A Practical Synthesis of a COX-2-Specific Inhibitor

2000 ◽  
Vol 65 (25) ◽  
pp. 8415-8420 ◽  
Author(s):  
Ian W. Davies ◽  
Jean-Francois Marcoux ◽  
Edward G. Corley ◽  
Michel Journet ◽  
Dong-Wei Cai ◽  
...  
Keyword(s):  
Specific Inhibitor ◽  
Practical Synthesis ◽  
Cox 2

ChemInform Abstract: A Practical Synthesis of a COX-2-Specific Inhibitor.

ChemInform ◽  
2001 ◽  
Vol 32 (15) ◽  
pp. no-no
Author(s):  
Ian W. Davies ◽  
et al. et al.
Keyword(s):  
Specific Inhibitor ◽  
Practical Synthesis ◽  
Cox 2

COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat

2003 ◽  
Vol 284 (2) ◽  
pp. R574-R585 ◽  
Author(s):  
V. Y. Hu ◽  
S. Malley ◽  
A. Dattilio ◽  
J. B. Folsom ◽  
P. Zvara ◽  
...  
Keyword(s):  
Lower Urinary Tract ◽  
Specific Inhibitor ◽  
Female Rats ◽  
Prostaglandin E ◽  
Lower Urinary Tract Function ◽  
Tract Function ◽  
Cox 2 ◽  
Micturition Reflexes ◽  
Lower Urinary

The purpose of this study was to determine the role of cyclooxygenase-2 (COX-2) and its metabolites in lower urinary tract function after induction of acute (4 h), intermediate (48 h), or chronic (10 day) cyclophosphamide (CYP)-induced cystitis. Bladders were harvested from euthanized female rats for analyses. Conscious cystometry was used to assess the effects of a COX-2-specific inhibitor, 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl2(5 H)-furanone (DFU, 5 mg/kg sc), a disubstituted furanone, in CYP-induced cystitis. COX-2 mRNA was increased in inflamed bladders after acute (12-fold) and chronic (9-fold) treatment. COX-2 protein expression in inflamed bladders paralleled COX-2 mRNA expression. Prostaglandin D2-methoxime expression in the bladder was significantly ( P ≤ 0.01) increased in acute (3-fold) and chronic (5.5-fold) cystitis. Prostaglandin E2 was significantly ( P ≤ 0.01) increased (2-fold) in the bladder with intermediate (1.7-fold) and chronic (2.6-fold) cystitis. COX-2-immunoreactive cell profiles were distributed throughout the inflamed bladder and coexpressed histamine immunoreactivity. Conscious cystometry in rats treated with CYP + DFU showed increased micturition intervals 4 and 48 h after CYP treatment and decreased intravesical pressures during filling and micturition compared with rats treated with CYP + vehicle. These studies suggest an involvement of urinary bladder COX-2 and its metabolites in altered micturition reflexes with CYP-induced cystitis.

The COX-2 Specific Inhibitor Valdecoxib versus Tramadol in Acute Ankle Sprain

2006 ◽  
Vol 34 (6) ◽  
pp. 945-955 ◽  
Author(s):  
Evan F. Ekman ◽  
Gary Ruoff ◽  
Kerry Kuehl ◽  
Lee Ralph ◽  
Philip Hormbrey ◽  
...  
Keyword(s):  
Ankle Sprain ◽  
Specific Inhibitor ◽  
Cox 2

Determinants of cycloxygenase (COX)-2 specific inhibitor utilization in a managed care population

2000 ◽  
Vol 95 (9) ◽  
pp. 2637-2638
Author(s):  
D.V. Pettitt ◽  
G. Singh ◽  
J.S. Schwartz ◽  
J.L. Goldstein
Keyword(s):  
Managed Care ◽  
Specific Inhibitor ◽  
Cox 2

COX-2 specific inhibitor reduces pancreatic cancer cell invasion through alteration of cellular adhesion and MMP activation

2001 ◽  
Vol 120 (5) ◽  
pp. A616
Author(s):  
Jiro Okami ◽  
Shoji Nakamori ◽  
Masato Sakon ◽  
Hirofumi Yamamoto ◽  
Nobuaki Hiraok ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Pancreatic Cancer Cell ◽  
Specific Inhibitor ◽  
Cellular Adhesion ◽  
Cancer Cell Invasion ◽  
Cox 2

Room H, 10/16/2000 9: 00 AM - 11: 00 AM (PS) Effects of Parecoxib, a Parenteral COX-2 Specific Inhibitor, on the Disposition of Midazolam 

2000 ◽  
Vol 93 (3A) ◽  
pp. A-529
Author(s):  
Andra Ibrahim ◽  
Aziz Karim ◽  
Jennifer Feldman ◽  
Evan Kharasch
Keyword(s):  
Specific Inhibitor ◽  
Cox 2

Impairment of breast cancer cell invasion by COX-2-specific inhibitor NS398: roles of CXCR4 and of uPA system

2011 ◽  
Vol 29 (3) ◽  
pp. 1468-1476 ◽  
Author(s):  
Henriqueta Coimbra Silva ◽  
Vera Alves ◽  
Luis Alcides Mesquita Nogueira ◽  
Manuel Santos Rosa ◽  
Lina Carvalho ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Invasion ◽  
Specific Inhibitor ◽  
Cancer Cell Invasion ◽  
Breast Cancer Cell Invasion ◽  
Upa System ◽  
Cox 2
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