Kinetics of the Isomerization of 1-Decene to cis- and trans-2-Decene

1995 ◽  
Vol 60 (13) ◽  
pp. 4255-4257 ◽  
Author(s):  
Mario L. Aimar ◽  
Rita H. de Rossi
Keyword(s):  
Cis And Trans ◽  
Kinetics Of

[1H,15N] N.M.R. Kinetic Studies of Reactions of cis- and trans-[PtCl2(15NH3)(c-C6H1115NH2)] with Guanosine 5'-Monophosphate

1999 ◽  
Vol 52 (3) ◽  
pp. 173 ◽  
Author(s):  
Sarah J. Barton ◽  
Kevin J. Barnham ◽  
Abraha Habtemariam ◽  
Urban Frey ◽  
Rodney E. Sue ◽  
...  
Keyword(s):  
Trans Isomer ◽  
Active Metabolite ◽  
Kinetic Studies ◽  
Trans Influence ◽  
Trans Complex ◽  
Kinetics Of Reaction ◽  
Cis And Trans ◽  
Kinetics Of ◽  
Cis Isomer ◽  
Amine Ligand

cis-[PtCl2(15NH3)(c-C6H11NH2)] is an active metabolite of the oral platinum(IV) anticancer drug cis,trans,cis-[PtCl2(CH3CO2)2(NH2)(c-C6H11NH2)]. Since it is likely that guanine bases on DNA are targets for this drug, we have analysed the kinetics of reaction of this platinum(II) metabolite with guanosine 5′-monophosphate (5′-GMP) at 310 K, pH 7, using [1H, 15N] n.m.r. methods. Reactions of the trans isomer are reported for comparison. The reactions proceed via aquated intermediates, and, for the cis isomer, the rates of aquation and substitution of H2O by 5′-GMP are 2-5 times faster trans to the amine ligand (c-C6H11NH2) compared to trans to NH3 for both the first and second steps. For the trans complex, the first aquation step is c. 3 times faster than for the cis complex, as expected from the higher trans influence of Cl¯, whereas the rate of the second aquation step (trans to N7 of 5′-GMP) is comparable to that trans to NH3. These findings have implications for the courses of reactions with DNA.

Kinetics of displacement of dimethyl sulfide from cis- and trans-dichlorobis(dimethyl sulfide)platinum(II) by heterocyclic amines in 1,2-dimethoxyethane

1981 ◽  
Vol 20 (12) ◽  
pp. 4166-4168 ◽  
Author(s):  
Luciano. Conovese ◽  
Lucio. Cattalini ◽  
Giampaolo. Marangoni ◽  
Gianni. Michelon ◽  
Martin L. Tobe
Keyword(s):  
Dimethyl Sulfide ◽  
Heterocyclic Amines ◽  
Cis And Trans ◽  
Kinetics Of
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