place to their outstanding electronic properties and superior processability. Nevertheless, there are additional reasons that contribute to arouse the scientific interest around these materials. Among these, the large variety of chemical modifications that is possible to perform on the thiophene ring is a precious aspect. In particular, a turning point was marked by the diffusion of synthetic strategies for the preparation of terthiophenes: the vast richness of approaches today available for the easy customization of these structures allows the finetuning of their chemical, physical, and optical properties. Therefore, terthiophene derivatives have become an extremely versatile class of compounds both for direct application or for the preparation of electronic functional polymers. Moreover, their biocompatibility and ease of functionalization make them appealing for biology and medical research, as it testifies to the blossoming of studies in these fields in which they are involved. It is thus with the willingness to guide the reader through all the possibilities offered by these structures that this review elucidates the synthetic methods and describes the full chemical variety of terthiophenes and their derivatives. In the final part, an in-depth presentation of their numerous bioapplications intends to provide a complete picture of the state of the art.

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