Periselective addition of nitrile sulfides, nitrile oxides and diphenyldiazomethane to tetracyanoethylene

1976 ◽  
Vol 41 (4) ◽  
pp. 620-626 ◽  
Author(s):  
John E. Franz ◽  
Robert K. Howe ◽  
Helen K. Pearl
Keyword(s):  
Nitrile Oxides ◽  
Nitrile Sulfides

scholarly journals 1,3-Dipoles: Nitrile Imines, Nitrile Oxides and Nitrile Sulfides

Synlett ◽  
2012 ◽  
Vol 23 (04) ◽  
pp. 640-641
Author(s):  
Péter Ábrányi-Balogh
Keyword(s):  
Nitrile Oxides ◽  
Nitrile Imines ◽  
Nitrile Sulfides

Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently

2019 ◽  
Author(s):  
John Eaton ◽  
Richard A. Ruberto ◽  
Anneke Kramm ◽  
Vasanthi S. Viswanathan ◽  
Stuart Schreiber
Keyword(s):  
Molecular Mechanism ◽  
Mechanism Of Action ◽  
Therapeutic Target ◽  
Biologically Active ◽  
Drug Resistant ◽  
Nitrile Oxides ◽  
Molecular Mechanism Of Action

<div><div><div><p>GPX4 represents a promising yet difficult-to-drug therapeutic target for the treatment of, among others, drug-resistant cancers. While most GPX4 inhibitors rely on a chloroacetamide moiety to modify covalently the protein’s catalytic selenocysteine residue, the discovery and mechanistic elucidation of structurally diverse GPX4-inhibiting molecules has uncovered novel electrophilic warheads that bind and inhibit GPX4. Here we report our discovery that diacylfuroxans can act as masked nitrile oxides that inhibit GPX4 covalently. These observations illuminate a novel molecular mechanism of action for biologically active furoxans and also suggest that nitrile oxides may be uniquely suited to targeting GPX4.</p></div></div></div>

ChemInform Abstract: Synthesis of Stable Functionally-Substituted Nitrile Oxides in the Aromatic Series.

ChemInform ◽  
2010 ◽  
Vol 23 (50) ◽  
pp. no-no
Author(s):  
A. P. YAKUBOV ◽  
D. V. TSYGANOV ◽  
L. I. BELEN'KII ◽  
M. M. KRAYUSHKIN
Keyword(s):  
Nitrile Oxides ◽  
Aromatic Series
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