Intramolecular 1,4-Dipolar Cycloadditions of Cross-Conjugated Heteroaromatic Betaines. Synthesis of Hexahydrojulolidines and Related Peri- and Ortho-Fused Ring Systems

1995 ◽  
Vol 60 (12) ◽  
pp. 3795-3805 ◽  
Author(s):  
Kevin T. Potts ◽  
Thevarak Rochanapruk ◽  
Albert Padwa ◽  
Steven J. Coats ◽  
Lazaros Hadjiarapoglou
Keyword(s):  
Ring Systems ◽  
Dipolar Cycloadditions ◽  
Fused Ring

Use of highly stereospecific 1,3-dipolar cycloadditions of cyclic nitrones with acetylenes in the preparation of novel heterocyclic ring systems

1997 ◽  
pp. 155-162 ◽  
Author(s):  
W. Russell Bowman ◽  
Roy V. Davies ◽  
Alexandra M. Z. Slawin ◽  
Gian S. Sohal ◽  
Roger B. Titman ◽  
...  
Keyword(s):  
Heterocyclic Ring ◽  
Ring Systems ◽  
Dipolar Cycloadditions ◽  
Cyclic Nitrones

Synthesis of Pyrazolofuropyrazine via One-Pot SNAr Reaction and Intramolecular Direct C–H Arylation

Synthesis ◽  
2018 ◽  
Vol 50 (07) ◽  
pp. 1493-1498 ◽  
Author(s):  
Shinichiro Fuse ◽  
Hiroyuki Nakamura ◽  
Megumi Inaba ◽  
Shinichi Sato ◽  
Manjusha Joshi
Keyword(s):  
Drug Discovery ◽  
Rapid Development ◽  
Ring System ◽  
Biologically Active ◽  
Drug Candidate ◽  
One Pot ◽  
Ring Systems ◽  
Drug Candidates ◽  
Fused Ring ◽  
Snar Reaction

Fused-ring systems containing heterocycles are attractive templates for drug discovery. Biologically active 6-5-5+6 fused-ring systems that possess heterocycles are available, but these require a relatively large number of synthetic steps for preparation. Therefore, pyrazolofuropyrazine was designed as a 6-5-5+6 ring system template that incorporates ready accessibility for drug discovery. Pyrazolofuropyrazines were successfully constructed in only a few steps via one-pot SNAr reaction/intramolecular C–H direct arylation. As a drug candidate, pyrazolofuropyrazine has earned a favorable LogP, although significant biological activity has yet to be established; the ready accessibility of pyrazolofuropyrazine template, however, offers an opportunity for the rapid development of promising new drug candidates.

Synthesis of Fused Ring Systems with Ring Junction Heteroatoms

2010 ◽  
pp. 889-916
Author(s):  
Alan R. Katritzky ◽  
Christopher A. Ramsden ◽  
John A. Joule ◽  
Viktor V. Zhdankin
Keyword(s):  
Ring Systems ◽  
Ring Junction ◽  
Fused Ring

10.24.5 Product Subclass 5: Pyridazino[1,6-a]indoles and Related Benzo-Fused Ring Systems

2021 ◽  
Author(s):  
P. A. Harris
Keyword(s):  
Ring Systems ◽  
Fused Ring

AbstractThe synthesis of pyridazino[1,6-a]indoles, as well as the related indolo[1,2-b]cinnolines and indolo[2,1-a]phthalazines, are reviewed in this chapter. The most utilized methods to access pyridazino[1,6-a]indoles involve annulation of 1H-indol-1-amine derivatives.

10.24.4 Product Subclass 4: Pyrazino[1,2-a]indoles and Related Benzo-Fused Ring Systems

2021 ◽  
Author(s):  
P. A. Harris
Keyword(s):  
Indole Derivatives ◽  
Aryl Group ◽  
Ring Systems ◽  
Keto Ester ◽  
Fused Ring

AbstractThe synthesis of pyrazino[1,2-a]indoles and related indolo[1,2-a]quinoxalines and pyrido[2′,1′:3,4]pyrazino[1,2-a]indol-5-ium salts are reviewed in this chapter. The most common routes to pyrazino[1,2-a]indoles involve cyclization of indole derivatives containing a formyl, keto, ester, or nitrile function at the 2-position. Indolo[1,2-a]quinoxalines are most readily accessed via cyclization of 1-(aryl)-1H-indoles, where the aryl group is substituted at the 2-position by either amino, iodo, or nitro functionality.

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