N-(9-phenylfluoren-9-yl)-.alpha.-amino ketones and N-(9-phenylfluoren-9-yl)-.alpha.-amino aldehydes as chiral educts for the synthesis of optically pure 4-alkyl-3-hydroxy-2-amino acids. Synthesis of the C-9 amino acid MeBmt present in cyclosporin

1990 ◽  
Vol 55 (11) ◽  
pp. 3511-3522 ◽  
Author(s):  
William D. Lubell ◽  
Timothy F. Jamison ◽  
Henry Rapoport
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Amino Aldehydes ◽  
Optically Pure

ChemInform Abstract: Versatile Synthons for Optically Pure α-Amino Aldehydes and α-Amino Acids: (+)- and (-)-4,5-Dialkoxy-2-oxazolidinones (V) and (XVI).

ChemInform ◽  
2010 ◽  
Vol 32 (30) ◽  
pp. no-no
Author(s):  
Toru Morita ◽  
Yusuke Nagasawa ◽  
Syunsuke Yahiro ◽  
Hirofumi Matsunaga ◽  
Takehisa Kunieda
Keyword(s):  
Amino Acids ◽  
Amino Aldehydes ◽  
Optically Pure

Versatile Synthons for Optically Pure α-Amino Aldehydes and α-Amino Acids: (+)- and (−)-4,5-Dialkoxy-2-oxazolidinones

2001 ◽  
Vol 3 (6) ◽  
pp. 897-899 ◽  
Author(s):  
Toru Morita ◽  
Yusuke Nagasawa ◽  
Syunsuke Yahiro ◽  
Hirofumi Matsunaga ◽  
Takehisa Kunieda
Keyword(s):  
Amino Acids ◽  
Amino Aldehydes ◽  
Optically Pure

Amidohydrolase Process: Expanding the use of l-N-carbamoylase/N-succinyl-amino acid racemase tandem for the production of different optically pure l-amino acids

2014 ◽  
Vol 49 (8) ◽  
pp. 1281-1287 ◽  
Author(s):  
Pablo Soriano-Maldonado ◽  
María José Rodríguez-Alonso ◽  
Carmen Hernández-Cervantes ◽  
Ignacio Rodríguez-García ◽  
Josefa María Clemente-Jiménez ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Optically Pure ◽  
Amino Acid Racemase

In vitro evolution of an l-amino acid deaminase active on l-1-naphthylalanine

2018 ◽  
Vol 8 (20) ◽  
pp. 5359-5367 ◽  
Author(s):  
Roberta Melis ◽  
Elena Rosini ◽  
Valentina Pirillo ◽  
Loredano Pollegioni ◽  
Gianluca Molla
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
In Vitro Evolution ◽  
Keto Acids ◽  
Optically Pure ◽  
Enantioselective Biocatalysis

l-Amino acid deaminase from Proteus myxofaciens (PmaLAAD) is a promising biocatalyst for enantioselective biocatalysis that can be exploited to produce optically pure d-amino acids or α-keto acids.

Dietary intake of tryptophan tied emotion-related impulsivity in humans

2019 ◽  
pp. 1-8 ◽  
Author(s):  
Florian Javelle ◽  
Descartes Li ◽  
Philipp Zimmer ◽  
Sheri L. Johnson
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Food Intake ◽  
Essential Amino Acid ◽  
Food Habits ◽  
Psychological Disorder ◽  
Serotonin Synthesis ◽  
Amino Acid Tryptophan ◽  
Pass Through ◽  
Three Factor

Abstract. Emotion-related impulsivity, defined as the tendency to say or do things that one later regret during periods of heightened emotion, has been tied to a broad range of psychopathologies. Previous work has suggested that emotion-related impulsivity is tied to an impaired function of the serotonergic system. Central serotonin synthesis relies on the intake of the essential amino acid, tryptophan and its ability to pass through the blood brain barrier. Objective: The aim of this study was to determine the association between emotion-related impulsivity and tryptophan intake. Methods: Undergraduate participants (N = 25, 16 women, 9 men) completed a self-rated measure of impulsivity (Three Factor Impulsivity Index, TFI) and daily logs of their food intake and exercise. These data were coded using the software NutriNote to evaluate intakes of tryptophan, large neutral amino acids, vitamins B6/B12, and exercise. Results: Correlational analyses indicated that higher tryptophan intake was associated with significantly lower scores on two out of three subscales of the TFI, Pervasive Influence of Feelings scores r =  –.502, p < . 010, and (lack-of) Follow-Through scores, r =  –.407, p < . 050. Conclusion: Findings provide further evidence that emotion-related impulsivity is correlated to serotonergic indices, even when considering only food habits. It also suggests the need for more research on whether tryptophan supplements might be beneficial for impulsive persons suffering from a psychological disorder.

Purification of Antihemophilic Factor (Factor VIII) by Amino Acid Precipitation*

1964 ◽  
Vol 11 (01) ◽  
pp. 064-074 ◽  
Author(s):  
Robert H Wagner ◽  
William D McLester ◽  
Marion Smith ◽  
K. M Brinkhous
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Factor Viii ◽  
Plasma Protein ◽  
Acid Precipitation ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Specific Procedure ◽  
Beta Alanine ◽  
Antihemophilic Factor

Summary1. The use of several amino acids, glycine, alpha-aminobutyric acid, alanine, beta-alanine, and gamma-aminobutyric acid, as plasma protein precipitants is described.2. A specific procedure is detailed for the preparation of canine antihemophilic factor (AHF, Factor VIII) in which glycine, beta-alanine, and gammaaminobutyric acid serve as the protein precipitants.3. Preliminary results are reported for the precipitation of bovine and human AHF with amino acids.

Complete Covalent Structure of Human Platelet Factor 4

1979 ◽  
Vol 42 (05) ◽  
pp. 1652-1660 ◽  
Author(s):  
Francis J Morgan ◽  
Geoffrey S Begg ◽  
Colin N Chesterman
Keyword(s):  
Amino Acids ◽  
Molecular Weight ◽  
Amino Acid ◽  
Amino Acid Sequence ◽  
Human Platelet ◽  
Platelet Factor 4 ◽  
Platelet Factor ◽  
Disulphide Bonds ◽  
Covalent Structure

SummaryThe amino acid sequence of the subunit of human platelet factor 4 has been determined. Human platelet factor 4 consists of identical subunits containing 70 amino acids, each with a molecular weight of 7,756. The molecule contains no methionine, phenylalanine or tryptophan. The proposed amino acid sequence of PF4 is: Glu-Ala-Glu-Glu-Asp-Gly-Asp-Leu-Gln-Cys-Leu-Cys-Val-Lys-Thr-Thr-Ser- Gln-Val-Arg-Pro-Arg-His-Ile-Thr-Ser-Leu-Glu-Val-Ile-Lys-Ala-Gly-Pro-His-Cys-Pro-Thr-Ala-Gin- Leu-Ile-Ala-Thr-Leu-Lys-Asn-Gly-Arg-Lys-Ile-Cys-Leu-Asp-Leu-Gln-Ala-Pro-Leu-Tyr-Lys-Lys- Ile-Ile-Lys-Lys-Leu-Leu-Glu-Ser. From consideration of the homology with p-thromboglobulin, disulphide bonds between residues 10 and 36 and between residues 12 and 52 can be inferred.

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