Approaches to the synthesis of ring C transposed progesterone analogs: rac-7.beta.,15.alpha.-ethano-11,12-seco-11,19-bisnor-17.alpha.-pregn-4-ene-3,20-dione and rac-4,4-dimethyl-7,7-(ethylenedioxy)-4a.alpha.,4b.beta.,8a.alpha.,10a.beta.-perhydro-3-phenanthrenone

1987 ◽  
Vol 52 (11) ◽  
pp. 2263-2273 ◽  
Author(s):  
Mark J. Suto ◽  
Kenneth M. Tramposch ◽  
Mark Wierzba ◽  
Alan J. Solo ◽  
William Duax
Keyword(s):  
Progesterone Analogs

scholarly journals Progesterone Analogs Influence Germination of Clostridium sordellii and Clostridium difficile Spores In Vitro

2011 ◽  
Vol 193 (11) ◽  
pp. 2776-2783 ◽  
Author(s):  
M. Liggins ◽  
N. Ramirez ◽  
N. Magnuson ◽  
E. Abel-Santos
Keyword(s):  
Clostridium Difficile ◽  
Clostridium Sordellii ◽  
Progesterone Analogs

scholarly journals Bifunctional Gonadotropin-Releasing Hormone Antagonist-Progesterone Analogs with Increased Efficacy and Duration of Action

Endocrinology ◽  
2006 ◽  
Vol 147 (1) ◽  
pp. 571-579 ◽  
Author(s):  
Karen E. Ratcliffe ◽  
Hamish M. Fraser ◽  
Robin Sellar ◽  
Jean Rivier ◽  
Robert P. Millar
Keyword(s):  
Gonadotropin Releasing Hormone ◽  
Duration Of Action ◽  
Releasing Hormone ◽  
Progesterone Analogs

Steroids. CXXXI.1A New Series of 6-Substituted Progesterone Analogs

1960 ◽  
Vol 82 (9) ◽  
pp. 2304-2308 ◽  
Author(s):  
John A. Zderic ◽  
Dinorah Chavez Limon
Keyword(s):  
Progesterone Analogs

GLUCOCORTICOID ACTIVITY OF VARIOUS PROGESTERONE ANALOGS: CORRELATION BETWEEN SPECIFIC BINDING IN THYMUS AND LIVER AND BIOLOGIC ACTIVITY

1977 ◽  
Vol 286 (1 Biochemical A) ◽  
pp. 355-368 ◽  
Author(s):  
Dennis DiSorbo ◽  
Fred Rosen ◽  
Richard P. McPartland ◽  
Richard J. Milholland
Keyword(s):  
Specific Binding ◽  
Biologic Activity ◽  
Progesterone Analogs

14.alpha.,17.alpha.-Alkylidenedioxy steroids. 2. 19-Nor-9.alpha.,10.beta.- and 19-nor-9.beta.,10.alpha.-progesterone analogs

1973 ◽  
Vol 16 (11) ◽  
pp. 1302-1305 ◽  
Author(s):  
Arthur F. Marx ◽  
Herman J. Kooreman ◽  
Kapil D. Jaitly ◽  
Dirk Van der Sijde
Keyword(s):  
Progesterone Analogs

scholarly journals Management of Cancer Cachexia: ASCO Guideline

2020 ◽  
Vol 38 (21) ◽  
pp. 2438-2453 ◽  
Author(s):  
Eric J. Roeland ◽  
Kari Bohlke ◽  
Vickie E. Baracos ◽  
Eduardo Bruera ◽  
Egidio del Fabbro ◽  
...  
Keyword(s):  
Body Weight ◽  
Advanced Cancer ◽  
Systematic Reviews ◽  
Cancer Cachexia ◽  
Drop Out ◽  
Cochrane Library ◽  
Pharmacological Intervention ◽  
Dietary Counseling ◽  
Oral Nutritional Supplements ◽  
Progesterone Analogs

PURPOSE To provide evidence-based guidance on the clinical management of cancer cachexia in adult patients with advanced cancer. METHODS A systematic review of the literature collected evidence regarding nutritional, pharmacologic, and other interventions, such as exercise, for cancer cachexia. PubMed and the Cochrane Library were searched for randomized controlled trials (RCTs) and systematic reviews of RCTs published from 1966 through October 17, 2019. ASCO convened an Expert Panel to review the evidence and formulate recommendations. RESULTS The review included 20 systematic reviews and 13 additional RCTs. Dietary counseling, with or without oral nutritional supplements, was reported to increase body weight in some trials, but evidence remains limited. Pharmacologic interventions associated with improvements in appetite and/or body weight include progesterone analogs and corticosteroids. The other evaluated interventions either had no benefit or insufficient evidence of benefit to draw conclusions on efficacy. Limitations of the evidence include high drop-out rates, consistent with advanced cancer, as well as variability across studies in outcomes of interest and methods for outcome assessment. RECOMMENDATIONS Dietary counseling may be offered with the goals of providing patients and caregivers with advice for the management of cachexia. Enteral feeding tubes and parenteral nutrition should not be used routinely. In the absence of more robust evidence, no specific pharmacological intervention can be recommended as the standard of care; therefore, clinicians may choose not to prescribe medications specifically for the treatment of cancer cachexia. Nonetheless, when it is decided to trial a drug to improve appetite and/or improve weight gain, currently available pharmacologic interventions that may be used include progesterone analogs and short-term (weeks) corticosteroids.

