New methods and reagents in organic synthesis. 2. A facile conversion of alkyl aryl ketones to .alpha.-arylalkanoic acids using diphenyl phosphorazidate. Its application to a new synthesis of ibuprofen and naproxen, nonsteroidal antiinflammatory agents

Takayuki Shioiri; Nobutaka Kawai

doi:10.1021/jo00408a049

New methods and reagents in organic synthesis. 2. A facile conversion of alkyl aryl ketones to .alpha.-arylalkanoic acids using diphenyl phosphorazidate. Its application to a new synthesis of ibuprofen and naproxen, nonsteroidal antiinflammatory agents

The Journal of Organic Chemistry ◽

10.1021/jo00408a049 ◽

1978 ◽

Vol 43 (14) ◽

pp. 2936-2938 ◽

Cited By ~ 26

Author(s):

Takayuki Shioiri ◽

Nobutaka Kawai

Keyword(s):

Organic Synthesis ◽

Alkyl Aryl ◽

Antiinflammatory Agents ◽

New Methods ◽

New Synthesis ◽

Aryl Ketones ◽

Nonsteroidal Antiinflammatory Agents

Download Full-text

ChemInform Abstract: NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. PART 2. A FACILE CONVERSION OF ALKYL ARYL KETONES TO α-ARYLALKANOIC ACID USING DIPHENYL PHOSPHORAZIDATE. ITS APPLICATION TO A NEW SYNTHESIS OF IBUPROFEN AND NAPROXEN, NONSTEROIDAL ANTIINF

Chemischer Informationsdienst ◽

10.1002/chin.197902152 ◽

1979 ◽

Vol 10 (2) ◽

Author(s):

T. SHIOIRI ◽

N. KAWAI

Keyword(s):

Organic Synthesis ◽

Alkyl Aryl ◽

New Methods ◽

New Synthesis ◽

Aryl Ketones

Download Full-text

ChemInform Abstract: New Methods and Reagents in Organic Synthesis. Part 45. A New Synthesis of Some Non-Steroidal Antiinflammatory Agents via Cyanophosphates.

Chemischer Informationsdienst ◽

10.1002/chin.198642154 ◽

1986 ◽

Vol 17 (42) ◽

Author(s):

S. HARUSAWA ◽

S. NAKAMURA ◽

S. YAGI ◽

T. KURIHARA ◽

Y. HAMADA ◽

...

Keyword(s):

Organic Synthesis ◽

Antiinflammatory Agents ◽

New Methods ◽

New Synthesis

Download Full-text

ChemInform Abstract: NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. 35. A NEW SYNTHESIS OF SOME NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH THE 2-ARYLPROPIONIC ACID SKELETON BY THE USE OF DIPHENYL PHOSPHORAZIDATE (DPPA) AS A 1,3-DIPOLE

Chemischer Informationsdienst ◽

10.1002/chin.198410109 ◽

1984 ◽

Vol 15 (10) ◽

Author(s):

N. KAWAI ◽

N. KATO ◽

Y. HAMADA ◽

T. SHIOIRI

Keyword(s):

Organic Synthesis ◽

Antiinflammatory Agents ◽

New Methods ◽

New Synthesis ◽

Arylpropionic Acid

Download Full-text

ChemInform Abstract: New Methods and Reagents in Organic Synthesis. Part 69. A New Synthesis of α-Amino Acid and Peptide Amides of Aromatic Amines Using a Modified Curtius Reaction with Diphenyl Phosphorazidate.

ChemInform ◽

10.1002/chin.198803315 ◽

1988 ◽

Vol 19 (3) ◽

Author(s):

T. SHIOIRI ◽

M. MURATA ◽

Y. HAMADA

Keyword(s):

Amino Acid ◽

Organic Synthesis ◽

Aromatic Amines ◽

New Methods ◽

New Synthesis ◽

Curtius Reaction

Download Full-text

New methods and reagents in organic synthesis. 43. A new synthesis of tert-butyl peroxycarboxylates using diethyl phosphorocyanidate (DEPC).

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.32.3683 ◽

1984 ◽

Vol 32 (9) ◽

pp. 3683-3685 ◽

Cited By ~ 10

Author(s):

YASUMASA HAMADA ◽

AKIRA MIZUNO ◽

TOMOYASU OHNO ◽

TAKAYUKI SHIOIRI

Keyword(s):

Organic Synthesis ◽

Tert Butyl ◽

New Methods ◽

New Synthesis

Download Full-text

Condensation of 2-Aryl-1,3-dioxolanes with Alkyllithium Reagents. A New Synthesis of Alkyl Aryl Ketones from Aromatic Aldehydes1

The Journal of Organic Chemistry ◽

10.1021/jo01012a051 ◽

1965 ◽

Vol 30 (1) ◽

pp. 226-228 ◽

Cited By ~ 26

Author(s):

K. Darrell Berlin ◽

Brijraj S. Rathore ◽

Melbert Peterson

Keyword(s):

Alkyl Aryl ◽

New Synthesis ◽

Aryl Ketones

Download Full-text

ChemInform Abstract: NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. 43. A NEW SYNTHESIS OF TERT-BUTYL PEROXYCARBOXYLATES USING DIETHYL PHOSPHOROCYANIDATE (DEPC)

Chemischer Informationsdienst ◽

10.1002/chin.198511169 ◽

1985 ◽

Vol 16 (11) ◽

Author(s):

Y. HAMADA ◽

A. MIZUNO ◽

T. OHNO ◽

T. SHIOIRI

Keyword(s):

Organic Synthesis ◽

Tert Butyl ◽

New Methods ◽

New Synthesis

Download Full-text

ChemInform Abstract: A New Synthesis of 4-Methoxycarbonyloxazoles Using Diethyl Phosphorocyanidate (DEPC) and Its Application to the Synthesis of 3-Amino-4-hydroxytetrones. New Methods and Reagents in Organic Synthesis. Part 21.

Chemischer Informationsdienst ◽

10.1002/chin.198233189 ◽

1982 ◽

Vol 13 (33) ◽

Author(s):

Y. HAMADA ◽

S. MORITA ◽

T. SHIOIRI

Keyword(s):

Organic Synthesis ◽

New Methods ◽

New Synthesis

Download Full-text

New methods and reagents in organic synthesis, 24. A new synthesis of prumycin as an application of the direct c-acylation using diphenyl phosphorazidate (DPPA)

Tetrahedron Letters ◽

10.1016/s0040-4039(00)87057-4 ◽

1982 ◽

Vol 23 (11) ◽

pp. 1193-1196 ◽

Cited By ~ 28

Author(s):

Yasumasa Hamada ◽

Takayuki Shiori

Keyword(s):

Organic Synthesis ◽

New Methods ◽

New Synthesis

Download Full-text

New methods and reagents in organic synthesis. 35. A new synthesis of some non-steroidal anti-inflammatory agents with the 2-arylpropionic acid skeleton by the use of diphenyl phosphorazidate (DPPA) as a 1,3-dipole.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.31.3139 ◽

1983 ◽

Vol 31 (9) ◽

pp. 3139-3148 ◽

Cited By ~ 9

Author(s):

NOBUTAKA KAWAI ◽

NOBUHARU KATO ◽

YASUMASA HAMADA ◽

TAKAYUKI SHIOIRI

Keyword(s):

Organic Synthesis ◽

New Methods ◽

New Synthesis ◽

Arylpropionic Acid ◽

Anti Inflammatory

Download Full-text