Model studies probing the amino-Claisen rearrangement approach to hydroisoquinoline synthesis. Development of methods for stereocontrolled introduction of reserpine E ring type functionality

1989 ◽  
Vol 54 (12) ◽  
pp. 2893-2904 ◽  
Author(s):  
Ellen W. Baxter ◽  
David Labaree ◽  
Shouchung Chao ◽  
Patrick S. Mariano
Keyword(s):  
Claisen Rearrangement ◽  
Ring Type ◽  
Model Studies

Experiments directed towards the synthesis of anthracyclinones. VII. Model studies with allyl naphthalenyl ethers

1983 ◽  
Vol 36 (4) ◽  
pp. 803 ◽  
Author(s):  
IK Boddy ◽  
RC Cambie ◽  
G Dixon ◽  
PS Rutledge ◽  
PD Woodgate
Keyword(s):  
Claisen Rearrangement ◽  
Side Chain ◽  
Model Studies ◽  
Chain Isomerization

The Claisen rearrangement of some allyl naphthalen-1-yl ethers has been examined, together with methods for modification of the resulting 2-ally1 side chain. Isomerization of the C-allyl substituent to a prop-1-enyl group followed by ozonolysis gives a formyl derivative, while ozonolysis of a 2-(2-methylprop-2-enyl) moiety or mercuriation of a 2-(2-chloroprop-2-enyl) substituent leads to an acetonyl derivative. Treatment of phenols with iodine(I) acetate and an excess of silver(I) acetate gives 4-hydroxyaryl acetates, probably via dienone intermediates.

Model studies for the stereoselective construction of the BC-ring of armatol F based on Ireland-Claisen rearrangement and relay ring-closing olefin metathesis

2010 ◽  
Vol 51 (34) ◽  
pp. 4543-4546 ◽  
Author(s):  
Kenshu Fujiwara ◽  
Keita Tanaka ◽  
Yasushi Katagiri ◽  
Hidetoshi Kawai ◽  
Takanori Suzuki
Keyword(s):  
Olefin Metathesis ◽  
Claisen Rearrangement ◽  
Model Studies

scholarly journals Synthesis of the B-seco limonoid core scaffold

2014 ◽  
Vol 10 ◽  
pp. 194-208 ◽  
Author(s):  
Hanna Bruss ◽  
Hannah Schuster ◽  
Rémi Martinez ◽  
Markus Kaiser ◽  
Andrey P Antonchick ◽  
...  
Keyword(s):  
Natural Products ◽  
Claisen Rearrangement ◽  
Sigmatropic Rearrangement ◽  
Detailed Model ◽  
Model Studies ◽  
Sterically Demanding

Synthetic investigations towards the structurally complex and highly decorated framework of B-seco limonoid natural products by means of a [3,3]-sigmatropic rearrangement are described. Detailed model studies reveal, that an Ireland–Claisen rearrangement can be employed to construct the central C9–C10 bond thereby giving access to the B-seco limonoid scaffold. However, application of the developed strategy ended up failing in more complex and sterically demanding systems.

“In vitro” and in Animal Model Studies on a Double Virus- Inactivated Factor VIII Concentrate

1995 ◽  
Vol 74 (03) ◽  
pp. 868-873 ◽  
Author(s):  
Silvana Arrighi ◽  
Roberta Rossi ◽  
Maria Giuseppina Borri ◽  
Vladimir Lesnikov ◽  
Marina Lesnikov ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Animal Model ◽  
Factor Viii ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Virus Inactivation ◽  
Enveloped Viruses ◽  
Model Studies ◽  
Heat Treated

SummaryTo improve the safety of plasma derived factor VIII (FVIII) concentrate, we introduced a final super heat treatment (100° C for 30 min) as additional virus inactivation step applied to a lyophilized, highly purified FVIII concentrate (100 IU/mg of proteins) already virus inactivated using the solvent/detergent (SID) method during the manufacturing process.The efficiency of the super heat treatment was demonstrated in inactivating two non-lipid enveloped viruses (Hepatitis A virus and Poliovirus 1). The loss of FVIII procoagulant activity during the super heat treatment was of about 15%, estimated both by clotting and chromogenic assays. No substantial changes were observed in physical, biochemical and immunological characteristics of the heat treated FVIII concentrate in comparison with those of the FVIII before heat treatment.

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