A Directed Metalation Route to the Selenium Analog of Methimazole

1994 ◽  
Vol 59 (16) ◽  
pp. 4691-4692 ◽  
Author(s):  
Lynn James Guziec ◽  
Frank S. Jr. Guziec
Keyword(s):  
Selenium Analog

Synthesis of isosteric selenium analog of the PPARβ/δ agonist GW501516 and comparison of biological activity

2010 ◽  
Vol 20 (14) ◽  
pp. 4050-4052 ◽  
Author(s):  
Arun K. Sharma ◽  
Ugir Hossain Sk ◽  
Pengfei He ◽  
Jeffrey M. Peters ◽  
Shantu Amin
Keyword(s):  
Biological Activity ◽  
Selenium Analog

Synthesis and Characterization of the Selenium Analog of Glutathione Disulfide

1993 ◽  
Vol 208 (1) ◽  
pp. 151-154 ◽  
Author(s):  
T. Tamura ◽  
T. Oikawa ◽  
A. Ohtaka ◽  
N. Fujii ◽  
N. Esaki ◽  
...  
Keyword(s):  
Synthesis And Characterization ◽  
Glutathione Disulfide ◽  
Selenium Analog

Moessbauer parameters of putidaredoxin and its selenium analog

Biochemistry ◽  
1972 ◽  
Vol 11 (5) ◽  
pp. 855-863 ◽  
Author(s):  
E. Muenck ◽  
P. G. Debrunner ◽  
J. C. M. Tsibris ◽  
I. C. Gunsalus
Keyword(s):  
Selenium Analog

scholarly journals In the Search for New Anticancer Drugs, IV+ Antitumor Activity of Seleno-TEPA

1983 ◽  
Vol 38 (9) ◽  
pp. 1138-1141 ◽  
Author(s):  
Maria Konieczny ◽  
Peter L. Gutierrez ◽  
George Sosnovsky
Keyword(s):  
Antitumor Activity ◽  
Anticancer Activity ◽  
Anticancer Drugs ◽  
Human Cell ◽  
Human Cell Lines ◽  
Colony Assay ◽  
Selenium Analog ◽  
New Anticancer Drugs ◽  
Cell Colony

Abstract In order to test the effect of selenium on the anticancer activity of alkylating drugs, Seleno-TEPA (4), the selenium analog of the clinically used Thio-TEPA (1) was tested in vivo against the lymphocytic P 388 and lymphoid L1210 murine leukemias. Compound 4 is more active against P 388 leukemia than against L1210, and appears to be active over a narrower concentration range than Thio-TEPA (1). Compound 4 is less active against P 388 leukemia than 1, as evidenced by the T/C values of 164 for 4 and 239 for 1 at a dose of 4.2 mg/kg. The activity of 4 was also evaluated on the HL60 and K 562 human cell lines. Under the conditions of the cell colony assay technique, Seleno-TEPA (4) is less effective than Thio-TEPA (1).

Quantum chemical study of the interaction between selenium analog of methimazole as an anti-thyroid drug and metal cations

2014 ◽  
Vol 25 (6) ◽  
pp. 1635-1645 ◽  
Author(s):  
Hossein Roohi ◽  
Mahjoubeh Jahantab ◽  
Parya Fakour ◽  
Minoo Rouhi
Keyword(s):  
Quantum Chemical ◽  
Quantum Chemical Study ◽  
Metal Cations ◽  
Chemical Study ◽  
Selenium Analog

scholarly journals Electrochemical Studies of Putidaredoxin and Its Selenium Analog

1973 ◽  
Vol 248 (17) ◽  
pp. 6059-6061
Author(s):  
George S. Wilson ◽  
John C.M. Tsibris ◽  
Irwin C. Gunsalus
Keyword(s):  
Electrochemical Studies ◽  
Selenium Analog

ChemInform Abstract: SYNTHESIS OF A SELENIUM ANALOG OF SEROTONIN

1976 ◽  
Vol 7 (43) ◽  
pp. no-no
Author(s):  
L. LAITEM ◽  
P. THIBAUT ◽  
L. CHRISTIAENS
Keyword(s):  
Selenium Analog
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