2-Deoxy-3-C-(hydroxymethyl)-D-pentofuranose Derivatives: Stereoselective Synthesis and Conversion into a Novel Class of Nucleoside Analogs

1995 ◽  
Vol 60 (22) ◽  
pp. 7298-7303 ◽  
Author(s):  
Claus Scheuer-Larsen ◽  
Henrik M. Pfundheller ◽  
Jesper Wengel
Keyword(s):  
Stereoselective Synthesis ◽  
Nucleoside Analogs

Purine and Pyrimidine Nucleoside Analogs of 3'-C-Methyladenosine as Antitumor Agents

2006 ◽  
Vol 71 (7) ◽  
pp. 1088-1098 ◽  
Author(s):  
Loredana Cappellacci ◽  
Palmarisa Franchetti ◽  
Riccardo Petrelli ◽  
Sara Riccioni ◽  
Patrizia Vita ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Stereoselective Synthesis ◽  
Antitumor Agents ◽  
Nucleoside Analogs ◽  
Myelogenous Leukemia ◽  
Human Leukemia ◽  
Ribonucleotide Reductase Inhibitor ◽  
Carcinoma Cell Lines ◽  
Antitumor Evaluation ◽  
Leukemia K562 Cell

3'-C-Methyladenosine (3'-Me-Ado) is a mechanism-based ribonucleotide reductase inhibitor endowed with antitumor activity against both human leukemia and carcinoma cell lines. In this paper, we report the synthesis and antitumor evaluation of a series of purine and pyrimidine 3'-C-methylribonucleoside analogs of 3'-Me-Ado. A stereoselective synthesis of the arabino analog of 3'-Me-Ado is also described. Among the tested compounds, only 3'-C-methyluridine showed moderate antitumor activity against human myelogenous leukemia K562 cell line.

Stereoselective synthesis of nicotinamide β-riboside and nucleoside analogs

2004 ◽  
Vol 14 (18) ◽  
pp. 4655-4658 ◽  
Author(s):  
Palmarisa Franchetti ◽  
Michela Pasqualini ◽  
Riccardo Petrelli ◽  
Massimo Ricciutelli ◽  
Patrizia Vita ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Nucleoside Analogs
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