scholarly journals Dizygotic pregnancy as a possible mechanism of fetal gestation with a biallel mutation in the CYP11A1 gene: clinical case description

2020 ◽  
Vol 66 (4) ◽  
pp. 45-49
Author(s):  
Natalia Yu. Kalinchenko ◽  
Yulia V. Kasyanova ◽  
Anatoly N. Tiulpakov
Keyword(s):  
Sex Steroids ◽  
Twin Pregnancy ◽  
Autosomal Recessive ◽  
Autosomal Recessive Disease ◽  
Hypergonadotropic Hypogonadism ◽  
Rare Form ◽  
Primary Adrenal Insufficiency ◽  
Hormonal Function ◽  
Progesterone Analogs ◽  
Rare Autosomal Recessive Disease

One of the variants of congenital dysfunction of the adrenal cortex is a deficiency of the enzyme P450scc, which catalyzes the first stage of steroidogenesis. This is a rare autosomal recessive disease, the classic manifestation of which is primary adrenal insufficiency with a deficiency of gluco-and mineralocorticoids and a violation of the synthesis of sex steroids, which usually leads to a complete lack of masculinization in patients with karyotype 46, XY and hypergonadotropic hypogonadism in both sexes. Previously, it was suggested That p450scc deficiency is incompatible with the normal course of pregnancy, since the enzyme is expressed in the placenta, where it is necessary for the synthesis of progesterone, the main pregnancy hormone, and, consequently, the birth of a child with A p450scc deficiency is impossible. However, the literature describes clinical cases of p450scc deficiency with partially preserved enzyme function, which explains the normal course of pregnancy. Whereas cases of confirmed p450scc deficiency with zero enzyme activity are unique, not being explained until now. We present a description of severe p450scc deficiency in a child born from a dizygotic twin pregnancy in which the second Sib was healthy. It is possible that the preserved hormonal function of the second placenta and (or) treatment with progesterone analogs during gestation contributed to gestation in this rare form of steroidogenesis disorder.

scholarly journals Oral Allylestrenol: A Pregnancy-supporting Progestogen

2017 ◽  
Vol 9 (4) ◽  
pp. 297-303
Author(s):  
Narendra Malhotra ◽  
Ruchika Garg
Keyword(s):  
Side Effects ◽  
Intrauterine Growth Restriction ◽  
Preterm Labor ◽  
Gestational Hypertension ◽  
Oral Activity ◽  
Threatened Preterm Labor ◽  
Progesterone Analogs ◽  
Synthetic Progestogen ◽  
Unique Mechanism ◽  
Natural Progesterone

ABSTRACT Allylestrenol is a synthetic progestogen that has been in therapeutic use in the management of mild to severe cases of certain obstetric complications, like selected forms of miscarriage/abortion, threatened preterm labor, intrauterine growth restriction (IUGR), and gestational hypertension. Natural progesterone may be used for treatment; however, it has the property of being rapidly metabolized in the liver besides having little or no oral activity. While there are many other synthetic and orally administrable progesterone analogs in the market, most of them, which are 19-nortestosterone derivatives, possess various undesirable side effects like symptoms of intolerance and a tendency to virilization. Allylestrenol, despite being a 19-nortestosterone derivative, has no known side effects including those attributed to the other members of its class, which is theorized to be due to subtle differences in its chemical structure, giving it a unique mechanism of action consisting of a triple effect—trophoblastic, placentotropic, and β2-adrenergic. The present review is mainly aimed at understanding the whys and wherefores behind the molecule's moderate efficacy and remarkable safety along with examining the data from various studies. How to cite this article Malhotra N, Garg R, Malhotra N, Malhotra J. Oral Allylestrenol: A Pregnancy-supporting Progestogen. J South Asian Feder Obst Gynae 2017;9(4):297-303.

ChemInform Abstract: 14ALPHA,17ALPHA-ALKYLIDENEDIOXY STEROIDS PART 2, 19-NOR-9ALPHA,10BETA- AND 19-NOR-9BETA,10ALPHA-PROGESTERONE ANALOGS

1974 ◽  
Vol 5 (10) ◽  
pp. no-no
Author(s):  
A. F. MARX ◽  
H. J. KOOREMAN ◽  
K. D. JAITLY ◽  
D. VAN DER SIJDE
Keyword(s):  
Progesterone Analogs
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