Synthetic methods and reactions. 135. Single-step reductive isomerization of unsaturated polycyclics to C4n+6H4n+12 diamondoid cage hydrocarbons with sodium borohydride/triflic acid

1989 ◽  
Vol 54 (6) ◽  
pp. 1450-1451 ◽  
Author(s):  
George A. Olah ◽  
An Hsiang Wu ◽  
Omar Farooq ◽  
G. K. Surya Prakash
Keyword(s):  
Sodium Borohydride ◽  
Single Step ◽  
Synthetic Methods ◽  
Triflic Acid

scholarly journals Palladium-Catalysed Synthesis and Transformation of Quinolones

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 228 ◽  
Author(s):  
Vera L. M. Silva ◽  
Artur M. S. Silva
Keyword(s):  
Multiple Bond ◽  
Single Step ◽  
Molecular Structures ◽  
Synthetic Methods ◽  
Complex Molecules ◽  
Bond Forming ◽  
Drug Candidates ◽  
Rapid Construction ◽  
Wide Range ◽  
Privileged Structures

Palladium-catalysed reactions have had a large impact on synthetic organic chemistry and have found many applications in target-oriented synthesis. Their widespread use in organic synthesis is due to the mild conditions associated with the reactions together with their tolerance of a wide range of functional groups. Moreover, these types of reactions allow the rapid construction of complex molecules through multiple bond-forming reactions in a single step, the so-called tandem processes. Pd-catalysed reactions have been applied to the synthesis of a large number of natural products and bioactive compounds, some of them of complex molecular structures. This review article aims to present an overview of the most important Pd-catalysed reactions employed in the synthesis and transformations of quinolin-2(1H)-ones and quinolin-4(1H)-ones. These compounds are widely recognized by their diverse bioactivity, being privileged structures in medicinal chemistry and useful structural moieties for the development of new drug candidates. Furthermore, they hold significant interest due to their host–guest chemistry; applications in chemical, biochemical and environmental analyses and use in the development of new synthetic methods. In some cases, the quinolone formation step cannot be ascribed to a claimed Pd-catalysed reaction but this reaction is crucial to get the appropriate substrate for cyclization into the quinolone. Herein we present and discuss different economical, efficient and selective synthetic strategies to access quinolone-type compounds.

Synthetic methods and reactions. 188. Triflic acid catalyzed phenylamination of aromatics with phenyl azide

1993 ◽  
Vol 58 (24) ◽  
pp. 6900-6901 ◽  
Author(s):  
George A. Olah ◽  
Pichika Ramaiah ◽  
Qi Wang ◽  
G. K. Surya Prakash
Keyword(s):  
Synthetic Methods ◽  
Triflic Acid ◽  
Phenyl Azide ◽  
Acid Catalyzed

Reagents and synthetic methods. 31. Silylations with N-trimethylsilyl-2-oxazolidinone (TMSO)

1984 ◽  
Vol 62 (2) ◽  
pp. 336-340 ◽  
Author(s):  
Jesús M. Aizpurua ◽  
Claudio Palomo ◽  
Antonio L. Palomo
Keyword(s):  
Carboxylic Acids ◽  
Synthetic Methods ◽  
Triflic Acid ◽  
Points Of View

Silylation of ketones, alcohols, mercaptans, and carboxylic acids with N-trimethylsilyl-2-oxazolidinone (TMSO) and triflic acid as catalyst has been described from synthetic and mechanistic points of view.

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