Inter- and intramolecular cyclization of bisdiazo ketones. Formation of the novel 3,3'-spirobi(bicyclo[3.1.0]hexane)-2,2'-dione system

1970 ◽  
Vol 35 (4) ◽  
pp. 1028-1034 ◽  
Author(s):  
S. Bien ◽  
D. Ovadia
Keyword(s):  
Intramolecular Cyclization ◽  
The Novel

Intramolecular cyclization–decyclization of new sterically hindered diiminophenol. Synthesis and coordination abilities

RSC Advances ◽  
2014 ◽  
Vol 4 (28) ◽  
pp. 14495-14500 ◽  
Author(s):  
Gleb A. Abakumov ◽  
Nikolay O. Druzhkov ◽  
Elena N. Egorova ◽  
Tatiana N. Kocherova ◽  
Andrey S. Shavyrin ◽  
...  
Keyword(s):  
Intramolecular Cyclization ◽  
The Novel ◽  
Cadmium Complexes ◽  
Coordination Type ◽  
Sterically Hindered

The novel benzoxazole I undergoes a fast intramolecular decyclization and demonstrates either a neutral or anionic coordination type in cadmium complexes.

Total Synthesis of ( ± )-α-Cubebene and ( ± )-β-Cubebene

1971 ◽  
Vol 49 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Edward Piers ◽  
Ronald W. Britton ◽  
William De Waal
Keyword(s):  
Total Synthesis ◽  
Intramolecular Cyclization ◽  
High Yield ◽  
Cupric Sulfate ◽  
The Novel

An efficient total synthesis of the racemic forms of the novel tricyclic sesquiterpenes α-cubebene (1) and β-cubebene (2) is described. The key step of this synthesis involved the cupric sulfate catalyzed intramolecular cyclization of the olefinic diazoketone 3, which produced, in high yield, ( ± )-β-cubebene norketone (24) and ( ± )-1,6-epi-β-cubebene norketone (25), in a ratio of approximately 3:5, respectively.

An unexpected formation of the novel 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton during the reaction of furfurylamine with maleimides and their bioprospection using a zebrafish embryo model

2013 ◽  
Vol 11 (3) ◽  
pp. 407-411 ◽  
Author(s):  
Carlos E. Puerto Galvis ◽  
Vladimir V. Kouznetsov
Keyword(s):  
Green Synthesis ◽  
Intramolecular Cyclization ◽  
Zebrafish Embryo ◽  
The Novel ◽  
Unexpected Formation ◽  
Novel Strategy

An unexpected intramolecular cyclization during the reaction of furfurylamine with maleimides is reported as a novel strategy for the efficient green synthesis of the 7-oxa-2-azabicyclo[2.2.1]hept-5-ene skeleton.

Synthesis of new condensed and cyclized coumarin derivatives

2007 ◽  
Vol 61 (3) ◽  
Author(s):  
S. Dekić ◽  
V. Dekić ◽  
B. Dekić ◽  
M. Dekić
Keyword(s):  
Acid Hydrolysis ◽  
Intramolecular Cyclization ◽  
13C Nmr ◽  
Catalytic Amount ◽  
The Novel ◽  
Coumarin Derivatives ◽  
1H And 13C Nmr

AbstractCondensation of 4-chloro-2-oxo-2H-chromene-3-carbonitrile with selected heteroarylamines in acetonitrile containing a catalytic amount of triethylamine, followed by intramolecular cyclization, gave the new coumarin derivatives with yields ranging from 43 % to 78 %. The novel compounds were subjected to acid hydrolysis giving the corresponding oxo derivatives in 66–70 % yield. The structural assignments of the synthesized compounds were based on elemental, IR, 1H and 13C NMR analyses.

Conjugate systems in the construction of heterocycles and quaternary stereocenters

2007 ◽  
Vol 79 (2) ◽  
pp. 181-191 ◽  
Author(s):  
Carlos González-Romero ◽  
Pablo Bernal ◽  
Fabiola Jiménez ◽  
María del Carmen Cruz ◽  
Aydeé Fuentes-Benites ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Intramolecular Cyclization ◽  
Regioselective Synthesis ◽  
The Novel ◽  
One Pot ◽  
Naturally Occurring ◽  
Novel Approach ◽  
Michael Acceptors ◽  
Quaternary Stereocenters ◽  
Synthetic Application

The synthetic application of 4,5-bis-alkylidene-1,3-oxazolidin-2-ones led to the efficient and regioselective synthesis of 2-(3H)-benzoxazolones and diarylamines with a short methodology. They were also valuable synthons in a total synthesis of naturally occurring carbazoles. New enantiopure 4-oxazoline-2-one and 4-methylene-2-oxazolidinone were prepared via a one-pot microwave (MW)-promoted condensation of α-ketols and an enantiopure isocyanate. These enamides were efficient nucleophiles when added to Michael acceptors to give a series of compounds with quaternary stereocenters in fairly good stereoisomeric ratios. The novel approach for the synthesis of benzofurans and indoles by intramolecular cyclization of enaminones has been applied in the preparation of furobenzofurans starting from benzo-bis-enaminones.

The novel steroidal glycoside from the dried bulb of Allium Macrostemon Bunge inhibits platelet activation

2010 ◽  
Vol 34 (8) ◽  
pp. S33-S33
Author(s):  
Wenchao Ou ◽  
Haifeng Chen ◽  
Yun Zhong ◽  
Benrong Liu ◽  
Keji Chen
Keyword(s):  
Platelet Activation ◽  
The Novel ◽  
Steroidal Glycoside ◽  
Allium Macrostemon
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