Activation of Pig Liver Esterase in Organic Media with Organic Polymers. Application to the Enantioselective Acylation of Racemic Functionalized Secondary Alcohols

2001 ◽  
Vol 66 (10) ◽  
pp. 3384-3396 ◽  
Author(s):  
Hans-Joachim Gais ◽  
Manfred Jungen ◽  
Vasudev Jadhav
Keyword(s):  
Organic Media ◽  
Secondary Alcohols ◽  
Organic Polymers ◽  
Pig Liver ◽  
Pig Liver Esterase ◽  
Liver Esterase ◽  
Enantioselective Acylation

Enantiospecific enzyme-catalysed resolution of novel N,N-disubstituted α-amino acid phenolic ester derivatives using pig liver esterase

2001 ◽  
pp. 362-365 ◽  
Author(s):  
D. Jonathan Bennett ◽  
Kirsteen I. Buchanan ◽  
Andrew Cooke ◽  
Ola Epemolu ◽  
Niall M. Hamilton ◽  
...  
Keyword(s):  
Amino Acid ◽  
Pig Liver ◽  
Pig Liver Esterase ◽  
Liver Esterase

Enzymes in organic synthesis. 33. Stereoselective pig liver esterase-catalyzed hydrolyses of meso cyclopentyl-, tetrahydrofuranyl-, and tetrahydrothiophenyl-1,3-diesters

1985 ◽  
Vol 63 (2) ◽  
pp. 452-456 ◽  
Author(s):  
J. Bryan Jones ◽  
R. Scott Hinks ◽  
Philip G. Hultin
Keyword(s):  
Organic Synthesis ◽  
Absolute Configuration ◽  
Enantiomeric Excess ◽  
Membered Ring ◽  
Pig Liver ◽  
Pig Liver Esterase ◽  
Preparative Scale ◽  
Liver Esterase ◽  
The Absolute ◽  
Enzymes In Organic Synthesis

Preparative-scale pig liver esterase-catalyzed hydrolyses of five-membered ring meso-1,3-diesters are enantiotopically selective. While pro-S enantiotopic selectivity is exhibited in each case, the absolute configuration sense of the hydrolysis in the cyclopentyl series is opposite to that of both the tetrahydrofuranyl and tetrahydrothiophenyl diesters. The enantiomeric excess levels induced are in the 34–46% range.

Enzyme-catalyzed asymmetric synthesis. 8. Enantioselectivity of pig liver esterase catalyzed hydrolyses of 4-substituted meso cyclopentane 1,2-diesters

1989 ◽  
Vol 54 (21) ◽  
pp. 5115-5122 ◽  
Author(s):  
Hans Joachim Gais ◽  
Gerd Buelow ◽  
Andrzej Zatorski ◽  
Mathias Jentsch ◽  
Peter Maidonis ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Pig Liver ◽  
Pig Liver Esterase ◽  
Liver Esterase
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