Building units for N-backbone cyclic peptides. 1. Synthesis of protected N-(.omega.-aminoalkylene)amino acids and their incorporation into dipeptide units

1992 ◽  
Vol 57 (21) ◽  
pp. 5687-5692 ◽  
Author(s):  
Gerardo Byk ◽  
Chaim Gilon
Keyword(s):  
Amino Acids ◽  
Cyclic Peptides ◽  
Backbone Cyclic Peptides

Conformational Analysis of SomeC2-Symmetric Cyclic Peptides Containing Tetrahydrofuran Amino Acids†

2006 ◽  
Vol 71 (16) ◽  
pp. 6240-6243 ◽  
Author(s):  
Tushar Kanti Chakraborty ◽  
Saumya Roy ◽  
Dipankar Koley ◽  
Samit Kumar Dutta ◽  
Ajit Chand Kunwar
Keyword(s):  
Amino Acids ◽  
Conformational Analysis ◽  
Cyclic Peptides

Peptide Cyclization at High Concentration

Synlett ◽  
2020 ◽  
Vol 31 (16) ◽  
pp. 1537-1542
Author(s):  
Monika Raj ◽  
Rachel D. Wills ◽  
Victor T. Adebomi
Keyword(s):  
Amino Acids ◽  
Cyclic Peptides ◽  
High Concentration ◽  
Peptide Cyclization ◽  
Synthetic Strategy ◽  
New Methodologies ◽  
High Concentrations

The emergence of cyclic peptides as pharmaceuticals has led to an eruption of new methodologies for macrocyclization. However, the cyclization of peptides at high concentrations presents a challenge due to the production of side products like dimers and oligomers. This factor is more pronounced with the cyclization of peptides composed of fewer than seven amino acids, thus has created a need for a new synthetic strategy. Herein, we will elucidate a new chemoselective method termed ‘CyClick’ that works in an exclusively intramolecular fashion preventing the formation of commonly occurring side products such as dimers and oligomers, even at relatively high concentration.1 Introduction2 Known Methodologies3 Novel CyClick Chemistry4 Conclusion and Outlook

Molecular Design and Synthesis of Artificial Ion Channels Based on Cyclic Peptides Containing Unnatural Amino Acids

2001 ◽  
Vol 66 (9) ◽  
pp. 2978-2989 ◽  
Author(s):  
Hitoshi Ishida ◽  
Zhi Qi ◽  
Masahiro Sokabe ◽  
Kiyoshi Donowaki ◽  
Yoshihisa Inoue
Keyword(s):  
Amino Acids ◽  
Ion Channels ◽  
Unnatural Amino Acids ◽  
Cyclic Peptides ◽  
Molecular Design ◽  
Design And Synthesis
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