Computer-assisted mechanistic evaluation of organic reactions. 12. pKa predictions for organic compounds in Me2SO

1986 ◽  
Vol 51 (18) ◽  
pp. 3513-3522 ◽  
Author(s):  
Alan J. Gushurst ◽  
William L. Jorgensen
Keyword(s):  
Organic Compounds ◽  
Organic Reactions ◽  
Computer Assisted

scholarly journals Non-Enzymatic Desymmetrization Reactions in Aqueous Media

Symmetry ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 720
Author(s):  
Satomi Niwayama
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Functional Groups ◽  
Organic Compounds ◽  
Recent Progress ◽  
Aqueous Media ◽  
Building Blocks ◽  
Organic Reactions ◽  
Environmentally Benign ◽  
Enzymatic Desymmetrization

Symmetric organic compounds are generally obtained inexpensively, and therefore they can be attractive building blocks for the total synthesis of various pharmaceuticals and natural products. The drawback is that discriminating the identical functional groups in the symmetric compounds is difficult. Water is the most environmentally benign and inexpensive solvent. However, successful organic reactions in water are rather limited due to the hydrophobicity of organic compounds in general. Therefore, desymmetrization reactions in aqueous media are expected to offer versatile strategies for the synthesis of a variety of significant organic compounds. This review focuses on the recent progress of desymmetrization reactions of symmetric organic compounds in aqueous media without utilizing enzymes.

scholarly journals Computer-assisted structural analysis of organic compounds from 13C-NMR spectra.

1994 ◽  
Vol 43 (7) ◽  
pp. 517-524
Author(s):  
Keiji SAITO ◽  
Yoshiaki ISHIDA ◽  
Tokio OOSHIMA
Keyword(s):  
Structural Analysis ◽  
Organic Compounds ◽  
13C Nmr ◽  
Nmr Spectra ◽  
Computer Assisted ◽  
13C Nmr Spectra

Tin-Mediated Radical Cyclization Reactions

2021 ◽  
Vol 25 ◽  
Author(s):  
Saima malik ◽  
Aditya G. Lavekar ◽  
Bimal Krishna Banik
Keyword(s):  
Organic Compounds ◽  
Organic Synthesis ◽  
Biological Significance ◽  
Radical Cyclization ◽  
Organic Reactions ◽  
Cyclization Reactions ◽  
Complex Molecules ◽  
Radical Chemistry ◽  
Wide Range

: The radical was first come into existence in 1900 by Gomberg, where the triphenylmethane radical was explored. Thus, even to date, two centuries have seen radical chemistry as the methodology of preference in organic synthesis. Due to the fascinating nature of the radical-mediated cyclization reactions, it always caught the eye of organic chemists for the synthesis of novel organic compounds with diverse stereochemistry. Moreover, the development of radical methods further proves beneficial for the synthesis by providing atom- and step-economical methods to complex molecules. Among these, where radical chemistry has been employed, the use of tin-based radical annulation is the most common and widely used field for the synthesis of a wide range of organic reactions with medicinal importance. In this review, we compiled recent tin-mediated radical cyclization reactions toward the synthesis of molecules of biological significance.

Computer-assisted mechanistic evaluation of organic reactions. 18. Reductions with hydrides

1991 ◽  
Vol 56 (15) ◽  
pp. 4718-4733 ◽  
Author(s):  
Genevieve D. Paderes ◽  
Pascal Metivier ◽  
William L. Jorgensen
Keyword(s):  
Organic Reactions ◽  
Computer Assisted
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