One-Pot Preparation of Quinolizidin-2-one and Indolizidin-7-one Ring Systems. Concise Total Syntheses of (.+-.)-Myrtine, (.+-.)-Lasubine II, and (-)-Indolizidine 223AB

1995 ◽  
Vol 60 (3) ◽  
pp. 717-722 ◽  
Author(s):  
Ronaldo A. Pilli ◽  
Luiz Carlos Dias ◽  
Adriano O. Maldaner
Keyword(s):  
One Pot ◽  
Ring Systems ◽  
Total Syntheses ◽  
Indolizidine 223Ab

scholarly journals One-pot three-component synthesis of quinoxaline and phenazine ring systems using Fischer carbene complexes

2010 ◽  
Vol 6 ◽  
Author(s):  
Priyabrata Roy ◽  
Binay Krishna Ghorai
Keyword(s):  
Diels Alder ◽  
Fischer Carbene Complexes ◽  
One Pot ◽  
Carbene Complexes ◽  
Ring Systems ◽  
First Report ◽  
Fischer Carbene ◽  
Carbonyl Derivatives ◽  
Transient Intermediates ◽  
Three Component Coupling

One-pot three-component coupling ofo-alkynylheteroaryl carbonyl derivatives with Fischer carbene complexes and dienophiles leading to the synthesis of quinoxaline and phenazine ring systems has been investigated. This involves the generation of furo[3,4-b]pyrazine and furo[3,4-b]quinoxaline as transient intermediates, which were trapped with Diels–Alder dienophiles. This is the first report on furo[3,4-b]pyrazine intermediates.

Synthesis of Pyrazolofuropyrazine via One-Pot SNAr Reaction and Intramolecular Direct C–H Arylation

Synthesis ◽  
2018 ◽  
Vol 50 (07) ◽  
pp. 1493-1498 ◽  
Author(s):  
Shinichiro Fuse ◽  
Hiroyuki Nakamura ◽  
Megumi Inaba ◽  
Shinichi Sato ◽  
Manjusha Joshi
Keyword(s):  
Drug Discovery ◽  
Rapid Development ◽  
Ring System ◽  
Biologically Active ◽  
Drug Candidate ◽  
One Pot ◽  
Ring Systems ◽  
Drug Candidates ◽  
Fused Ring ◽  
Snar Reaction

Fused-ring systems containing heterocycles are attractive templates for drug discovery. Biologically active 6-5-5+6 fused-ring systems that possess heterocycles are available, but these require a relatively large number of synthetic steps for preparation. Therefore, pyrazolofuropyrazine was designed as a 6-5-5+6 ring system template that incorporates ready accessibility for drug discovery. Pyrazolofuropyrazines were successfully constructed in only a few steps via one-pot SNAr reaction/intramolecular C–H direct arylation. As a drug candidate, pyrazolofuropyrazine has earned a favorable LogP, although significant biological activity has yet to be established; the ready accessibility of pyrazolofuropyrazine template, however, offers an opportunity for the rapid development of promising new drug candidates.

Novel One-Pot Total Syntheses of Deoxyvasicinone, Mackinazolinone, Isaindigotone, and Their Derivatives Promoted by Microwave Irradiation

2005 ◽  
Vol 7 (15) ◽  
pp. 3363-3366 ◽  
Author(s):  
Ji-Feng Liu ◽  
Ping Ye ◽  
Kevin Sprague ◽  
Katie Sargent ◽  
Daniel Yohannes ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
One Pot ◽  
Total Syntheses
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