An Efficient, General Asymmetric Synthesis of Carbocyclic Nucleosides:  Application of an Asymmetric Aldol/Ring-Closing Metathesis Strategy

2000 ◽  
Vol 65 (25) ◽  
pp. 8499-8509 ◽  
Author(s):  
Michael T. Crimmins ◽  
Bryan W. King ◽  
William J. Zuercher ◽  
Allison L. Choy
Keyword(s):  
Asymmetric Synthesis ◽  
Carbocyclic Nucleosides ◽  
Ring Closing Metathesis ◽  
Asymmetric Aldol

Asymmetric synthesis of cyclic β-amino acids and cyclic amines via sequential diastereoselective conjugate addition and ring closing metathesis

Tetrahedron ◽  
2003 ◽  
Vol 59 (18) ◽  
pp. 3253-3265 ◽  
Author(s):  
Ann M Chippindale ◽  
Stephen G Davies ◽  
Keiji Iwamoto ◽  
Richard M Parkin ◽  
Christian A.P Smethurst ◽  
...  
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Conjugate Addition ◽  
Ring Closing Metathesis ◽  
Cyclic Amines

ChemInform Abstract: Asymmetric Synthesis of L-Cyclopentyl Carbocyclic Nucleosides.

ChemInform ◽  
2010 ◽  
Vol 28 (37) ◽  
pp. no-no
Author(s):  
P. WANG ◽  
L. A. AGROFOLIO ◽  
M. G. NEWTON ◽  
C. K. CHU
Keyword(s):  
Asymmetric Synthesis ◽  
Carbocyclic Nucleosides

Tandem allylboration-ring-closing metathesis reactions for the preparation of biologically active molecules

2003 ◽  
Vol 75 (9) ◽  
pp. 1263-1275 ◽  
Author(s):  
P. Veeraraghavan Ramachandran ◽  
M. Venkat Ram Reddy ◽  
Herbert C. Brown
Keyword(s):  
Organic Chemistry ◽  
Natural Products ◽  
Asymmetric Synthesis ◽  
Biologically Active ◽  
Cyclic Ethers ◽  
Ring Closing Metathesis ◽  
The Past ◽  
Metathesis Reactions

The development of asymmetric synthesis during the past two decades aided organic chemists considerably in the synthesis of complex natural products. Organoborane chemistry continues to play an important role in asymmetric synthesis. One of the important reactions that has become very common in the arsenal of synthetic chemists is allylboration and related reactions. Another important reaction that has recently attained enormous importance in organic chemistry is the ring-closing metathesis (RCM) reaction. Indeed, a combination of allylboration and RCM reactions provides an excellent route to cyclic ethers, lactones, lactams, etc. Herein, we describe a sequential asymmetric allylboration and RCM reaction protocol that has been utilized for the synthesis of several alpha-pyrone-containing natural products,particularly biologically active molecules.

Green Asymmetric Synthesis: β -Amino Alcohol-Catalyzed Direct Asymmetric Aldol Reactions in Aqueous Micelles

Chirality ◽  
2012 ◽  
Vol 25 (2) ◽  
pp. 119-125 ◽  
Author(s):  
Afroditi Pinaka ◽  
Georgios C. Vougioukalakis ◽  
Dimitra Dimotikali ◽  
Elina Yannakopoulou ◽  
Bezhan Chankvetadze ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Amino Alcohol ◽  
Aldol Reactions ◽  
Asymmetric Aldol ◽  
Aqueous Micelles
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