Synthesis and carbon-13 NMR of an unusual tricyclic barbituric acid derivative

1984 ◽  
Vol 49 (17) ◽  
pp. 3227-3230 ◽  
Author(s):  
Wayne J. Brouillette ◽  
Joyce D. Friedrich ◽  
Donald D. Muccio
Keyword(s):  
Acid Derivative ◽  
Barbituric Acid ◽  
Barbituric Acid Derivative

Hydrogen Bonding Self‐Assembly of Functionalized [60]Fullerene with a Barbituric Acid Derivative

2005 ◽  
Vol 13 (3) ◽  
pp. 193-202
Author(s):  
Jun‐Ping Zhang ◽  
Nai‐Xing Wang ◽  
Yun‐Xu Yang ◽  
An‐Guang Yu ◽  
Wu‐Wei Wang ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Acid Derivative ◽  
Self Assembly ◽  
Barbituric Acid ◽  
Barbituric Acid Derivative

A new dibenzothiophene-based dual-channel chemosensor for cyanide with aggregation induced emission

2019 ◽  
Vol 11 (43) ◽  
pp. 5553-5561 ◽  
Author(s):  
Qiqi Zou ◽  
Furong Tao ◽  
Zhen Xu ◽  
Yunqiao Ding ◽  
Yan Tian ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Acid Derivative ◽  
Barbituric Acid ◽  
Aggregation Induced Emission ◽  
Naked Eye ◽  
Dual Channel ◽  
Barbituric Acid Derivative

A new dibenzothiophene-based barbituric acid derivative (DTB) with an aggregation induced emission (AIE) effect was synthesized as a naked-eye colorimetric and fluorescent probe for CN−.

scholarly journals Treatment with a New Barbituric Acid Derivative Exerts Antiproliferative and Antimigratory Effects against Sorafenib Resistance in Hepatocellular Carcinoma

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2856
Author(s):  
Yi-Jen Liao ◽  
Shih-Ming Hsu ◽  
Chia-Ying Chien ◽  
Yuan-Hsi Wang ◽  
Ming-Hua Hsu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Acid Derivative ◽  
Cancer Cell ◽  
Barbituric Acid ◽  
Dependent Manner ◽  
Mesenchymal Transition ◽  
Barbituric Acid Derivative ◽  
Barbituric Acid Derivatives ◽  
Hcc Cells

Hepatocellular carcinoma (HCC) is a common cause of cancer death worldwide. Sorafenib, a multikinase inhibitor, is the first-line drug approved by the Food and Drug Administration (FDA) for the treatment of patients with advanced HCC. However, most patients who continuously receive sorafenib may acquire resistance to this drug. Therefore, it is important to develop a new compound to treat liver cancer and sorafenib-resistant liver cancer. Barbituric acid derivatives have been used as antiasthmatic drugs in the clinic. We previously reported that a novel barbituric acid derivative inhibited carbon tetrachloride-induced liver fibrosis in mice, but its effects on liver cancer remain unknown. Thus, the purpose of this study was to investigate the antitumor effect of barbituric acid derivatives on HCC cells and sorafenib-resistant HCC cells (HCC-SRs). Our findings reveal that one of the barbituric acid derivatives, BA-5, significantly inhibited HCC and HCC-SR cell viability in a dose- and time-dependent manner. Therefore, compound BA-5 was selected for further experiments. Western blot data revealed that BA-5 treatment decreased the phosphorylation of AKT/p70s6k without affecting the MAPK pathway and increased cleaved PARP and cleaved caspase-7 in both HCC and HCC-SR cells. Since epithelial-mesenchymal transition plays a significant role in regulating cancer invasion and migration, we used the wound healing assay to evaluate the antimigratory effect of compound BA-5. The results showed that BA-5 treatment inhibited HCC and HCC-SR cell migration and reduced Vimentin protein expression. These results were confirmed by microarray analysis showing that BA-5 treatment influenced cancer cell motility and growth-related pathways. In the xenograft mouse model experiment, BA-5 administration significantly inhibited HCC cancer cell growth in mice. Furthermore, the combination of BA-5 with a low dose of regorafenib synergistically inhibited HCC-SR cell proliferation. In conclusion, our study showed that the barbituric acid derivative BA-5 is a new candidate for HCC and sorafenib-resistant HCC therapy.

Actgrectation of light active barbituric acid derivative in Sollmon

1994 ◽  
Author(s):  
S.G. Chen ◽  
X.D. Chai ◽  
Y.W. Cao ◽  
W.S. Yang ◽  
X.Y. Tang ◽  
...  
Keyword(s):  
Acid Derivative ◽  
Barbituric Acid ◽  
Barbituric Acid Derivative
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